BioIsoprene Monomer: Development of a Bio-based Process for Production of Isoprene from Renewable Resources

Richard J. LaDuca Genencor/Danisco March 15, 2010 World Biofuels Markets

Amsterdam

Purpose for Today:

Bio-product Target: Isoprene / BioIsoprene Monomer

What makes BioIsoprene Monomer a good target?

Collaborative approach to development Building a BUSINESS PLATFORM Biochemicals Biofuels
H C H2C
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CH3 C CH2
Isoprene
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Genencor at a Glance.

We develop and produce enzymes for industrial applications.

History traced to 1982 May 2005: Division of Danisco Industrial Biotechnology Focus > $800 MM USD annual turnover Core Competency: Design & Operation of the Cell Factory Industrial Enzymes Metabolic Pathway Engineering
1,3 Propanediol

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Ascorbic Acid

Building Block Biochemicals:

Add Isoprene to the list of building block biochemicals.

Why go after Isoprene?

TREES

PETROLEUM CRACKING

CHEMICAL SYNTHESIS

BIOBASED PROCESS

Slow Not commercially relevant

Extractive distillation from Ethylene & Propylene production Price linked to oil prices Moving to light streams

High cost Petroleum feedstocks Mfg. infrastructure in Russia & Japan

Renewable feedstocks GHG reduction Low Cost Biochemical AND Biofuel Products
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Why go after Isoprene?

Big Market: (~800 kt; 2008 volume basis) Tires (450-500 kt) Adhesives (150 kt) Medical / Personal Care (40-50 kt) Strategic Raw Material: Synthetic Rubber Natural Rubber Replacement

Isoprene Market Segmentation

Tires 62%

Current Commercial Processes: Mechanical Goods Petroleum-based feedstocks 4% Cost linked to oil Availability of supply has been an issue
BioIsoprene Process: Renewable raw materials Polymer-Grade Sustainable Low Cost

Other 9%

Medical / Personal Care 6%

Adhesives 19%

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Genencor and Goodyear will jointly develop BioIsoprene Process

A collaborative research initiative

Joint multimillion-dollar investment

BioIsoprene product is a biobased, renewable alternative to the petroleum-based isoprene BioIsoprene product is a business platform chemical Genencor will lead commercial development

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Genencor and Goodyear leveraging each others expertise

H C H2C C

CH3

CH2

Renewable Feedstock(s)

Microbial Strain Development

Large Scale Fermentation

BioIsoprene recovery & purification knowhow

Polymer-Grade BioIsoprene Product

Integrated biobased process for production of BioIsoprene

Material Challenges: Tire Industry

Renewable/Sustainable Feedstocks Develop alternative to Natural Rubber Eliminate dependence on petrochemical waste streams for isoprene feedstocks Reduce need for Carbon Black Reduce material & energy waste from spent tires Recyclability Improve performance while reducing weight: traction, wear, fuel economy, noise, etc.

Carbon Black & Silica 27%

Synthetic & Natural Rubber 43%

Steel 10%

Fabric 5%

Chemicals 10%

Oil 5%

Over 70% of raw materials are petroleum derived

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Value of BioIsoprene Product:

To Goodyear:
Strategic Raw Material for Synthetic Polyisoprene Rubber Cost Sustainability Decrease dependence on natural rubber sourcing

To Genencor:
Builds off of core competencies Consistent with Strategic Intent to grow new businesses Builds off of know-how and past successes

Aligns complementary skills, investment, strategic intent and market connectivity

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BioIsoprene Product will Enable:

Alternative supply of a key strategic raw material for synthetic rubber Decreased dependence on natural rubber sourcing Reduced petroleum price impact on isoprene costs Supply of isoprene de-linked from petroleum processing Isoprene cost savings Movement to a more sustainable isoprene production method Enhanced availability of supply
Adhesives Specialty Polymers Synthetic Rubber

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A Bio-based process for ISOPRENE from renewable raw materials

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BioIsoprene Process:

rDNA Process Renewable raw material feedstocks Metabolic Pathway engineering of isoprenoid pathways Isoprene product produced in gas phase Polymer grade product
Renewable Feedstocks

Polymer Grade BioIsoprene Product

Gas-phase BioIsoprene product recovered & purified to liquidphase

Integrated bio/chemical process

Details: Tuesday March 16th; Dr. Karl Sanford; Next Generation Biofuels Session
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BioIsoprene C5 Biorefinery: Business Platform

Biochemicals Business: Tires Adhesives Specialty Polymers

H C H2C C

CH3

CH2

Renewable Feedstock(s)

Microbial Strain Development

Large Scale Fermentation

BioIsoprene recovery & purification knowhow

BioIsoprene Product

+ Fuel Partner
+ C10 Isomers + C15 Isomers

Chemical Catalysis

BioIsoFuels Transportation / Jet Fuels Business

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BioIsoprene Product Enables Biorefinery Approach:

BioIsoprene process, developed jointly by Genencor and The Goodyear Tire & Rubber Company BioIsoprene Production: rDNA Biomass-based Gas Phase Product Establishes C5 Platform (5-carbon molecule) to produce valuable products: A Business Platform Chemical Biochemicals: Tires; Adhesives; Specialty Elastomers Biofuels: Liquid transportation Fuels; Jet Fuels
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Concept BioIsopreneTM Tire for the UN Climate Summit, Dec 2009, CPH