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EMERGENCY DRUGS Can cause photophobia Instruct client not to drive a motor vehicle or participate in activities requiring alertness. Advise to use hard candy, ice chips, etc. for dry mouth.
CARDIAC DRUGS ATROPINE SULFATE Isopto Atropine Classification Anticholinergics Dosage Bradycardia: 0.5 mg IV every 3-5 mins, max of 0.04 mg/kg Cardiac Arrest: 1 mg every 3-5 mins
NITROGLYCERINE Nitrostat Classification Antianginal Nitrate Vasodilator, Coronary Dosage 0.3-0.4 mg SL q 5 min, max 3 doses. Every 6 hrs except for midnight (cream) Wear 12 hrs a day for skin patch Action Relaxes the vascular smooth system Reduces Reduces Reduces Reduces myocardial oxygen consumption left ventricular workload arterial BP venous return
Indication Pre-op meds/pre-anesthetic meds To restore cardiac rate and arterial pressure during anesthesia when vagal To lessen the degree of A-V heart block To overcome severe carotid sinus reflex Antidote for cholinergic toxicity Side effects CNS: restlessness, ataxia, disorientation, hallucinations, delirium, coma, insomnia, agitation, confusion. CV: tachycardia, angina, arrhythmias, flushing. EENT: photophobia, blurred vision, mydriasis.
Indication Angina pectoris CHF associated with AMI Cardiac load reducing agent Hypertensive Crisis Side effects CNS: headache, throbbing, dizziness, weakness. GI: nausea, vomiting Skin: Rash Adverse Reactions CV: orthostatic hypotension, flushing, fainting. EENT: sublingual burning.
GI: dry mouth, constipation, vomiting. GU: urine retention. Hematologic: leukocytosis Other: anaphylaxis
MORPHINE SULFATE Immediate-release tablets: MSIR Timed-release: Kadian, M-Eslon (CAN), MS Contin, Oramorph SR Oral solution: MSIR, Rescudose, Roxanol, Roxanol T Rectal suppositories: RMS Injection: Astramorph PF, Duramorph, Epimorph (CAN) Preservative-free concentrate for microinfusion devices for intraspinal use: Infumorph Classification Opioid Agonist Analgesic Dosage Oral: 1030 mg q 4 hr PO. Controlledrelease: 30 mg q 812 hr PO or as directed by physician; Kadian: 20100 mg PO daily 24-hr release system; MS Contin: 200 mg PO q 12 hr.
Rectal:1030 mg q 4 hr or as directed by
physician. Action Acts as agonist at specific opioid receptors in the CNS to produce analgesia, euphoria, sedation
GU: dysuria, nocturia and polyuria GI: abnormal liver function, anorexia,
Contraindications Hypersensitivity Sick sinus syndrome 2nd or 3rd degree AV block CHF Cardiogenic shock Concurrent IV beta-blocker
Nursing Management Monitor BP and pulse before therapy, during titration and therapy Monitor ECG, I&O, serum potassium and weight. Assess for CHF DILTIAZEM Cardizem, Dilacor, Novo-Diltiazem, Tiamate and Tiazac Classification Anti-anginals Antiarrhythmics Antihypertensive Ca channel blocker Dosage PO: 30-120 mg, 3-4x daily or 60-120 mg twice daily as SR capsules IV: 0.25 mg/kg Action Inhibits calcium transport into myocardial smooth muscle cells Systemic and coronary vasodilation Indication Hypertension Angina Pectoris Supraventricular Arrhythmia Atrial flutter/fibrillation Side Effects and Adverse and Reactions CNS:abnormal dreams, anxiety, confusion, dizziness and headache EENT: blurred vision, epistaxis and tinnitus CV: arrhythmia, CHF, chest pain, bradycardia, hypotension and palpitations GU: dysuria, nocturia and polyuria GI: abnormal liver function, anorexia, constipation, diarrhea, nausea and vomiting Contraindications Hypersensitivity
Sick sinus syndrome 2nd or 3rd degree AV block CHF Cardiogenic shock Concurrent IV beta-blocker
