Академический Документы
Профессиональный Документы
Культура Документы
Major burns are considered as a syndrome: Local events. Systemic events. (Zogovic et al. 1996).
One of the major systemic complications of sever burns is the renal failure, but it is quite clear that acute renal failure rarely occurs when adequate resuscitation is applied.
Renal Physiology
Gross structure of the kidney:
Cortex. Medulla. Pyramids. Renal calyxes and pelvis. Ureter.
The nephron:
is the basic structural and functional unit. 1. Superficial nephrons (30%). 2. Midcortical nephrons (60%). 3. Juxtamedullary nephrons (10%).
Renal Physiology
Renal Physiology
The initial step is the formation of a plasma ultrafiltrate (plasma without cells or proteins) at Bowman's space through the action of hydrostatic pressure in the glomerular capillaries.
Renal Physiology
The proximal tubules reabsorb back into the peritubular capillaries about 2/3 of the Na and water and most of the bicarbonate, glucose and amino acids filtered and the little albumin.
Renal Physiology
The medullary loop of Henle reabsorbs salts with little water making the medullary interstitium rich in solutes (hyperosmolar) and delivers a solute poor, dilute fluid to the distal tubules. Thus the loop of Henle initiates the processes of urine concentration or dilution.
Renal Physiology
The distal tubules (cortical diluting segments) continue to dilute the luminal fluid through hormone stimulated transport of NaCl (aldosterone)and of Ca salts (parathormone). In the connecting segment water reabsorption becomes prominent only when antidiuretic hormone is abundant.
Renal Physiology
The collecting ducts make the final fine adjustments in composition of the urine through antidiuretic hormone stimulated water and urea reabsorption, and aldosterone stimulated Na, K and H transport.
Urine
Urine Concentration
To use the urine output as an indicator of renal function and the effectiveness of fluid replacement in the burn patient, it is necessary to know both its volume and its concentration (osmolality).
Autoregulation of GFR and RBF Changes in renal arterial resistance to control GFR:
Afferent and efferent arteriolar feedback. Myogenic autoregulation Juxtaglomerular apparatus. Monitors NaCl concentration
(inadequate perfusion)
Renal causes
(obstruction)
Prognostic Factors
The severity of the burns.
Blood urea nitrogen (> 50 mg/dl). Serum creatinine level (> 2.0 mg/ dl).
Proteinuria (quantity and quantity). The factors of age, burn surface area, day of onset of ARF, and the duration of renal replacement therapy are not significant.
Morphological Changes
With an experience of post-mortem histopathology in burns, there are two pattern of change in renal failure after burning: (i) Distal tubular necrosis. Widespread distal tubular necrosis: (affecting many nephrons, commonest in children and young adults). Focal distal tubular necrosis: (affecting only a few nephrons, was found in some patients, mainly children). (ii) Proximal tubular necrosis. Proximal tubular necrosis: was found mainly in elderly cases who had nephrosclerosis.
Prophylactic Management
The initial resuscitation period (between 0 and 36 h), characterized by Na+ and K+.
Pre-Hospital and Emergency Room Care of Burn Patients It is mandatory to monitor carefully ECG and K + and water loss. 1) Fluid resuscitation 2) Reverse potassium effects in cellular membrane with calcium chloride 10% (10 ml intravenously over 10 min) 3) Transfer extracellular potassium into cells: glucose (250-500 m1 of Dl017cW)+insulin (5-10 U) sodium bicarbonate (50-100 mEq over 5-10 min) 4) Remove potassium from the body by means of diuretics, potassium exchange resins or in serious cases, haemodialvsis. 5) Care about: Hyperventilation to avoid respiratory alkalosis. Sepsis defect in osmotic regulation (diabetes insipidus)
Prophylactic Management
The early post-resuscitation period (between days and 6), in which we consider Na+, K+, Ca, Mg and Ph.
Therapeutics is performed with hypotonic fluids low sodium content (NaCl 0.45%, + glucose) + diuretics. The amount of water is given by the formula: = 0.6 x weight (kg) x (Na+ initial/Na+ normal -1). Correction should be performed gradually (not more than 1.5 mEq/h) to avoid cerebral oedema.
Increased K+ losses (urinary, gastric, faecal). The intracellular shift of K+ because of the administration of carbohydrates. This imbalance is also increased by coexist Mg . Potassium deficit is given by the formula: = 0.4 x weight (kg) x (3.5 - K+) . It is fundamental to monitor the ECG and plasma K+.
Fluid Resuscitation
It should be started within the first 24h postburn:
(1) Choice of resuscitation fluid
A. Crystalloid vs colloid (Demling's method). B. Parkland vs Evans & Brooke formulae. C. Hypertonic sodium solution (Monafo's method). D. Modified Parkland formula.
(2) Resuscitation
A. Resuscitation in the first 24 hours. B. Resuscitation in the second 24 hours.
Management
Once the diagnosis of acute tubular necrosis has been made, it is clearly indispensable to begin immediately a therapy whose foundations are: 1. Clinical nutrition. 2. Haemodialysis and Haemofiltration.
NB: No therapy to date has been shown to improve renal outcome and diuretics may worsen pre-renal syndrome.
Management )Haemodialysis(
Continuous Renal Replacement Therapy (CRRT)
The basic principle of action of CRRT is the elimination of inflammatory mediators, urea, creatinine and uraemic toxins with the maintenance of water and electrolytes balance. It depends on four physical principles: ultrafiltration, convection, diffusion and adsorption. CRRT has the capacity to eliminate inflammatory mediators, depending on the type of filter used, up to 30,000-50,000
Daltons (D).
Mediator
Thromboxane A2
PAF
Leukotriens Complement 3a Complement 5a Interleukin 1, 2
524
600 10000 11200 15000 17000 25000 100,000
Management
Types of haemofiltration:
Management
Indications of haemodialysis or haemofiltration:
A. Renal:
Oliguric renal failure. Massive myoglobulinuria (in electric burns).
B. Non-renal:
SIRS to eliminate inflammatory mediators. Sepsis, septic shock. Refractory hyperpyrexia. Correction of electrolyte imbalance. Congestive heart failure not responding to diuretics. ARDS (adult respiratory distress syndrome). Some intoxications. Prevention of the tumour-lysis syndrome.
Management
Disadvantages and complications of CRRT
Long-term interactions between blood and the membrane with possible manifestations of material incompatibility. Removal of substrate by filtration (glucose, amino acids). Risk of haemorrhage during long-term anticoagulation. Loss of heat due to extracorporeal system. Complications associated with insertion of central venous catheter. High price of materials. Some authors have doubts about the elimination of mediators. Antioxidants???
Conclusion
Acute renal failure rarely occurs in cases where adequate resuscitation is applied. In sever burns, a persistent renal tubular damage and inflammation in spite of recovery of general renal function after a transient acute renal dysfunction usually occurs.
An early intensive care of burn-induced renal damage is necessary in order to prevent renal complications as well as to lower the mortality in patients with major burns.
Thank You