Clotrimazole - Wikipedia, bch khoa ton th mi n ph

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Clotrimazole
T Wikipedia, bch khoa ton th mi n ph

Clotrimazole

Tn h th ng ( IUPAC )
1 - [(2-chlorophenyl) (diphenyl) methyl] -1 H-imidazole

Lm sng d li u Tn thng Lotriminaf, Mycelex m i AHFS / chuyn kh o (http://translate.googleusercontent.com/translate_c?hl=vi& Drugs.com prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.drugs.com/monograph/clotrimazole.html& usg=ALkJrhhDZFpf7C3mBXoG0YQn9Sa16bnoGQ) MedlinePlus a682753 (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682753.html& usg=ALkJrhj0XlM932huin8LINZ0ir8vb9BLpA) Mang thai mo. a v php P ( Vng qu c Anh ) l Tuy n ng t i ch D c ng d li u
( AU C)

(u ng) & B (t i ch ) ( M )

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Clotrimazole - Wikipedia, bch khoa ton th mi n ph

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Kh d ng sinh h c

Km v th t th ng h p th b ng mi ng

Protein lin 90% k t S trao ch t Half-life 2 gi nh danh S CAS 23593-75-1 (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.nlm.nih.gov/cgi/mesh /2009/MB_cgi%3Fterm%3D23593-75-1%26rn%3D1&usg=ALkJrhhEsp2aNJOeP_YwTALFlqYAE2B3iA) ATC m A01 AB18 (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.whocc.no/atc_ddd_index/%3Fcode%3DA01AB18& usg=ALkJrhhjSwh67K7ZJmQ-cxHvbsnGOtLMTg) D01 AC01 (http://translate.googleusercontent.com /translate_c?hl=vi&prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.whocc.no/atc_ddd_index/%3Fcode%3DD01AC01& usg=ALkJrhjWKnOJPDecqf16HdGC1pS9rcCGSQ) G01 AF02 (http://translate.googleusercontent.com /translate_c?hl=vi&prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.whocc.no/atc_ddd_index/%3Fcode%3DG01AF02& usg=ALkJrhikmzDDjRTTv1J8XLoOuxRs6265EA) QJ02 AB90 (http://translate.googleusercontent.com /translate_c?hl=vi&prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.whocc.no/atcvet/atcvet_index/%3Fcode%3DQJ02AB90& usg=ALkJrhjZTMgWGWkU6YVjsJNl0L40eyV7BQ) PubChem CID 2812 (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://pubchem.ncbi.nlm.nih.gov/summary /summary.cgi%3Fcid%3D2812&usg=ALkJrhgGW6Y2fVSwn55FKf9EWq7j2-YU7Q) DrugBank APRD00244 (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.drugbank.ca/drugs/APRD00244& usg=ALkJrhhHxlDvlIVbenhm3M9lYG5PmVvvpg) ChemSpider 2710 (http://www.chemspider.com/Chemical-Structure.2710) UNII G07GZ97H65 (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://fdasis.nlm.nih.gov i gan

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/srs/srsdirect.jsp%3Fregno%3DG07GZ97H65&usg=ALkJrhh09sRTnzkewqvIxd6bjdOwA_3C6w) KEGG D00282 (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.kegg.jp/entry/D00282& usg=ALkJrhj4y7_12ehS1oqF1U6DzRdTSls55w) ChEBI ChEMBL CHEBI: 3764 (https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:3764) CHEMBL104 (https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL104) Ha ch t d li u Cng th c Mol. hng lo t SMILES eMolecules (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.emolecules.com/cgi-bin /search%3Ft%3Dex%26q%3DClc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4& usg=ALkJrhged7WKsNC9__nOA7CYmSGSz179Yw) & PubChem (http://translate.googleusercontent.com /translate_c?hl=vi&prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://pubchem.ncbi.nlm.nih.gov/search /%3Fsmarts%3DClc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4& usg=ALkJrhiVhQrHcHXLkG9AX4G0w48eFDvnBw) InChI (l nh ng g?) (xc minh) (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://en.wikipedia.org/w/index.php %3F%26diff%3Dcur%26oldid%3D443538132&usg=ALkJrhgTr5Z2rMA5eHF5X6XlHUOJm2RvwQ) C 22 H 17 Cl N 2 344,837 g / mol

Clotrimazole (Canesten tn thng hi u ho c Lotrimin) l m t thu c khng n m th ng c s d ng trong i u tr cc b nh nhi m trng n m (c a c hai ng i v ng v t khc) ch ng h n nh nhi m n m m o , b nh ta mi ng u ng, v binh ghe . N cng c s d ng i u tr bn chn c a v n ng vin v ng a jock .

