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butadiene, 1,3,5-hexatriene and allyl system, F.M.O. and PMO approach to cycloaddition and electrocyclic reactions: Generalisation of wood-ward Hoffmann rule, sigmatropic rearrangement-suprafacial and antrafacial shifts of H.Stereoselectivity in sigmatropic rearrangement, enantioselectinity in pericyclic reactions. Unit II : Conformational analysis Confirmation at cyclic systems: Confirmation of cyclohexane, mono and disubstituted cyclohexane, heterocyclic compounds, five and six membered heterocycles, stereoelectronic effects, fused bicyclic sptem, decalin, dodecalin, polyclin system, perhydrophenanthrene, bridged systems-conformation of sugars, steric strains due to unavoidable crowding, stereochemistry of the compounds containing nitrogen, sulphur and phosphorous. Unit III : Oxidation Introduction, different oxidation processes, hydrocarbons-alkenes, aromatic rings, saturated C-H group (activated and unactivated), alcohols, diols, aldehydes, ketones, amines, hydrazine and sulphides. Unit IV: Reduction Introduction, different reductive processes, hydrocarbons-alkanes, alkenes, alkynes and aromatic rings Carbonyl compounds- aldehydes, ketones, acids and their derivatives, epoxides, nitro, nitroso, azo and oxime groups, Preparation and properties and application of pd and Ti compounds as organometallic agents Reference books 1. Advance organic chemistry by Jerry March 2. Advance organic chemistry by Carey and Sundberg, 3. Advance organic chemistry by Francis A. carey
Unit I : Protection of groups Principle of protection of hydroxyl, amino, carbonyl, carboxylic acid with different reagents and their deprotection, synthetic equivalent groups, synthetic analysis and planning, control of stereochemistry. Unit II : Disconnection approach An introduction to synthesis, and synthetic equivalents, disconnection approach, functional group inter-conversions, the importance of the order of events in organic synthesis one group C-X and two group C-X disconnections, chemo-selectivity, reversal and polarity. Unit III : One group C-C disconnections Alcohols and carbonyl compounds, region-selectivity, alkene synthesis, use of acetylenes and aliphatic nitro compounds in organic synthesis. Unit IV: Ring synthesis Saturated heterocycles, synthesis of 3, 4, 5, and 6-membered rings, aromatic heterocycles in organic synthesis Reference books
1. Organic synthesis : the disconnection approach by stuart Warren (wiley student edition) 2. Organic chemistry- clayden, greeves, warren and wothers, (oxford press)
Water interaction among biomolecules in aqueous systems, buffering against pH changes, in biological systems, participation of water in biological reactions. Vitamins-classification, introduction, chemistry, absorption transport, mobilization and biochemical functions of Vitamins A, D, E, K, C, B, B2, B6, H and folic acid Unit II : Proteins,peptides and enzymes Proteins: properties and conventions of common amino acids, stereoisomerism in -amino acid, peptides: formation, compositions and sizes of protein separation, purification and characterization, sequencing of peptides, sangers method, edman degradation, outline of other methods, protein sequences and evolution. Oxygen binding proteins, haemoglobin and myoglobin in oxygen transport and storage. Enzymes: classification, nomenclature and extraction factors affecting catalytic activity and specificity in action, regulation of enzyme activity, enzyme inhibition, illustrative enzymatic reactions using chymotropsin, hexokinase, enolase and lysozyme
