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Answers must be typed and handed in on 5/31 in class. If you do not bring it in, you will
take the exam in class.
6. The ________ contains nuclei that regulate body temperature, food intake, and sexual response
a. thalamus
b. hypothalamus
c. midbrain
d. pons
e. medulla oblongata
7. The _______ contains nuclei that control coughing, sneezing, swallowing, and vomiting
a. thalamus
b. hypothalamus
c. midbrain
d. pons
e. medulla oblongata
8. The cerebral cortex concerned with hearing is in
a. the insula
b. the occipital lobe
c. the temporal lobe
d. the parietal lobe
e. the frontal lobe
12. The area of the brain that is needed to understand the meaning of words is
a. Broca's area
b. Wernicke's area
c. premotor cortex
d. primary motor cortex
14, The ________ coordinates body movements and aids in learning motor skills
a. cerebrum
b. cerebral cortex
c. cerebellum
d. midbrain
18. The minimum level of local potential that produces a response is called
a. decremental
b. graded
c. a threshold
d. a reflex
19. A football player exhibited the following symptoms after a third-quarter play in which he was injured:
1. uncontrolled rhythmic contraction of skeletal muscles
2. abnormally great tension in muscles
23. The glial cells that destroy microorganisms in the CNS are
a. microglia
b. satellite cells
c. ependymal cells
d. oligodendrocytes
e. astrocytes
1b 7e 13b 19d
2c 8c 14c 20c
3d 9b 15a 21c
4a 10a 16d 22c
5a 11b 17d 23a
6b 12b 18c 24c
II. Short Answer (3 pts): Answer 2/3 or all 3 for extra credit
25. A 77-year-old woman was cooking in the kitchen when she collapsed onto the floor. Her daughter
called an ambulance and the woman was taken to the emergency room. She had suffered a stroke, and
slowly regained consciousness over the next two days. However, when she woke up, she had the following
signs and symptoms:
The stroke deprived oxygenated blood from several areas of her brain. Paralysis
of right face and arm, and the loss of sensation to touch on her right arm and side of face,
suggests damage to certain motor centers of her left frontal cerebrum (nerve pathways
from left side of brain pass to right side of body) or thalamus, since nerve pathways for
sensation and movement pass from the cerebrum through the thalamus to the respective
areas of the body. Inability to answer questions yet the ability to understand speech points
to a problem in formulating speech, and this nonfluent aphasia is a dysfunction of Broca’s
area. Her ability to write down her thoughts (a function of Wernicke’s area) more easily
than her ability to speak them is a further indication of damage to Broca’s area, rather
than other language centers.
The woman could have suffered one of two types of strokes – ischemic stroke,
which is caused by a blockage in an artery in the brain, and hemorrhagic stroke, which is
caused by a ruptured blood vessel that increases cerebrospinal fluid pressure in the brain,
impinging surround brain matter and causing problems appropriate to the trauma that is
being suffered. The hemorrhage should fill up the nearby ventricle (third ventricle,
judging from affected area) and cause radiating damage that increases over time as more
blood flows in. Probability-wise, the woman most likely suffered an ischemic stroke,
which accounts for 88 percent of all strokes, and she would then have been treated with
blood thinners like warfarin and antiplatelet medication like aspirin to dislodge the
blockage that caused the stroke. If she did suffer a hemorrhagic stroke, the type of
medication for ischemic stroke would act against the clotting that is necessary to stop
bleeding; these strokes can be treated by repairing the rupture site, but often the body
does this itself and the patient is usually just monitored and treated for complications
resulting from the stroke (such as brain inflammation).
26. Explain the biochemical/physiological basis of addiction. Include in your answer an explanation of the
reward mechanism, neuroadaptation, and withdrawal. Be specific in describing the important
neurotransmitters and parts of the brain involved.
27. Describe how synaptic inputs are integrated by neurons. Include in your answer descriptions of the
postsynaptic potentials, the types of summation, and the types of neural circuits
Neural synapses are the connections between neurons in a neural circuit. There are
three types of synapses – axodendritic (axon to dendrite), axosomatic (axon to soma), and
axoaxonic (axon to axon). Neurons communicate with neurons by neurotransmitters,
released from vesicles on the transmitting axon terminal, which are collected on receptor
sites of the receiving neuron to generate a postsynaptic electric potential i.e. a voltage.
This action potential can activate voltagegated calcium channels which will cause
synaptic vesicles to transport neurotransmitters to the axon terminal for a repeat of the
transmission process; however, different neurotransmitters have different electrical
properties so they may have either an excitatory or inhibitory effect on neuronal activity.
There are three types of synaptic neurotransmitter activities – excitatory cholinergic
(ACh), inhibitory GABAergic, and excitatory adrenergic. Excitatory cholinergic
synapses release ACh which bind to receptors that trigger a release of sodium ions that
create a negative electric potential at the synapse that at reaching 55mV (from normal
70mV, relative to environment) forces an action potential for target neuron; ACh can
have an inhibitory effect on action potential for some neurons. An inhibitory GABAergic
synapse releases GABA which opens chlorine ion channels instead and these
hyperpolarize (further “negativeize”) the synapses so that depolarization becomes more
difficult and no action potential is created. An excitatory adrenergic synapse releases
norepinephrine which binds to a G protein which binds to adenylate cyclase that converts
ATP to cAMP. cAMP has multiple effects, which vary depending on cell, including the
opening of ligandregulated sodium ion gates that will generate an action potential, and
activation or synthesis of enzymes to effect changes in metabolism. In the view of a
computation, these three synaptic activities are different operations, and “the more
synapses a neuron has the greater its informationprocessing capabilities.” Other
neurotransmitters that create excitatory postsynaptic potentials are glutamate and
aspartate, and inhibitory PSPs are generated by glycine in addition to GABA.
Synaptic summation refers to aggregation of PSPs, and a typical neuron requires
30 EPSPs to depolarize or fire (form an action potential). Since the typical EPSP is .5mV
and lasts 20ms, summation can occur by temporal accumulation of EPSPs by a synapse
from an axon within a determinedly short period of time, or by spatial accumulation of
EPSPs by a synapse from multiple axon terminals. Spatial summation is essentially
distributed computing, involving the input of relatively less hardworking axons to
achieve the same effect as one very hardworking axon trying to generate an action
potential.
There are several types of neural circuits. Diverging circuits involve an action
potential of one neuron traveling across a successively greater and greater number of
neurons. Converging circuits is the viceversa, with several neuronal action potentials
intersecting at one neuron. Reverberating circuits are made of two linear circuits, one
traveling in one direction across neurons and another traveling the other way from one
neuron at the end of the first circuit to the beginning of the first circuit so that the first
circuit is replicated due to the influence of the second circuit. Parallel afterdischarge
circuits are like diverging circuits that turn into converging circuits i.e. the action
potential diverges across several neurons then converges upon a neuron. The usefulness of
parallel afterdischarge circuits is that the action potential can exist even without the
originating neuron firing, as the inbetween neurons between divergence and convergence
can continue the action potential. An example with a simple parallel afterdischarge
circuit made of four neurons (so 2 inbetween) that fire at the same time will maintain the
action potential for twice the amount of time as if the inbetweens didn’t exist.