HIGO MODULE: EMQ & BOF

Theme 1: Genetics 1) Genetic disorder-Trisomy of sex syndrome 2) X-linked inheritance characterized by haemolytic anaemia Theme 2: Lymphatic system 3)Presence of Afferent and Efferent Vessels 4)Presence of lymph tissue in the ileum Theme 3: Blood Cells 5) Characterized as B-cells, T-cells and Natural Killer Cells 6) Elevated in accelerated blood loss Theme 4: Blood Coagulation Factor 7) The end result of Extrinsic pathway 8) Haemophilia B (lack of factor) Theme 5: Genes of Oncogenesis 9) Causes of breast cancer 10) Causes serious ocular disease Theme 6: Modes of Inheritances 11) Polygenic in origin 12) Autosomal dominant Theme 7: Types of Anaemia 13) Anaemia caused by Vitamin B12 deficiency 14) Reticulocytes of more than 5% Theme 8: Tumor 15) Bone cancer 16) Cartilage cancer A: Osteosarcoma A: Chondrosarcoma A: Macrocytic anaemia A: Haemolytic anaemia A: Diabetes A: Huntingtons Disease A: BRCA2 A: RB1 A: Stuar prower factor A: Christmast factor A: Lymphocytes A: Reticulocytes A: Lymph node A: Peyers Patches A: Klinefelters syndrome A: G-6-PD deficiency

Theme 9: Behavior of tumor 17) Spread in body cavities 18) Spread to surrounding tissue Theme 10: Lymphocytes 19) Featuring blast cells and mature cells 20) Featuring Reed-Sternburg cells Theme 11: Humoral Immunity 21)Reaginic antibody 22) Antibody attached as B-cell receptors Theme 12: Cell-Mediated Immunity 23) MHC-transmitted to offspring-type of inheritance? 24) Enhance antigen presentation, intracellular bacterial killing Theme 13: Vaccination 25) Subunit vaccines-used for infection caused by 26) Inactivated vaccines- used for infection caused by Theme 14: Vaccines 27) Contains recombinant viral antigens 28) Killed virus vaccine Theme 15: Anti-thrombotic Therapy 29) 59 y/o has angina-drugs to prevent thrombus-caused gastric irritation 30) Baby-to prevent bleeding-given by IM route Theme 16: Anti-thrombotic Therapy 31) Mode of action of heparin- activation of 32) Clavidogrel inhibition of A: Anti-thrombin III A: Adenosine diphosphate pathway (ADP) A: Aspirin A: Vitamin K1 A: Hepatitis B vaccine A: Hepatitis A vaccine A: Hepatitis B A: Influenza A: Mendelian inheritance A: Synthesis of MHC molecules A: IgE A: IgM and IgD A: Chronic Leucocytic Leukaemia (CLL) A: Hodgkins Lymphoma A: Transcoelemic spread A: Local invasion

Theme 17: Iron 33)Iron absorption is enhanced by 34) Iron given by parenteral route Theme 18: Vaccination Program 35)Protects individual from disease 36) Resistance in community Theme 19: Parasitology 37) Causes pancytopenia 38) Schuffners dots, RBC enlarged Theme 20: Parasites in Lymphatic System 39) Hydrocephalus in infected newborn 40) Winterbottoms sign 41) Chromosomal complement of XO 42) Negative feedback loop of erythropoiesis 43) Results in Human diversity A: Toxoplasma gondii A: Trypanosoma rhodiense/gambiense A: Turner syndrome A: Low level of oxygen in kidney A: Crossing over A: Burkitts Lymphoma A: Tubular polyp A: IgG A:Natural Killer Cells A: Tacrolimus A: Trypanosoma gambiense A: Leishmania donovani A: Plasmodium vivax A: Individual immunity A: Herd immunity A: Vitamin C A: Iron dextron

44) African Boy/Huge Enlarged Neck Gland/Malignant Lesion Lymph Node 45) Small Nodular Lesion/Short Stalk (endoscopy) 46) Antibody that can cross the placenta 47) Killed virus infected cell 48) Immunosuppressant-inhibit Calcineurin 49) Evades immune system by variant surface of glycoprotein 50) Palliative care

A: Offers support system to help patient live actively as possible

OSPE
Station 1: Anatomy

B A C

1) Identify the organ A: Thymus 2) Part Label A & B A: A=Cortex, B=Medulla 3) Microscopic picture-label C A: Hassalls Corpuscles 4) 2 components of label C A: a)flattened epithelial reticular cells arranged in concentric lamellation b)centrally located hyalinized mass Station 2: Histology

A C B

Structure A B C D E

Name Eosinophil Basophil Neutrophil Lymphocyte Monocyte

When it increases Allergy, parasitic infection Hypersensitivity Acute inflammation Viral infection Chronic inflammation

Station 3: Blood Grouping Blood Group O A B AB 1) Fill in the blank 2) What is the most common blood group? = O 3)What is the least common blood group? = AB Station 4: Biosynthesis of Heme Antigen A B A&B Antibody Anti A & Anti B Anti B Anti A -

1) Starting material = Glycine & Succinyl CoA 2) Enzyme that help in the first step = ALA synthase 3) Reaction C takes place in = Mitochondria 4) 2 enzymes that is affected by lead poisoning = ALA dehydrogenase & ferrochelatase

Station 5: Genetics Inheritance

1) Mode of Transmission = X-linked recessive 2) Name given for = Carrier 3) The common disease = Haemophilia 4) Why the VIII generation (Charles) is unaffected? = Station 6: Leukaemia

1) Morphology of the blast cell = Immature white blood cell, scanty cytoplasm, prominent nuclei 2) Name the cytoplasmic inclusion = Auers Rod 3) Diagnosis = Acute Myeloblastic Leukaemia (AML)

Station 7: Pharmacology (Please meet Dr.Mohanty.. ) Station 8: Neoplasia

1) Describe the gross feature = The border is undefined, look fixed and invading the underlying tissue, large irregular cauliflower shaped, fungating growth 2) Describe the microscopic feature = Keratin Pearls 3) What is the grading? = Well differentiated (Grade 1) 4) Diagnosis = Well differentiated Squamous Cell Carcinoma Station 9: Immunology

1) Name the test = Ouchterlony Double Diffusion Test 2) Interpret the test result = The antibody is present in the well B and C 3) Type of antigens detectant = Soluble antigens 4) 1 use of this test = research, laboratory diagnosis of diseases, pregnancy tests, and forensic identification of blood.

Station 10: Immunopathology

1) Describe the characteristic feature = Butterfly rashes 2) Diagnosis = Systemic Lupus Erythematous (SLE) 3) 1 Diagnostic Test = Antinuclear antibody (ANA) 4) Name the basis of this test = ELISA 5) Possible etiology = Autoimmunity Station 11: Parasitology (Please meet Dr. Cheah .. ) Station 12: Immunization Schedule
Immunization Age in month

0 BCG Hep B TDaP/DT Hib

12

18

IPV MMR

1) 2 types of vaccine after birth = BCG and Hepatitis B 2) Combined vaccine- state 2 components = Tetanus, Hepatitis B 3) 2 contraindication of live vaccine = Immunosuppressed patient, pregnant women, allergy (severe)