Pharmacoeconomics and Health Outcomes

Group Exercise Cover Sheet

Honor Code
Last Name, First Name (PRINTED!) Signature
(i.e. “Submitted with honor”)

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 Quality of Life Study Analysis
These questions are generated from the study by Singh et. al. which utilized several quality of
life of life instruments (surveys) during their study of atrial fibrillation patients.
NOTE: Please write ALL your final answers in this table, it will be easier to grade. Thanks!

Question
Circle answers here:
Number:

1. A. B. C. D. E.

2. A. B. C. D. E.

3. A. B. C. D. E.

4. A. B. C. D. E.

5. A. B. C. D. E.

6. A. B. C. D. E.
01. All of the following disease-specific QOL instruments were used in this study, except for
the: ___________________________
A. Atrial Fibrillation Severity Scale (AFSS)
B. SF-36
C. Specific Activity Scale (SAS)
D. Arrhythmia-related Symptom Checklist (SCL)
E. All of the above disease-specific instruments were used

02. The authors used which statistical methods to demonstrate clinical significance?
A. analysis of covariance
B. 2-sample t test
C. paired t test
D. effect size
E. More than one of the above is correct

03. Comparing SR patients to AF patients from baseline to 1 year described in Table 3, the
authors found the following statistically significant QOL results:
A. improvement on all 8 subscales of the SF-36
B. worsening on the SCL scores
C. improvement on the SAS scores
D. improvement on AF symptom score
E. more than one of the above is correct

04. The authors compared changes in the SF-36 scores to changes in exercise performance
(EP). This is a great example of which type of validation:
A. factorial validity
B. construct validity
C. criterion validity
D. content validity
E. more than one of the above is correct

05. The correlation between exercise performance (i.e. exercise treadmill test (ETT) duration)
and SF-36 scores was strongest between:
A. SF-36 scores on the emotional role limitations in the AF group at 1 year
B. SF-36 scores on the social function domain in the SR group at 1 year
C. SF-36 scores on the physical functioning domain in the SR group at 1 year
D. SF-36 scores on the general health domain in the SR group at 8 weeks
E. None of the above are correct

06. Which of the following could be considered limitations (or at least cautions) for
interpreting the results of this study.
A. the study received funding from the manufacturers of amiodarone
B. the study received funding from the manufacturers of sotalol
C. patients were not randomly assigned into the SR or the AF groups
D. fewer AF patients completed the exercise performance tests
E. more than one of the above is correct.