Nursing Management Monitor BP and pulse before therapy, during titration and therapy Monitor I&O and weight Assess for CHF Routine serum digoxin monitoring LIDOCAINE Xylocaine Classification CV drugs: Anti-arrhythmics Anesthetic Dosage Arrhythmia: IV: 0.7-1.4 mg/kg body weight. No more than 200 mg within 1 hour period IM: 4-5 mg/kg body weight Action Increases electrical stimulation of ventricle and His-purkinje system by direct action on tissues, resulting to decrease depolarization, automaticity and excitability in ventricles during diastolic phase Indication Anesthesia Arrhythmias Control of Status epilepticus refractory to other treatments Side Effects and Adverse Reactions GI disturbances, bradycardia, hypotension, convulsion, numbness of tongue, muscle twitching, restlessness, nervousness, dizziness, tinnitus, blurred vision, fetal intoxication, light headedness, drowsiness, apprehension, euphoria, vomiting, sensation of heat, respiratory arrest and CV collapse Contraindications Hypersensitivity Heart block Hypovolemia Adams stroke syndromes Infection at site of injection Nursing Management Assess pt before and after therapy Pts infusion must be on cardiac monitor Monitor ECG, if QT or QRS increases by 50% or more, withhold the drug Monitor BP, check for rebound HPN after 12 hrs
PROCAINAMIDE Pronestyl, Procan-SR, Procanbid Classification Antiarrhythmics Dosage Arrhythmias: 50 mg/kg/day in divided doses 3-6 hourly Action Blocks open Na channels and prolongs the cardiac action potential. This results in slowed conduction and ultimately the decreased rate of rise of the action potential may result on the widening of QRS on ECG Indication Supraventricular and ventricular arrhythmias. Treatment of Wolf-Parkinson-White Syndrome Side Effects and Adverse Reactions Severe hypotension, ventricular fibrillation and asystole. Drug induced SLE syndrome, blood disorders, fever, myocardial depression, heart failure, agrunulocytosis, psychosis, angioedema, hepatomegaly, skin irritation, hypergammaglobulinemia, GI and CNS effects Contraindications Heart block Heart failure Hypotension Myesthenia gravis Digoxin toxicity Lactation Nursing Management Assess cardiovascular status before therapy Assess pulmonary, hepatic and thyroid function before and during therapy Monitor fluid and electrolytes, I&O, K, Na and Cl Monitor ECG, BP Assess vision EPINEPHRINE Injection, OTC nasal solution: Adrenalin Chloride Ophthalmic solution: Epifrin, Glaucon Insect sting emergencies: EpiPen Auto-Injector (delivers 0.3 mg IM adult dose), EpiPen Jr. Auto-Injector (delivers 0.15 mg IM for children) OTC solutions for Nebulization:
Anaphylaxis: 0.1- 1 mg SQ or IM of
1:1000 solution. solution
Indication Asthma Bronchitis Emphysema All cardiac arrest, anaphylaxis Used for symptomatic bradycardia. Relief of bronchospasm occurring during anesthesia Exercised-induced bronchospasm Side Effects/Adverse Reactions Side Effects: nervousness, tremor, vertigo, pain, widened pulse pressure, hypertension nausea Adverse Effects: headache Contraindications With angle-closure glaucoma, shock (other than anaphylactic shock), organic brain damage, cardiac dilation, arrhythmias, coronary insufficiency, or cerebral arteriosclerosis. Also contraindicated in patient receiving general anesthesia with halogenated hydrocarbons or cyclopropane and in patients in labor (may delay second stage) In conjunction with local anesthesia, epinephrine is contraindicated for use in finger, toes, ears, nose, and genitalia. In pregnant woman, drug is contraindicated. In breast feeding do not use the drug or stop breast feeding. Nursing Management 1. Monitor V/S. and check for cardiac dysrrhythmias
MAGNESIUM SO4 Classification Anti-convulsant Anti-arrhythmics Dosage Arrhythmia: IV 1-6 grams over several minutes, then continuous IV infusion 3-20 mg/min for 5-48 hours. Action Decreased acetylcholine released Indication Mg replacement Arrhythmia Side Effects and Adverse Reactions CNS: drowsiness, depressed reflexes, flaccid paralysis, hypothermia CV: hypotension, flushing, bradycardia, circulatory collapse, depressed cardiac function EENT: diplopia Respiratory: respiratory paralysis