Unit III: Carbohydrates and nucleic acid Carbohydrates: classification and stereochemistry, biologically important hexose derivatives, nomenclature of disaccharides, structure and role of some homo and hetero polysaccharides, glucoconjugates : proteoglycans, glycoproteins and glycolipids Nucleic acid: compounds of nucleic acids, nomenclature of nucleotides, nucleosides, structure of DNA and structure of RNA Unit IV: Lipids Nomenclature, structure and physical properties of some naturally occurring fatty acids, triacelglycerol and waxes as sources of stored energy, insulation of water repellants, types of membrane lipids, introduction to glycerophospho lipids, galactolipids, sphingo lipids, phospholipids and sterols, bile acids. Reference books: 1. Principles of biochemistry Donald J.Voet, Judish G.Voet, charlotte w. pratt (John willey and sons) 2. Lehninger principles of biochemistry- David L.Nelson and Michael M.wx (Palgrave Macmillan / w.h. freeman company new york) 3. Biochemistry U.Satyanarayana Baro and allied P.Ltd., kolkata
Unit I : Drug design: Introduction, naming of organic medicinal compounds, literature of medicinal chemistry, development of new drugs, procedure followed in drug design, concept of lead compound and lead modification, pro drugs, soft drugs, phase I, II and III clinical trials, structure activity relationship, theories of drug activity : occupational theory, rate theory, induced fit theory, quantitative structure activity relationship, history and development of QSAR. Concept of drug receptors, elementary treatment of drug receptor interactions, physio chemical parameters lipophilicity, partition coefficient, electronic ionization constant, concept of 3-D QSAR. Unit II : Pharmacokinetic and pharmacodynamics Pharmacokinetics : introduction to drug absorption, distribution, metabolism, elimination. important pharmacokinetic parameters in defining drug deposition and in therapeutics, uses of pharmaceutics in drug development process Pharmacodynamics: Introduction, elementary treatment of enzyme stimulation, enzyme inhibition, drug metabolism, biotransformation, significance of drug metabolism in medicinal chemistry. Unit III : A. Dosage forms, Quality control and application of computers in chemistry Dosage forms, types of dosages, different roots of administration, quality control of drugs pharmacopias, modern methods of pharmaceutical analysis. B. Computer in chemistry Use of computer in chemistry and industry Important websites for data search chemistry Information about online journals for chemistry Unit IV:Medicine Overview, Medicinal use of nanomaterials-Drug delivery Protein and peptide delivery cancer, surgery, visualization, nanoparticle targeting Medical application of molecular nanotechnology-nanorobots, cell repair machines, nanonephrology.
References Books: 1. Burgers Medicinal Chemistry and Drug Discovery (5/e), 1997, Vol. 1, 2, 3, 4,5, Edited by ManFred E. Wolff (John Wiley & Sons, inc., New York). 2. Wilson and Gisvolds Text-book of Organic Medicinal and Pharmaceutical Chemistry (5/e, 1982) by Robert F. Doerge (J. B. Lippincott Company, Philadelphia/Toppan Co. Ltd., Tokyo). 3. Principles of Medicinal Chemistry, Vol. I & II (5/e), by S. S. Kadam, K. R. Mahadik, K. G. Bothra (Nirali Prakashan). 4. QSAR: quantitative structure-activity relationships in drug design by Jean-Luc Fauchre. ISBN:084515141X, 9780845151419 5. QSAR : Hansch analysis and related approaches By Hugo Kubinyi
(ii) (iii)
