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OPEN SOURCE
DRUG DISCOVERY
A CSIR led Team India Consortium with Global Partnerships www.osdd.net

CDRI Symposium- Antimalarials: current approaches and new directions

A one day symposium on "Antimalarials: Current Approaches and New Directions" was organized jointly by OSDDm, OSDDChem Outreach and MMV at CSIR-Central Drug Research Institute, Lucknow on 16th November, 2011. This is an effort to apprise the principal investigators under the OSDD program, of the latest developments in the design and discovery of new antimalarials. The conference included lectures by Prof. Stephen Ward, Walter Myers, Professor of Parasitology and Deputy Director at Liverpool School of Tropical Medicine, Dr. Jeremy Burrows and Dr. David Waterson of MMV, Switzerland, Prof. Hema Balaram, JNCASR, Bangalore, Prof. Rahul Jain, NIPER, Mohali, Dr. K. M. Muraleedharan, IITM, Chennai and Dr. Saman Habib, CDRI, Lucknow

OSDD Publications
All the members of OSDD extend hearty congratulations to Ms. Vinita Periwal, Kishtapuram S, Open Source Drug Discovery Consortium, and Dr Vinod Scaria on the acceptance of their Cheminformatics paper Computational models for invitro anti-tubercular activity of molecules based on highthroughput chemical biology screening datasets, in BMC Pharmacology. (2011).

CSIR- OSDD and CDAC signs MOU

OSCAT 2012
Open Source Drug Discovery is organizing the Second International conference on Open Source for Computer-Aided Translational Medicine (OSCAT), at CSIR- IMtech Institute of Microbial Technology, Chandigarh, India from 22 to 25 February 2012. This conference aims at the scientific community working in the field of drug discovery particularly on Mycobacterium tuberculosis. The objectives of the conference are as follows: Promoting open source in therapeutics. Role of computer in translational research Integration of in silico & wet-lab experiments. Bring wide range of experts (in silico to clinical) on single platform. Discuss current status of therapeutics in tuberculosis

OSDD community congratulates OSDD PI, Dr Nanda Ghosal, CSIRIICB and her team for the acceptance of the Deciphering their paper: Structural Requirements of Nucleoside Bisubstrate Analogues for Inhibition of MbtA in Mycobacterium tuberculosis: A FB-QSAR Study and Combinatorial Library Generation for Identifying Potential Hits in Molecular Informatics (2011)

04/11/2011:Further strengthening the collaborative endeavors, an MOU was signed between CSIR/OSDD and CDAC, Bangalore, providing, the Garuda grid supercomputing facility to OSDD on 4th Nov 2011.The MOU was signed at Jawahar Lal Nehru University, New Delhi by OSDD Project Director Mr. Zakir Thomas and Chief Investigator, GARUDA, Dr. Subrata Chattopadhyay. The OSDD team was represented by Project Director Mr. Zakir Thomas and principle investigators Dr Anshu Bhardwaj and Dr Andrew Lynn. GARUDA grid of CDAC has enabled OSDD researchers and students from ordinary institutes across the country to conduct experiments requiring high Computing facilities without interruption and this collaboration will definitely yield valuable results for the drug discovery process in future.

OSDD-Cambridge Collaboration
Under the collaborative projects being pursued by OSDD, a project to develop interactophores of Mtb and human proteins to predict off target binding sites is being pursued under the leadership of Dr Tom Blundell, Cambridge University, Dr Nagasuma Chandra, IISc, Dr N.Srinivasan, IISc and Dr R. Sowdhamini , NCBS

Interested participants may find the details at: http://crdd.osdd.net/oscat/index.html

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DRUG DISCOVERY
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Status of OSDD projects: Several parallel projects on Mtb are ongoing in OSDD. OSDD community adopts a multipronged approach in its research that combines Target based approach, Ligand Based approach and Phytomolecule based approach in its aim to discover a suitable and potent anti tubercular lead. OSDD community is working on a number of experimental projects aimed to discover hits. More than 125 projects on various aspects of drug discovery have been posted online by OSDD community. The research results of the projects pursued are available online. The status of these projects are given below

OSDD List of Targets, Project Status and Funding

OSDD follows the open source dictum Given enough balls, all bugs are shallow. It is the OSDD endeavor to improve the scientific faces on the bug Mtb and in the past three years, OSDD has tried and contributed to the expansion of the early stage drug discovery projects on Mtb. A large number of PIs are working on different targets chosen by them under the OSDD umbrella. The targets that are being pursued by OSDD PIs are listed below

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Funds distributed OSDD follows the unique online peer review and funding procedure, The status of distribution of funds under OSDD is as given below.

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Molecules submitted in OSDDChem

OSDDChem is the open collaborative, initiative to synthesize large number of compounds for screening against TB and malaria. This open collaborative initiative has more than 30 institutions reputed for organic synthesis of compounds with several experienced researchers as active participants. The initiative is led by Central Drug Research Institute, Lucknow . CDRI, under the leadership of Dr Tushar Kanti Chakraborty, has set up on open screening facility for the synthesized compounds. OSDDChem, the OSDD open chemical database can be accessed at: http://crdd.osdd.net/osddchem/ OSDDChem has received enthusiastic response from researchers and students across the nation since its launch. Following the lead of IIRBS, MG University, Kerala other institutions participating with OSDD has submitted molecules with likely anti-TB properties in OSDDChem database. Two molecules have been successfully submitted by Dr. Raghunanthan from University of Madras Dr Palwinder Singh from Department of Chemistry, Guru Nanak Dev University; Amritsar has submitted four molecules while, Dr Radakrishnan from NIST TVM Kerala, uploaded a molecule to OSDDCHEM. OSDD Crosses 5000 Registered Users

Large scale cloning projects receives enthusiastic response

The OSDD community is now more than 5000 users registered on Sysborg. This reflects the commitment of the members from more than 130 countries for affordable healthcare for all. New Users, are requested to follow the link to register in Sysborg 2.0 https://docs.google.com/a/osdd.net /spreadsheet/viewform?hl=en_US &formkey=dG5ORWExN05OOD hvblVBOGNWNE1SblE6MQ&nd plr=1

OSDD News from Overseas Applause for OSDD at Open Science Summit 2011
22nd Oct 2011: It is a matter of great pride and encouragement for all the OSDD members that, OSDD efforts drew applause at the recently held Open Science Summit 2011in Mountain View, CA. Speaking during the session on Opening the sources of Drug Discovery Bernard Munos (Collaborative Drug Discovery) and Matt Todd (Open source chemistry for neglected diseases) lauded the efforts of the OSDD group and how it is able to move forward the drug discovery process at a fraction of the cost compared to the pharma industry (#osc2011 Twitter)

OSDD USA
The OSDD community is growing bigger each day with several new members registering and several new units and collaborative groups starting up. OSDD USA is a now an active unit with Mr Abhik Seal and Mr Girinath Pillai actively leading the unit OSDD wishes Abhik and Girinath all success.

It is the OSDD aim to attract more brilliant young minds into research and provide them an actual working platform to give them a taste of hi end research in their academic years. OSDD has been successful in introducing research projects in various academic institutions that has been appreciated as being highly beneficial by, both teachers and student community. The OSDD students of SASTRA University have successfully created a repository of 150 Mtb clones as a part of creating OSDD open access repositories. This ongoing work is supervised by Dr Vijayalakshmi, SASTRA University, Dr Anshu Bhardwaj, CSIR-OSDD, and Dr Swati Subod, TCGA. Similarly students of ANDC have cloned and purified 12 Mtb proteins. Several such activities are ongoing in several educational institutes across the country.

Open Source
Drug Discovery

Open Source Drug Discovery Initiative CSIR, Anusandhan Bhawan, 2 Rafi Marg,NewDelhi-110001,India.

Editor: Zakir Thomas Content & Design: Geetha & Pushpdeep

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