VASOPRESSIN Pitressin Classification Pituitary Hormones ADH Dosage Prevent and treat abdominal distention: initially 5 units IM gives subsequent injections q3-4 hours increasing to 10 units if needed. Action Increase permeability of renal tubular epithelium to adenosine monophosphate and water, the epithelium promotes reabsorption of water and concentrated urine Indication Diabetes Insipidus Abdominal Distention GI bleeding Esophageal varices
Side Effects and Adverse Reactions CNS: tremor, headache, vertigo CV: vasoconstriction, arrhythmias, cardiac arrest, myocardial ischemia, circumollar pallor, decreased CO, angina GI: abdominal cramps GU:uterine cramps
Contraindications Heart block and myocardial damage Toxemia of pregnancy Nursing Management Monitor I&O. make sure urine output is 100 ml or more in 4 hrs pd before each dose Take appropriate seizure precautions Keep IV Ca gluconate at bedside Na HCO3 Arm and Hammer; Baking Soda Classification Alkalinizers Dosage Metabolic Acidosis: Usually 2-5 meq/kg IV infuse over 4-8 hr period Cardiac Arrest: 1 meq/kg IV of 7.5 or 8.4% sol, then 0.5 meq/kg IV q 10 mins depending on ABG
Contraindications With chronic nephritis and nitrogen retention Hypersensitivity Nursing Management Give 1-2 glass of H20 to reduce adverse reactions and improve therapeutic response
Nursing Management 1. Obtain VS before giving the drug 2. Place pt in supine 3. Giving excessive doses of 500 mcg/kg delivered faster than 2 mcg/kg/min or using max infusion rate of 10 mcg/kg/min for more than 10 mins can cause cyanide toxicity FUROSEMIDE Lasix Classification Loop Diuretics Dosage Pulmonary edema: 40 mg IV Edema: 20 to 80 mg PO every day in the morning HPN: 40 mg PO bid. Dosage adjusted based on response Action Inhibits Na and Cl reabsorption at the proximal and distal tubules and in the ascending loop of Henle Indication Acute pulmonary edema Edema Hypertension Side Effects/Adverse Reactions Signs of hypotension, hypokalemia and hyperglycemia Contraindications Hypersensitivity Anuria Nursing Management 1. Monitor wt., BP and PR 2. Monitor fluid, I&O, electrolyte, BUN and CO2 levels frequently 3. WOF signs of hypokalemia 4. Monitor uric acid levels 5. Monitor glucose levels esp in DM pts MORPHINE SO4 (Discussed earlier)
Contraindications Metabolic and respiratory alkalosis Pt losing Cl because of vomiting or continuous GI suction or those receiving diuretics that produces hypochloremic alkalosis Nursing Management Obtain blood pH, PaO2, PaCo2 and electrolyte levels SIVP
HYPERTENSIVE CRISIS Na NITROPRUSSIDE Nittropress Classification Antihypertensive, Vasodilator Dosage 0.25-0.3 mcg/kg/minute Action Relaxes arteriolar and venous smooth muscle Indication Hypertensive crisis To produce controlled hypotension during anesthesia To reduce preload and afterload in cardiogenic shock Side Effects/Adverse Reactions Headache, dizziness, increased ICP, loss of consciousness, restlessness, bradycardia, nausea, abdominal pain, methemoglodinemia, muscle twitching, pink-colored rash, irritation at infusion site Contraindications Hypersensitivity Compensatory hypotension
POISONING NALOXONE HCL Narcan Classification Miscellaneous antagonists and antidotes Dosage For suspected opioid induced respiratory depression: 0.4 to 2 mg IV, IM and SQ. repeat doses q 2-3 mins PRN For postoperative opiod depression: 0.01 to 0.2 mg IV q 2-3 mins, PRN. Repeat dose within 1-2 hr, if needed. Action Reverse the effects of opiods, psychotomimetic and dysphoric effects of agonist-antagonists Indication For suspected opioid induced respiratory depression For postoperative opiod depression
pressure: 1.5-2 gram/kg as a 15 % to 20% IV solution over 30-60 min Diuresis in drug intoxication: 12.5% to 10% solutions up to 200 g IV Irrigating solution during TURP: 2.55%