4. Physical chemistry- N.B.Singh, Shiva Saran Das, A.K.Singh (newage international publication),2009 5. Advanced physical chemistry J.N.Gurtu and A. Gurtu, pragati prakashan, 2008 6. Molecular spectroscopy C.N.Banwell 7. Introduction to Molecular spectroscopy : G.M. Barrow MacGraw Hill 8. Basic principles of spectroscopy R.Chang, McGraw Hill 9. Instrumental methods of analysis-Skoog & West 10. Molecular spectroscopy Gurdeep Raj 11. Instrumental methods of analysis- B.K.Sharma 12. Physical methods of chemistry R.S. Drago 13. Theory and applications of UV-spectroscopy- H.H.Jaffe and M.Orchin 14. N.B.Hannay : Solid state chemistry 15. A.R.West- solid state chemistry and its applications, John Wiley- 1987 16. Chemistry of solids L.V.Azaroff 17. Principles of solid state- H.V.Keer 18. Solids state chemistry- C.N.R.Rao 19. Fundamentals of photochemistry- K.K.Rohtagi, Mukherjee, Wiley-Eastern Ltd., 20. AGilbert-J.B.Baggott, Essentials of molecular photochemistry, Blackwell scientific, oxford, 1991 21. N.J.Turro-Modern molecular photochemistry, University science books, 1991 22. Crystallography and crystal chemistry- F.D. Bloss 23. Elements of x-ray diffraction, B.D. cullity, Addision Westey publication Co. London. 24. X-ray diffraction methods, E.W. Nuffield, John-wiley and sons, Inc,N.Y. 25. X-ray structure determination-A practical guide (G.H.Stout, L.H.Jensen, Mcmillan co. London) 26. Methods in X-ray crystallography- J.W.Jeffery, Acad. Press, London
38. Physical methods of chemistry R.S. Drago 18. Theory and applications of UV-spectroscopy- H.H.Jaffe and M.Orchin 19. N.B.Hannay : Solid state chemistry 20. A.R.West- solid state chemistry and its applications, John Wiley- 1987 21. Chemistry of solids L.V.Azaroff 22. Principles of solid state- H.V.Keer 23. Solids state chemistry- C.N.R.Rao 24. Fundamentals of photochemistry- K.K.Rohtagi, Mukherjee, Wiley-Eastern Ltd., 25. AGilbert-J.B.Baggott, Essentials of molecular photochemistry, Blackwell scientific, oxford, 1991 26. N.J.Turro-Modern molecular photochemistry, University science books, 1991 27. Crystallography and crystal chemistry- F.D. Bloss 28. Elements of x-ray diffraction, B.D. cullity, Addision Westey publication Co. London. 29. X-ray diffraction methods, E.W. Nuffield, John-wiley and sons, Inc,N.Y. 30. X-ray structure determination-A practical guide (G.H.Stout, L.H.Jensen, Mcmillan co. London) 31. Methods in X-ray crystallography- J.W.Jeffery, Acad. Press, London
Unit II :
Polymer chains, chain configuration of macro molecules, microstructures based on the chemical and geometrical structures, crystal structures of the polymers, crystalline melting point (tm) and glass transition temperature (tg), effect of chain flexibility and other steric factors, molecular weight, chain branching , cross linking etc. on tm and tg. Mechanical properties of polymers-tensile strength, impact strength, shear, stress stain viscosity, viscoelastic behaviour of polymers, mechanical models of viscoelastic behaviour, deformation behaviour of polymeric materials, stress-strain relationship for different types of polymers.
GUJARAT UNIVERSITY DESIGN AND STRUCTURE OF CHOICE BASED CREDIT SYSTEM OF M.Sc. CHEMISTRY
Depart ment Se me ster No. of hours per week Course Name Lec tur es Ot her s Pra ctic als Tot al Course credits
C
1 H E M I S T R y
CHE 401 CHE 402 CHE 403 CHE 404 CHE405PR CHE406PR CHE407 CHE408 CHE409 CHE410 CHE411 PR CHE412 PR
Inorganic Organic Physical Analytical Practical (Inorganic + Organic) Practical (Physical + Analytical) Total Inorganic Organic Physical Analytical Practical (Inorganic + Organic) Practical (Physical + Analytical)
3 3 3 3 --12 3 3 3 3 --12 3 3 3
