Jordan University of Science and Technology Faculty of Pharmacy Department of Pharmaceutical Technology Semester 1 Year 2008/2009 Course Syllabus

s Course Information
Course Title Course Code Prerequisites Course Website Instructor Office Location Office Phone # Office Hours E-mail Teaching Assistant(s) Pharmaceutics 1 Phar 351 Pharmaceutical Organic Chemistry 2 (Phar 222) NA Dr. Shadi Gharaibeh, Dr. Suhair Al-Nimry P2 L1 Dr. Gharaibeh: ext. 23442, Dr. Al-Nimry: ext. 23435 TBA Dr. Shadi Gharaibeh: shadi_gharaibeh@hotmail.com Dr. Suhair Al-Nimry: suhairnimry@just.edu.jo NA

Course Description
This course integrates the principles of physical pharmacy and traditional and modern pharmaceutical dosage forms. Covered topics are oral solutions, otic, nasal and ophthalmic preparations, and sterile pharmaceutical dosage forms.

Textbook
Title 1: Editor(s) Publisher Year Edition Book Website Title Editor(s) Publisher Edition Year Book Website Other references
1. Martins Physical Pharmacy and Pharmaceutical Sciences Patrick J. Sinko Lippincott Williams & Wilkins 2006 5th Edition 2. Pharmaceutical Dosage Forms and Drug Delivery Systems Loyd V. Allen, Jr., Nicolas G. Popovich & Howard C. Ansel Lippincott Williams & Wilkins 8th Edition 2005 Pharmaceutics The Science of Dosage Form Design, Edit.: Michael E. Aulton, Pub.: Churchill Livingstone, 2nd edition, 2002.

Assessment
Assessment First Exam Second Exam Final Exam Assignments Participation Attendance Expected Due Date
Sunday 26/10/2008 @ 4:15 5:15 in 10 H1, 10 H2, 10 H3, 10 H4, N2 (nursing lab) Sunday 30/11/2008 @ 4:15 5:15 in 10 H1, 10 H2, 10 H3, 10 H4, N2 (nursing lab) Starts on 13/1/2008 ends on 21/1/2009 -

Percentage
30% 30% 40% -

Course Objectives 1.
2. 3. 4. To develop knowledge of the fundamental physicochemical properties of drugs and asses their role and applications in solution dosage forms. To understand the theory and applications of the phenomenon of solubility. To be able to carry out calculations that are vital in pharmacy such as: pH, solubility, concentration, .etc. To build a background in understanding the fundamentals of formulation and applications of different solution dosage forms available in the pharmacy practice. To understand the basics of ophthalmic and parenteral formulations and their

Percentage
15% 25% 10% 30% 20%

5.

pharmaceutical applications.

Teaching & Learning Methods

1. Class lectures and lecture notes are designed to achieve the course objectives. 2. Students should read the assigned chapters before class, participate in class and do whatever it takes for you to grasp this material. Ask questions; ask lots of questions. 3. Students are responsible for all material covered in the class. 4. Please communicate any concerns or issues either in class or at the instructors office hours.

Learning Outcomes: Upon successful completion of this course, students will be able to Related Objective(s) Out comes Reference(s) Choose the best solvent medium for a drug or 1, 2 10
combination of drugs. Overcome the difficulties that arise in the preparation of pharmaceutical solutions. solution, parentral products and fluids applied to abraded surfaces. in preparation of solution dosage forms.

3 4, 5

Minimize tissue irritation when formulating ophthalmic Be familiar with the principles and technologies applied Be familiar with the regulations governing the Useful Resources
manufacturing and compounding of pharmaceuticals.

9 13

Books, selected hand outs and announced websites. Website: www.just.edu.jo/~sfg/pharmacy.htm

Week 12 1. Topics Solutions of non-electrolytes Ideal and real solutions Henrys law Solutions of electrolytes Theory of strong electrolytes Ionic equilibria: pH of solutions Chapter 5 Textbook (handouts) 1

23 45

2.

6 7

1 1

3.

67

8 10

11 12

Modern theory of acids, bases, and salts Acid-base equilibrium Sorensens pH scale Calculation of pH Acidity constants 4. Buffered and isotonic solutions The buffer equation Buffer capacity Buffers in pharmaceutical and biological systems Buffered isotonic solutions Methods of adjusting tonicity and pH 5. Solubility and distribution phenomena General principles Solvent-solute interaction Solubility of gases in liquids Solubility of liquids in liquids Solubility of solids in liquids Distribution of solutes between miscible solvents 6. Pharmaceutical solutions Introduction Solvents and vehicles Preparation of solutions Formulation considerations Oral solutions Syrups Elixirs Tinctures

10

13

13

7.

Other types of solution preparations Nasal solutions

13, 17

14

15 17

Otic solutions Topical solutions Vaginal & Rectal 8. Ophthalmic preparations Pharmaceutical requirements Packaging ophthalmics Proper administration Contact lens and care and use solutions 9. Parenteral preparations Parenteral routes Types of injections Solvents and vehicles Non-aqueous vehicles Additives Methods of sterilisation Small volume parenterals Large volume parenterals Special considerations & other injectable products

17

15

Additional Notes
Exams Exams are generally online. The format for the exams is generally multiple-choice questions (MCQS). Grades will not be given out via e-mail. Makeup exam should not be given unless there is a valid excuse. Arrangements to take an exam at a time different than the one scheduled MUST be made prior to the scheduled exam time. Last day to drop the course is before the twelve (12th) week of the current semester, on the th 6 of December 2008. The commitment of the acts of cheating and deceit such as copying during examinations, altering examinations for re-grade, plagiarism of homework assignments, and in any way representing the work of others as your own is dishonest and will not be tolerated. Standard JUST policy will be applied : 7: .- .- .- Excellent attendance is expected. JUST policy requires the faculty member to assign ZERO grade (35) if a student misses 10% of the classes that are not excused. If you miss class, it is your responsibility to find out about any announcements or assignments you may have missed. Average work-load student should expect to spend is 6 hours/week. Each student shall check his answer sheet with the KEY.

Makeup Exams Drop Date Cheating

Attendance

Workload Graded Exams