USTNotesGroup2010 Myelinated Nerve Fiber in

Slides done by A. Abad Long Section (Teased Fiber)

Pictures from A. Abad, M. Castro, and R. Go
Myelinated nerve with node
of ranvier

HE stain XS Muscle fibers

-note polygonal appearance
(architecture)
– subsarcolemal
nucleus/nuclei XS of Nerve Fasicles
- pointer at perimysial blood Perineurium pointer
vessel
PNS Vasa Nervorum

LS of Nerve Fascicle Perinuerium with Vasa Neurvorum

(pointer)

XS of several Nerve Fascicles

Epineurium (pointer)
PNS Vasa Nervorum

Neural Tube, Notochord, and

Somites
Somites (pointer), which are
condensations composed of
mesoderm, appear on either
LS of Nerve Fascicle Neurilemma (sheath of Schwann) with side of the neural groove.
endonuerium (pointer) The first pair of somites
appear at the tail and
progress to the middle.
Somites (pointer) differentiate
into dermomyotome (dermal
and muscle component) and
sclerotome (forms vertebral
column). MESODERM
If twenty somites are present in
the embryo, the forebrain is
completely closed.
XS of Myelinated Nerve Fibers Twenty-one to Twenty-nine
Axis cylinder (pointer) Somite Pairs, Caudal Neuropore
Closes,

Neural Tube (pointer) with

Notochord below
ECTODERM
Neural Tube forms primary brain
vesicles:
a)prosencephalon: forebrain
b)mesencephalon: midbrain
c)rhombencephalon: hindbrain & SC
LS of Nerve Fascicle Node of Neural Tube gives rise to CNS,
Ranvier @ pointer Rostral 2/3 brain and Caudal 1/3
Spinal cord
Neural Tube and Notochord
(pointer) [ECTODERM]
Notochord source of cell
adhesion molecules for
neural plate
 Telencephalia Vesicle WHITE MATTER
(pointer) from Prosancephalon - regions where fiber
tracts travel
Prosancephalon (Forebrain) - fiber tracts: enclosed
in myelin sheath,
Telencephalan Cerebral where white color is
Hemisphere Lateral attributed
Ventricles - Oligodendrocyte:
forms the myelin
sheath in the CNS
- Schwann Cell:
myelinate nerve cells
in the PNS
GRAY MATTER
- mainly nuclear areas
and forms the
cerebral cortex
- Reticular formation:
scattered aggregates
of gray matter
arranged in a netlike
fashion interspersed
among threads of
white matter

Anterior Neuropore 31 Pairs of Spinal Nerves 33 Vertebrae

(pointer) Cervical 8 Cervical 7
Thoracic 12 Thoracic 12
Closes at Day 24, failure Lumbar 5 Lumbar 5
to close leads to Sacral 5 Sacral 5 (fused)
anencephaly Coccygeal 1 Coccygeal 4
(lower 3 fused)

PERIPHERAL NERVE FIBER CLASSIFICATION 1

Muscle Cutaneous Fiber Axon Velocity Efferent nerve Afferent cutaneous Afferent muscle
nerve nerve type* diameter (m/s) (motor) nerve nerve
(um)
I Aα M 12-20 72-120 1a
α Motor neurons - (muscle spindle,
to skeletal nuclear bag &
muscle nuclear chain)
1b (GTO)
- Mechanoreceptors Nuclear chain
II Aβ M 6-12 36-72
Fiber
γ Motor neurons Thermoreceptors -
III Aδ, Aγ M 1-6 4-36 to intrafusal Nociceptors
fibers
- Thermoreceptors -
IV C Unm 0.2 – 1.5 0.4-2.0
Nociceptors
*M = myelinated, Unm = unmyelinated
1
modified from Dr. King’s handout on Somatosensory system and Kandel’s Principle of Neuroscience, 4th ed
• Roman numerals are also used in classifying nerves according to diameter
• Alphabets are also used to classify nerves according to velocity

- fin -

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