General

1) CARDIAC:
a)BP b) HR c) Vasoconstricts Arteries to Heart INCREASES FORCE OF HEART CONTRACTION!

Muscles
Eye: DILATES/mydriasis
CONTRACTS: (radial muscle) LUNGS:

Secretions:
DECREASES Bronchial Gland secretions

Vessels
SKELETAL MUSCLE (Blood Vessels) CONSTRICTS *** TBV***

Metabolism
LIVER: 1) Glycogenolysis 2) Gluconeogenesis

GI: SLOWS digestion

CONTRACTS: S. muscle sphincters CONTRACTS: sphincters CONTRACTS: pilomotor smooth muscle CONTRACTS: 1) prego uterus 2) Ejaculation

APOCRINE SWEAT GLANDS:

INCREASES SKIN, Sweat SPLANCHNIC ****EXCEPTION**** (Viscera)

CONSTRICTS

-1

Urinary: STOPS urinary

Skin/Hair: Hair erects

GENITAL:

TQ:

Block of -1 inhibits induced vasoconstriction

Peripheral Resistance = Increased difficulty in Perfusion in Periphery

1) Hypotension during anesthesia Midodrine: Chronic Orthostatic hypotension, take a.m. 1) Brainstem: Reduces Sympathetic Outflow BP

Phenylephrine (prefers alpha 1 over alpha 2) GI: a) RELAXES smooth muscle b) INHIBITS secretions

methoxamine

RELAXES AND INHIBITS

EYES: aqueous humor production GI: a) INHIBITS secretions b) RELAXES smooth muscle

IOP

-2

2) Autoreceptor: Reduces NE output presynaptic adrenergic ganglia 3) Heteroreceptor: Reduces AcH Output presynaptic cholinergic ganglia

INHIBITS/DECREASES

PANCREAS: cell INHIBITS/DECREASES secretions (Islets) **************** **** KIDNEYS/BP: INHIBITS RENIN ****************

recept ors

1) INCREASE BLOOD IN HEART AND LUNGS AND SKELETAL MUSCLE 2) INCREASE outflow of aqeuous humor 2) DECREASE secretions of Acini BIND: Epi > NE > Isoproterol ***INCREASE ARTERIAL RESISTANCE

General
MAIN ROLE IS ON HEART

Muscles
HEART:

Secretions:
Kidney: Increase Renin

Vessels
No significant effects

Metabolism
No significant effects

SA node -- Heart Rate

-1

At Atria-- contractility At Atria AND AV node -- conduction velocity At AV node -- automaticity Ectopic Pacemakers - cause arrythmia HR

1) DOMINATE AT HEART 2) Strong role in kidneys increasing Renin secretion (another factor that increases BP) THUS BETA BLOCKERS HAVE DUAL ACTION AGAINST HYPERTENSION!!!!!!!

General

Muscles
Eye: DILATES Contracts ciliary muscle Eye: aqueous humor, IOP Lungs: Relaxes/Bronchodilation GI Smooth: RELAXES GU: RELAXES Bladder, Uterus

Secretions:
Lungs: Bronchial Gland

Vessels
Skeletal Blood Vessels: DILATES!!

Metabolism
Liver:gluconeogenesis, glycogenolysis Pancreas: Islet B cells Secretions

Increases secretions

-2

2) Prostate hyperplasia (have mitogenic effects, works at ureter/urethra)

General M-1
GI/Mysenteric plexus: Heart:
SA: HR

Muscles
Para actions, more smooth muscle tone

Secretions:
Bronchial Glands: Eccrine Glands: Small stimulation Increases Symp in sweat glands

Vessels

Metabolism

M-2

Atria: contractility and shortened action potential

Pancreas Acini Glands:

Increase secretion

M-2

AV Node: Conduction velocity AV BLOCK Contractility: DECREASES ATRIA ONLY

*Big player in Heart w/ B - 1*

Auto Receptor!!!

EYE: Pupil constriction,

near vision, contracts Ciliary GI: Sphincters Relax

M-3

EYE: IOP , by increasing outflow of aqueous humor

NO VASODILATION: no para innervation @ vessels, so circulating cholinergic cause **Example Erection** LUNG: Bronchoconstriction

GI: Secretions increased Eccrine Glands:

Increases Symp in sweat glands Increase secretion

Bladder Wall Contract

Pancreas Acini Glands: