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Code: R7412301 IV B.Tech I Semester (R07) Regular & Supplementary Examinations, November/December 2011 BIOINFORMATICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE questions All questions carry equal marks ***** 1 2 3 4 5 Write about A. Telnet B.ftp What is homology? Describe with special reference to Sir Richard oven. What is the principle of DNA mapping? Write about short gun DNA sequencing method. What is the importance of sequencing alignment programmes? Explain about BLAST. Add a note on a) NCBL. b) EMBL. Write about secondary databases. Add a note on PIR. Write about A. KEGG B. BRENDA. Describe principle and methodology of phylogenetic analysis. *****

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Code: R7412301 IV B.Tech I Semester (R07) Regular & Supplementary Examinations, November/December 2011 BIOINFORMATICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE questions All questions carry equal marks ***** 1 2 3 4 Explain scope and importance of bioinformatics and add a note on http. Describe homology with special reference to Charles Darwin. Explain DNA mapping and Sanger sequencing method with suitable examples. Write about a) Waterman algorithem. b) Needleman-Wunsch algorithm. Write about importance and applications of a) PDB. b) DDBJ. Write about a) Secondary databases. b) MMDB databases. a) b) Write about Biochemical databases organization. Describe management of databases. Explain principle methodology and evaluation evolutionary tress Construction and its applications. *****

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Code: R7412301 IV B.Tech I Semester (R07) Regular & Supplementary Examinations, November/December 2011 BIOINFORMATICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE questions All questions carry equal marks ***** 1 Write about a) ftp. b) telnet. c) http. Give an account on a) Explain homology with reference to Willie henning. b) Importance of homology in bioinformatics. Explain a) Map alignment and its applications. b) Sangers DNA sequencing. Comment on a) Heuristic alignment algorithms. b) Local sequence alignments with suitable examples. Explain the given below: a) PAM b) Blosum. c) PIR What database? Write about a) Secondary databases. b) SWISSPROT. Explain about a) Importance of biochemical databases. b) BRENDA. c) WIT. Write account on a) Multiple sequence analysis. b) PHYLIP. *****

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Code: R7412301 IV B.Tech I Semester (R07) Regular & Supplementary Examinations, November/December 2011 BIOINFORMATICS (Bio-Technology) Time: 3 hours Max Marks: 80 Answer any FIVE questions All questions carry equal marks ***** 1 2 Explain about scope of bioinformatics and add a note on telnet. Give an account on a) Homology with reference to Richard Owen. b) Homology with reference to Willie henning. Explain a) Applications of DNA mapping. b) Shotgun method. Describe Needeleman-Wunsch algorithm and applications of BLAST. Explain a) Importance o NCBI. b) Searching and retrieval of information from WWW. Explain in brief about PIR Swissprot and KEGG. Describe a) Importance of biochemical databases. b) WIT. Explain a) Applications of multiple sequence analysis. b) Computational tools in phylogenetic analysis. *****

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