1.

VIGOCID

Indications Listed in Dosage. Dosage Adult: IV Nosocomial pneumonia 4.5 g (piperacillin 4 g and tazobactam 0.5 g) 6 hrly for 7-14 days. Severe infections 3.375 g (piperacillin 3 g and tazobactam 0.375 g) 6 hrly for 7-10 days. Contraindications Hypersensitivity. Special Precautions Pregnancy and lactation, pseudomembranous colitis. Assess hematopoietic function periodically. Perform periodic electrolyte determinations in patients with low K reserves. Increased risk of fever and rash in patients with cystic fibrosis. Increased risk of bleeding manifestations. Prolonged treatment may increase risk of superinfections. Convulsions or neuromuscular excitability may occur when high doses are used, especially in renally impaired patients. Renal impairment. Adverse Drug Reactions Diarrhoea, skin rashes, occasionally platelet mediated bleeding, rigors, malaise, ulcerative stomatitis. Inj-site reactions such as pain, erythema, induration and thrombophlebitis. Potentially Fatal: Serious, anaphylactic reactions. Drug Interactions Probenecid prolongs half lives of piperacillin and tazobactam. Increased risk of methotrexate toxicity when used together. Potentially Fatal: Interacts with heparin and other oral anticoagulants. Prolongs the neuromuscular blockade of vecuronium and non-depolarizing muscle relaxants. Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters). Mechanism of Action For details of the mechanism of action, pharmacology and pharmacokinetics and toxicology ... click to view piperacillin + tazobactam MIMS Class Penicillins ATC Classification J01CA12 - piperacillin ; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections. J01CG02 - tazobactam ; Belongs to the class of beta-lactamase inhibitors. Used in the systemic treatment of infections.
2. AZITHROMYCIN Azithromycin is an azalide, derived from erythromycin. Common brand names are Azomycin, Azyth, Geocit, Macromax, Zenith, Zithromax, and Zmax. Azithromycin is classified as a macrolide and antibiotic. Indication for Azithromycin Azithromycin is used for the treatment of mild to moderate infections of upper respiratory tract and lower respiratory tract infections, uncomplicated skin or skin structure infections, and sexually transmitted diseases. It prevents disseminated Mycobacterium avium complex. Routes and Dosage of Azithromycin Respiratory Tract Infections PO: ADULTS, ELDERLY: 500 mg once, them 250 mg daily for 4 days. CHILDREN >6 MONTHS: 10 mg/kg once (maximum 500 mg) then 5 mg/kg/day for 4 days (maximum 250 mg). Acute Bacterial Exacerbations of COPD

Action of Azithromycin Azithromycin binds to ribosomal receptor sites of susceptible organisms. It inhibits protein synthesis. Side Effects and Adverse Reactions of Azithromycin Side Effects of Azithromycin Nausea Vomiting Diarrhea Abdominal pain Headache Dizziness Allergic Reaction Adverse Reactions of Azithromycin Superinfections Acute intestinal nephritis Nursing Considerations for Clients Taking Azithromycin Question for history of hepatitis, allergies to azithromycin or erythromycin. May give tablets without regard to food. Check for GI discomfort, nausea, and vomiting. Determine pattern of bowel activity ans stool consistency. Monitor hepatic function tests, assess for hepatotoxicity: malaise, fever, abdominal pain, and GI disturbances. Evaluate for superinfection: genital/anal pruritus, sore mouth or tongue, moderate to severe diarrhea. Patient Teachings for Clients Taking Azithromycin Continue therapy for full length of treatment. Doses should be evenly spaced. Take oral medication with 8 oz water at least 1 hour before or 2 hours after food or beverage. 3. DECILONE FORTE