Action Increases osmotic pressure of glomerular filtrate, inhibiting tubular reabsorption of water and electrolytes; drug elevates plasma osmolarity, increasing water flow into extracellular fluid Indication Test dose for marked oliguria or suspected inadequate renal function Oliguria To induced intraocular or intracranial pressure Diuresis in drug intoxication Irrigating solution during TURP Side Effects/Adverse Reactions CN: seizures, headache and fever
EENT: blurred vision and rhinitis GI: thirst, dry mouth, nausea, Metabolic: dehydration Skin: local pain Others: chill
vomiting and diarrhea GI: urine retention
Side Effects/Adverse Reactions CNS: seizures, tremors CV: ventricular fibrillation, tachycardia, HPN with higher recommended doses, hypotension GI: nausea and vomiting Respiratory: pulmonary edema Skin: diaphoresis Contraindications Hypersensitivity Use cautious with cardiac irritability or opiod addiction. Nursing Management Assess respiratory status frequently Respiratory rate increases within 1-2 mins IPECAC SYRUP Classification Antidote Dosage 25-30 ml followed immediately by H2O Action Irritates the stomach lining and stimulate the vomiting center
Contraindications Hypersensitivity Anuria, severe pulmonary congestion, frank pulmonary edema, active intracranial bleeding during craniotomy, severe dehydration, metabolic edema, progressive heart failure or pulmonary congestion after drug Nursing Management Monitor VS,CVP,I&O, renal function fluid balance and urine K levels daily. Drug can be used to measure GFR
SHOCK DOPAMINE Intropine Classification Adrenergic drugs Dosage Initially 2-5 mcg/kg/min by IV Action Stimulates dopaminergic and alpha and beta receptors of the sympathetic nervous system resulting in positive inotropic effect and increased CO Indication To treat shock and correct hemodynamic imbalances To correct hypotension To improve perfusion of vital organs
Side Effects CNS: headache an anxiety CV: tachy, angina, palpitations and vasoconstriction GI: nausea and vomiting Contraindications Hypersensitivity With uncorrect tachyarrhythmias Pheochromocytoma Ventricular Fibrillation Nursing Management Most patients received less than 20 mcg/kg/min Drugs isnt substitute for blood or fluid volume deficit During infusion, monitor ECG, BP, CO, PR and color and temp of the limbs Do not confuse dopamine to dobutamine Check urine output often DOBUTAMINE Dobutrex Classification Adrenergic drugs Dosage 0.5-1 mcg/kg/min IV infusion, titrating to optimum dosage of 2-20 mcg/kg/min 2.5 to 10 mcg/kg/min-usual effective range to increase CO Action Stimulates heart beta receptors to increase myocardial contractility and SV Indication To increase CO Treatment of cardiac decompensation Side Effects CNS: headache
GLUCAGON Classification Pancreatic Hormones Dosage 0.5-1 mg SQ, IV, IM, repeat in 20 mins PRN Action Binds with glucagon receptor Indication Hypoglycemia Side Effects Nausea, vomiting, hypotension, tachycardia and hypertension Contraindications Hypersensitivity Pheochromocytoma Insulinoma Nursing Management Monitor V/S and blood sugar level Response within 20 mins after injection ALBUTEROL Ventolin Classification Bronchodilator, Adrenergic Dosage 2 inhalations reputed q 4-6 hrs via neb Action Activation of beta adrenergic receptors on airway smooth muscle Indication Asthma Prevention of exercise induced spasms Side effects Palpitations Tachycardia GI upset Nervousness Contraindications Hypersensitivity Nursing Management Monitor therapeutic effectiveness
DIPHENHYDRAMINE HCL Benadryl Classification Anti-histamine Dosage 25-50 mg PO, IV or IM bid-tid Action Blocks the effects Hi receptor sites Indication Allergic reactions
Side Effects Xerostomia Urinary retention Sedation Contraindications Acute asthmatic attack Nursing Management Risk for photosensitivity- use sunscreen EPINEPHRINE (Discussed earlier)