N i dung
1 y t s d ng 2 Phng php c a hnh 3 Tng tc thu c 4 Side-hi u ng 5 s n xu t 6 tc ng mi tr ng 7 Ti li u tham kh o 8 Lin k t ngoi ng

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Y t s d ng
N th ng c s n nh l m t ch t-the-counter trong cc hnh th c li u l ng khc nhau , ch ng h n nh l kem, v cng c th ( c bi t l trong tr ng h p b nhi m trng tai) nh m t lo i thu c k t h p. N cng c s n nh l m t Troche (theo toa). i v i nhi m trng tai, n th ng c p d ng d ng l ng, nh gi m tai. Nhi m n m c th c lm ch m lm sng t , v v y qu trnh thng th ng cho m t tc nhn ch ng n m, ni chung, di hn 3-7 ngy i n hnh c a m t khng sinh . Clotrimazole l cng th ng c tm th y trong k t h p v i betamethasone, c bi t n nh Lotriderm, thm cc thu c tnh steroid . [1 ]

Phng php hnh

ng

Clotrimazole lm thay i tnh th m c a thnh t bo n m v c ch s ho t ng c a cc enzyme trong t bo. i u ny cu i cng d n n ci ch t c a t bo. N khng ng c lan truy n qua c th c a ng i s d ng nhng v n cn t i th i i m p d ng . [2 ]

Tng tc thu c
Ti m nng tng tc thu c v i clotrimazole u ng t n t i, v n l m t ch t c ch m nh, c th c a cytochrome P450 oxidase v c th lm thay i chuy n ha c a nh ng thu c khc .

Side tc
Tc d ng ph bao g m ban c a kch ng da. [ 3] da, pht ban, ph ng r p, rt, ng a, bong trc, , au nh c, sng, ho c d u hi u khc

S n xu t
H p ch t ny (3) c s n xu t b ng cch alkylating imidazol (1) v i o-chlorotrityl clorua (2) trong acetone, v i triethylamine c s . [4 ]

tc

ng mi tr ng

M t s nghin c u cho th y r ng, k t h p v i cc ch t ha h c khc th ng c s d ng, clotrimazole c tc d ng tiu c c i v i mi tr ng i dng, c bi t l vi t o. [5]

Ti li u tham kh o
1. 2. ^ "Clotrimazole" (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefox-

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a%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.fungalguide.ca/treatments/clotrimazole.html& usg=ALkJrhh8_pRXjNqQ56h99m2o8KSn5EgDqg) n m H ng d n. ca. Vancouver, BC Canada. http://www.fungalguide.ca /treatments/clotrimazole.html . L y 15 thng hai 2011. 3. ^ Canesten t i ch ng i tiu dng thng tin t (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.drugs.com/cons/canesten-topical.html& usg=ALkJrhiuIyjsfa4Nbm__Zo3K8GwpveykOg) Drugs.com 4. ^ OSPAR y ban: nguy hi m ch t Series: OSPAR n n ti li u trn clotrimazole OSPAR Xu t b n 2005/199, nm 2005, ISBN 1-904426-38-7 (pdf, Engl.) (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.ospar.org/documents/dbase/publications /p00199_BD%2520on%2520clotrimazole.pdf&usg=ALkJrhjdfUxbWQROQ8oG1KU9jWgf3vERpw) 5. ^ thu c c s d ng i u tr cc i u ki n da l m t ch t (http://translate.googleusercontent.com/translate_c?hl=vi& prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.eurekalert.org/pub_releases/2009-03/uog-dut032409.php& usg=ALkJrhhHiaWHpse0dSDqL7Cxk7OJR_meDA) gy nhi m bi n

Lin k t ngoi
Clotrimazole | MedlinePlus (http://translate.googleusercontent.com/translate_c?hl=vi&

Canesten (clotrimazole) kem ch ng n m

prev=/search%3Fq%3Dclotrimazole%253F%26hl%3Dvi%26client%3Dfirefoxa%26hs%3DRWL%26rls%3Dorg.mozilla:vi:official%26biw%3D1173%26bih%3D558%26prmd%3Dimvns& rurl=translate.google.com.vn&sl=en&u=http://www.nlm.nih.gov/medlineplus/druginfo/medmaster /a682753.html&usg=ALkJrhjYUR11etJk7kfOAgTKsnoW0QWixw) L y t " http://en.wikipedia.org/w/index.php?title=Clotrimazole&oldid=456682977 " Th lo i : Antifungals Imidazoles T ch c Y t Th gi i cc lo i thu c thi t y u Antiinfective i l khai

Organochlorides

Trang ny c s a l n cu i vo ngy 21 thng 10 nm 2011 t i 14:26. Vn b n c pht hnh theo Gi y php Creative Commons Attribution-Chia s tng t , i u kho n b sung c th c p d ng. i u kho n s d ng bi t thm chi ti t. Wikipedia l nhn hi u ng k c a Wikimedia Foundation, Inc , m t t ch c phi l i nhu n.

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