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Syllabus Objectives:
(a) Identify the main blood vessels to and from the heart, lungs, liver and
kidney
(b) State the functions of blood
1• red blood cells - haemoglobin and oxygen transport
2• white blood cells - phagocytosis, antibody formation and tissue
2 rejection
1• platelets - fibrinogen to fibrin, causing clotting
2• plasma - transport of blood cells, ions, soluble food substances,
hormones, carbon dioxide, urea, vitamins, plasma proteins
(c) List the different ABO blood groups and all possible combinations for the
donor and recipient in blood transfusions
(d) Relate the structure of arteries, veins and capillaries to their functions
(e) Describe the transfer of materials between capillaries and tissue fluid
(f) Describe the structure and function of the heart in terms of muscular
contraction and the working of valves
(g) Outline the cardiac cycle in terms of what happens during systole and
diastole (Histology of the heart muscle, names of nerves and transmitter
substances are not required)
(h) Describe coronary heart disease in terms of the occlusion of coronary
arteries and list the possible causes, such as diet, stress and smoking,
stating the possible preventative measures
• How do useful materials reach all body cells / waste from the cells are
removed rapidly? Either by
8.2 Blood
• Definition: A fluid tissue
• Average human adult has about 5.5 litres of blood
• Composition of blood:
Blood
Made up of
• Pale yellow
liquid • Cell fragments
• 90% water • Formed in
• Carry dissolved White Blood Red Blood bone marrow
substances • Cells (WBC)
Colourless Cells (RBC)
• Biconcave, Function:
Function: • Contains a flattened discs • Protective
• Transport of nucleus • No nucleus • Clotting of
dissolved • Can move about • Contain blood
substances
and change its haemoglobin
shape • Life-span: 3-4
• Lives for only a months
few days • Formed in bone
marrow
Lymphocytes Phagocytes • Function:in
Destroyed
• Produced in • Produced in • Transport
spleen and liver of
lymph glands bone marrow Oxygen
and lymph
8.2.1
nodes Transport of oxygen (RBC)
2
Phagocytes engulf Lymphocytes produce Platelets + damaged cells
and digest foreign antibodies (proteins) Ca2+ + Vit. K + thrombin
particles (eg.
Bacteria that enter
blood) Fibrinogen fibrin threads network
Antibodies Antibodies kill (Soluble in (Insoluble)
Bacteria cause bacteria bacteria plasma)
clumps to clump + trapped
undergo together RBC
(agglutination) Antitoxins
neutralize Forms blood
toxins clot
produced by
bacteria
• Surfaces of RBC contains antigens, which are the same in all your
RBCs
• Natural antibodies do not react with the antigens on your RBC
o However, it could react with antigens from another person
o When this happens, the antibodies will cause the RBC to clump
together (agglutination) – See Sect 8.2.2 above.
o Clumping of RBC leads to the blockage or small blood vessels
prevent smooth flow of blood death
• Your blood group is based on the types of antigens and antibodies
present in your blood
3
A b - + + -
B a + - + -
AB No - - - -
(universal antibodies
acceptor)
O a and b + + + -
Low-pressure circulation
Legend
A: Atrium
V: Ventricle
Median septum
High-pressure circulation
4
• Oxygenated blood then returns to the heart (to Left
Atrium)
Tricuspid valves
• A muscular organ
• Contracts and relaxes regularly throughout life
• Consists of 4 chambers
2 atria (upper chambers) (LA & RA)
2 ventricles (lower chambers) (LV and RV)
• Median septum separates LA & LV from RA & RV
Prevents mixing of oxygenated blood on left side of heart with
deoxygenated blood on right side
Ensures
• All oxygenated blood is sent to all parts of body
• All deoxygenated blood goes to the lungs
• Structure of atria and ventricles
Chamber Structure Adaptation
5
Atria Walls are thin Only needs to force blood into ventricles
Ventricles Walls are thick Needs to push blood out of the heart
• Walls of LV is thicker than RV enables it to pump blood more forcefully
at high pressure to the rest of the body
• Presence of valves to prevent backflow of blood ensure that blood flows
in one direction only
Tricuspid/Bicuspid valves
Semi lunar valves close “dub” sound open
Tricuspid/Bicuspid valves
close “lub” sound
6
Ventricle relaxing Ventricle contracting
7
8.5.1 Comparison between blood vessels
8
Valves Absent Absent Semi-lunar
valves to
prevent
backflow of
blood
Blood flow 1. Blood moves 1. Blood flows 1. Blood flows
along by smoothly smoothly and
contraction of slowly
the muscles of 2. Pressure at
its walls. arteriole end > 2. Blood moves
pressure at along vein by
2. Blood flows venule end. contractions of
under great the body
pressure, fast, muscles on the
in spurts. vein
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