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Name of Drug Dosage/Preparation Atropine Sulfate

Classification/Indication

Classification:
Anticholinergic Antimuscarinic Parasympatholytic Antiparkinsonian Antidote

Contraindication/Adverse Reactions Contraindication: Any previous known adverse reaction, tachycardia (racing heart beat), certain forms of heart disease, glaucoma, pyloric stenosis and any other condition that affects the movement of material through the digestive tract. Atropine should not be given to pregnant women or nursing mothers if at all possible. It can be secreted in the milk leading to a child taking in a toxic dose. There is a general lack of information on its effects on the fetus and the newborn. Adverse Reaction: Adverse reactions and side effects are relatively common when therapeutic doses are used although they are

Drug to Drug Interaction Drug to Drug: Interacts with other drugs acting on the same target (anticholinergics), can also interact with -cholinergics, - digitalis, - neostigmine, -antipsychotics, -antihistamines, -antidepressants including benzodiazepines, procainamide and quinidine.

Nursing Responsibilities Monitor vital signs. HR is a sensitive indicator of patient's response to atropine. Be alert to changes in quality, rate, and rhythm of HR and respiration and to changes in BP and Temperature. Initial Paradoxical bradycardia following IV atropine usually lasts only 12 min; it most likely occurs when IV is administered slowly (more than 1 min) or when small doses (less than 0.5 mg) are used. Postural hypotension occurs when patient ambulates too soon after parenteral administration . Note: Frequent and continued use of eye preparations, as well as overdosage, can have systemic effects. Some atropine deaths have

Dosage: Adult: Preanesthesia: IV/IM/SC 0.21 mg 3060 min before surgery Arrhythmias: IV/IM 0.51 mg q12h prn (max: 2 mg) Organophosphate Antidote: IV/IM 12 mg q5 60min until muscarinic signs and symptoms subside (may

Indication: When symptoms of nerve agent poisoning (miosis, salivation, spasm) are seen. Dosage depends upon the degree of exposure and the patient needs to be titrated (given increased doses until a therapeutic effect is seen.)

need up to 50mg) COPD: Inhalation 0.025 mg/kg diluted with 35 mL saline, via nebulizer 34 times daily (max: 2.5 mg/d) Uveitis Ophthalmic: 12 drops of solution or small amount of ointment in eye up to t.i.d.

generally short lived. They include: - dry mouth - blurred vision -photophobia -tachycardia. Patients may also stop sweating making them prone to discomfort in warm weather. Excessive doses can lead to excessive thirst, dizziness, tremor fatigue and loss of coordination.

resulted from systemic absorption following ocular administration in infants and children. Monitor I&O, especially in older adults and patients who have had surgery (drug may contribute to urinary retention).Palpate lower abdomen for distention. Have patient void before giving atropine.

Preparation: Injection