Yaki Setty e-mail: yaki.setty@gmail.

com

Address: 81 Emek Ha-Ela st., Modiin, Israel Mobile: +972-52-8990678 Citizenship: Israeli Current Position Since 2011: Research Fellow, Max-Plank Institute and Computer Science Department, Saarbrucken, Germany Since 2011: Scientific Consultant, Weizmann Institute of Science, Rehovot, Israel Since 2009: Scientific Consultant, The Chronic Fatigue and Immune Dysfunction syndrome (CFIDS) Association of America Education 2008-2011: Post-Doctoral Researcher Microsoft research, Computational Science Lab, Cambridge, UK. 2004-2008: Ph.D. student Weizmann Institute of Science, Israel Supervisors: Prof. David Harel, Dep. of Computer Science & Applied Math., Prof. Irun R. Cohen, Dep. of Immunology. Dissertation: "Four-Dimensional Realistic Modeling of Natural Systems" Brief review: http://www.wisdom.weizmann.ac.il/~yaki/abstract 2001 2003: M.Sc. Student (cum laude, final grade: 99), Weizmann Institute of Science, Israel Supervisors: Prof. Uri Alon, Dep. of Molecular biology & Dep. of Physics. Dissertation: "Detailed map of a cis-regulatory input function" 1997 2000: B.Sc. Student (cum laude, final grade: 86) Computer Science and Mathematics, Ben Gurion University, Israel. Work Experience 2004 - 2008: Teaching assistant "Linear Algebra", College of Management, Israel. "Executable Visual Languages for System Development", WIS, Israel. "Mathematical Models in Biology", WIS, Israel.

2001 2002: Software designer Educational bioinformatics project, Department of Science Teaching, Weizmann Institute of Science, Israel. Detailed project description: http://stwww.weizmann.ac.il/bioinformatics/

Publications
Y. Setty, E. Aslakson, S. Szekely, L. Bateman, and S. Vernnon. Modeling Medical Histories To Optimize Patient Care: An Object Model to Study Chronic Fatigue Syndrome Development and Treatment, In preparation, 2011 Y. Setty, Biological synthesis of stem cell systems: challenges, goals and achievements. In preparation, 2011. Y. Setty, J. Magenheim and Y. Dor.. In-silico study of pancreatic morphogenesis and differentiation. In preparation, 2011 Y. Setty, A computational approach to multi-scale modeling of stem cell systems. Submitted, Nature Communications 2011 N. Bloch*, D. Sherman*, Y. Setty* and David Harel (*equal contribution) Analysis of glucose homeostasis dynamics in healthy and type-I diabetes mellitus in-silico subjects. Under Review, Integrative Biology, 2011 [IF 4.4]. Y. Setty, D. Dalfo, E.J.A. Hubbard, and H. Kugler. A model of stem cell population dynamics: in-silico analysis and in-vivo validation. In press, Development, 2011 [IF 8]. Y. Setty, C.C. Chen, M. Secrier, D. Kalamatianos, N. Skoblov, and S. Emmott. How neurons migrate: A cellular decision making model of neuronal migration. BMC Systems Biology 2011, 5:154 [IF 3.57] . Y. Setty, I.R. Cohen, D. Harel. Executable Modeling of Morphogenesis: A Turing-Inspired Approach. Fundamenta Informaticae, 2011. Y. Setty, I. R. Cohen, and D. Harel. Modeling Biology using Generic Reactive Animation. Fundamenta Informaticae, 2010. Y. Setty, I. R. Cohen, Y. Dor, and D. Harel. Four-dimensional realistic modeling of pancreatic organogenesis. Proc Natl Acad Sci U S A, 105(51):2037420379, 2008. [IF 9.77] D. Harel, I. Segall, H. Kugler, and Y. Setty Crafting Game-Models using Reactive System Design. Future Play, Association for Computing Machinery, Inc., 9:661674, 2008. D. Harel, Y. Setty, S. Efroni, N. Swerdlin, , and Cohen I. R. Concurrency in Biological Modeling: Behavior, Execution and Visualization. Electron. Notes Theor. Comput. Sci., 194:119131, 2008.

Y. Setty and D. Harel. Generic Reactive Animation: Realistic Modeling of Complex Natural Systems. Lecture Notes in Bioinformatics, 5054:1 16, 2008. A. E. Mayo, Y. Setty, S. Shavit, A. Zaslaver, and U. Alon. Plasticity of the cis-regulatory input function of a gene. PLoS Biol, 4(4):e45, 2006. [IF 12.92] Y. Setty, A. E. Mayo, M. G. Surette, and U. Alon. Detailed map of a cis-regulatory input function. Proc Natl Acad Sci U S A, 100(13):77027707, 2003. [IF 9.77]

Invited talks (highlights) Modeling organogenesis: scaling development from stem cells to organs. Medical Institute South Carolina, USA, 2011 Cellular decision-making from stem cells to organs. Max Planck Institute Fur Informatic, Saarbrucken Germany 2010 Can a research network help realistic modelling of CFS? , From Infection to Neurometabolism: A Nexus for CFS, CFIDS meeting, Cold Spring Harbour Sept. 2009. Four dimensional realistic modelling of pancreatic organogenesis, Centre for Clinical Epidemiology and Evaluation, UBC, Mar. 2009. Realistic modelling of biological systems, TechFest, Microsoft Research, US, Feb. 2009. Crafting Game-Models using Reactive System Design, Future Play, Canada, Nov. 2008 Four dimensional realistic modelling of pancreatic organogenesis, Cold Spring Harbour, US, Dec 2008. Academic activities Referee for the BMC Systems Biology (2011) Referee for the BMC Systems Biology (2010) Referee for the Bulletin of Mathematical Biology (2009) Grant Referee for The CFIDS Association of America (2008) Grant Referee for WWTF Vienna Science and Technology Fund (2007) Languages Hebrew: mother tongue. English: speaking, reading and writing fluently. Arabic: basic speaking.

Military Service Full 3 years military service 1993-1996. References Prof. Yuval Dor Hebrew University, Jerusalem, Israel yuvald@ekmd.huji.ac.il Prof. Jane A. Hubbard New York University, New York, USA jane.hubbard@med.nyu.edu

Prof. David Harel Prof. Marta Kwiatkowska Weizmann Institute of Science, Rehovot, Israel University of Oxford, UK david.harel@weizmann.com Marta.Kwiatkowska@cs.ox.ac.uk Prof. Irun Cohen Dr. Suzanne D. Vernon, Weizmann Institute of Science, Rehovot, Israel Scientific Director irun.cohen@weizmann.com The CFIDS Association of America, Charlotte, USA sdvernon@cfids.org Prof. Uri Alon Dr. Hillel Kugler Weizmann Institute of Science, Rehovot, Israel Microsoft Research, Cambridge, UK uri.alon@weizmann.com hkugler@microsoft.com Prof. Moshe Vardi Rice University, Texas, USA vardi@cs.rice.edu Prof. Marta Kwiatkowsk Oxford University, UK Marta.Kwiatkowska@cs.ox.ac.uk