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Erythrocytes
• Manufacture hemoglobin until it accounts for some 90% of the dry weight of the
cell.
• Nucleus, ribosomes and mitochondria are lost in the process of maturation of
erythrocyte. Fig. 22-37
• The most numerous type in the blood.
Neutrophil:
Phagocytose and destroy microorganisms. Granules - lysosomes
Eosinophil:
Destroy parasites by releasing cytotoxic granules content, modulate
allergic inflammatory response
Basophil:
Mediate inflamatory response. Granules -secretory vesicles, contain histamine,
Leucocytes
• Granulocytes
o neutrophils,
o basophils,
o eosinophils
• Monocytes
Once they leave the bloodstream, mature in:
o Macrophages (large cell, that engulf dead and damaged cells, large
microorganisms)
o dendritic cells - immune response
• Lymphocytes - immune response
o B-lymphocytes (Bone marrow)
o T-lymphocytes (Thymus)
o Natural killer cells
Growth of muscles
Fibroblasts
• The least specialized cells in connective tissue family Dispersed throughout the
body
• Secrete extracellular matrix, that is rich in collagen
• Help to repair damaged tissue
They proliferate, migrate into the wound and produce large amounts of collagen matrix
• Can differentiate (“mature”) into other connective tissue cells
They can occur in more or less “mature” state throughout the body. The most immature
are called mesenchymal stem cells mostly found in bone marrow (mesenchyme =
mesoderm)
• Can grow in culture
Osteoblasts lie on bone surface just below the precursors, secrete osteoid, the uncalcified,
organic matrix of bone. As osteoblasts differentiate into osteocytes, the osteoid is rapidly
calcifed and the osteocytes get embedded in this matrix.
Giant, multinulcleated, erodes bone matrix. Ruffled border is site of secretion of acids to
dissolve bone minerals and hydrolases to digest the organic components of the matrix.
Can send out processes to resorb bone a multiple sites. Are specialized macrophages
developed from monocytes.
Osteoclasts excavate bone at 50um per day. Capillary endothelial cells and osteoblasts
follow, latter fill tunnel with new bone. In mammals, 10-15% of bone is replaced per
year.
Long bones in the limb develop from cartilage models formed during fetal development.
The cartilage is believed to be eroded by osteoclasts to make way for bone. As cartilage
matures, chondrocyte in central areas enlarge, the matrix around them becomes
mineralized and the swollen chondrocytes die leaving large cavities. These are invaded
by osteoclasts & blood vessels, remove residual cartilage matrix. Osteoblasts enter in
their wake and begin to deposit bone. The only surviving cartilage is a the ends of the
bones, for joint articulation
Practice questions
1. Osteoporosis: low bone density, due to excessive bone erosion (osteoclast
activity>osteoblast activity)
2. Osteopetrosis: abnormally high bone density (osteoblast activity>osteoclast
activity)
3. What tissues come from mesoderm?
4. What are the main kinds of cells in blood?
5. What is the main function of leucocytes?
6. What is the most numerous kind of cells in blood?
7. Which of the blood cells have no nucleus?
8. What are the three types of leucocytes?
9. Which type of granulocytes is able to engulf microorganisms?
10. Which type of granulocytes can secrete histamine?
11. What is the tissue where megakaryocytes can be found?
12. Which cells come from myeloid cell line?
13. Can number of muscle fibers change in adulthood?
14. What are connective tissue cells?
15. Which cells can fibroblasts turn into?
16. What is name of the cell responsible for old bone destruction?
17. What is the cause of osteoporosis?
18. What kind of cell is adipocyte?
19. Which tissue would you select to obtain mesenchymal stem cells?
Terms to know:
Erythrocytes
Leucocytes
Plateletes (thrombocytes)
Granulocytes
neutrophils
basophils
eosinophils
Monocytes
megakaryocytes
hemopoiesis
lymphoid cell line
myeloid cell line
stromal cells
myoblasts
Fibroblasts,
Chrondrocyte (cartilage cells)
Adipocyte (fat cell)
Osteoclasts
Osteoblasts
Osteoporosis
Osteopetrosis