1 1 1 1 --4 1 1 1 1 --4 1 1 1
4 4 4 4 4 4 24 4 4 4 4 4 4 24 4 4 4
4 4 4 4 4 4 24 4 4 4 4 4 4 24 4 4 4
Inorganic 3
CHE 502 EI CHE 503 EI
3 -12 3 3 3
1 -4 1 1 1
-12 12 ----
4 8 24 4 4 4
4 8 24 4 4 4
Organic
3 --
1 -4
-12 12
4 8 24
4 8 24
Total
12
Physical CHE 501 EP CHE 502 EP CHE 503 EP CHE 504 EI CHE 504 EO CHE 504 EP CHE 504 EA CHE 505 EP PR CHE 501 EA CHE 502 EA CHE 503 EA CHE 504 EI CHE 504 EO CHE 504 EP CHE 504 EA CHE 505 EA PR
CHE 507 EI CHE 508 EI CHE 509 EI
Advanced Physical Chemistry Selected topics in Physical Chemistry Polymer Chemistry Choice Based Electives for all Specializations Supramolecular Chemistry Bio organic Chemistry Catalysis-1 Modern Separation techniques Practicals
3 3 3
1 1 1
----
4 4 4
4 4 4
3 --
1 -4 1 1 1
-12 12 ----
4 8 24 4 4 4
4 8 24 4 4 4
Total
Industrial Analytical Qualitative Optical Spectroscopic Methods Electro analytical technique Choice Based Electives for all Specializations Supramolecular Chemistry Bio organic Chemistry Catalysis-1 Modern Separation techniques Practicals
12 3 3 3
Analytical
--
-Total 12 3 3 3
-4 1 1 1
12 12 ----
8 24 4 4 4
8 24 4 4 4
Inorganic
Advanced Inorganic Chemistry Selected topics in Inorganic Chemistry Advanced industrial inorganic chemistry Choice Based Electives for all Specializations Intellectual property rightsBasics Selected topics in Medicinal Chemistry Catalysis-2 Environmental chemistry dissertation/industrial training
--
-12
-4
12 12
8 24
8 24
Total
Organic
CHE 507 EO CHE 508 EO CHE 509 EO
Advanced organic chemistry Advanced organic Synthesis Industrial Chemistry Choice Based Electives for all Specializations Intellectual property rightsBasics Selected topics in Medicinal Chemistry Catalysis-2 Environmental chemistry dissertation/industrial training
3 3 3
1 1 1
----
4 4 4
4 4 4
--
-12
Physical
-4 1 1 1 1 -4 1 1 1
12 12 ----12 12 ----
8 24 4 4 4 4 8 24 4 4 4
8 24 4 4 4 4 8 24 4 4 4
Total CHE 507 EP CHE 508 EP CHE 509 EP CHE(P) 510 CHE 511 EP PR
Advanced Physical Chemistry Selected topics in Physical Chemistry Polymer chemistry-2 Catalysis-2 dissertation/industrial training
3 3 3 3 -12 3 3 3
Analytical
--
-12
-4
12 12
8 24
8 24
Total
References
1. 2. 3. 4. 5. 6. 7. 8. 9. Handbook of Instrumental Techniques for Analytical Chemistry, Frank Settle, published by Prentice Hall PTR, New Jersey, 1997. Applied Infrared Spectroscopy, Smith A L, published by Wiley, New York, 1979. Instrumental Methods of Analysis, Willard H H, 7th edition, Belmont, CA : Wadsworth, 1987. Raman Spectroscopy, Long D A, McGraw Hill, New York, 1977. Laboratory Raman Spectroscopy, Strommen D P, Nakamoto N, Wiley, New York, 1984. Spectrometric Identification of Organic Compounds, Silverstein R M, Bassler G C, Morrill T C, 5th edition, Wiley, New York, 1991. Introduction to NMR Spectroscopy, Abraham R J, Fisher J, Loftus P, Wiley, New York, 1988. Elements of X Ray Crystallography, Azaroff L V, McGraw Hill, New York, 1968. X Ray Structure Determination : A Practical Guide, Stout G H, Jensen L H, 2nd edition, Wiley, New York, 1989.
12 13 14 15
Modern Practice of Gas Chromatography by Robert L. Grob and Eugene F. Barry, 3rd edition, Wiley-Interscience, 1995. Basic Gas Chromatography by Harold M. McNair, James M. Miller, John Wiley and Sons, 2008. Analytical gas Chromatography by Walter Jennings, Eric Mittlefehldt and Philip Stremple, second edition, Elsevier Science, 1997. Modern HPLC for practicing scientists by Michael W. Dong, Wiley Interscience, 2006.
SEMESTER -3 (Analytical Chemistry -Practicals) CHE(A)505 & 506 PR Industrial Analytical Chemistry-Practicals Semester III Practical (Core subject)
1. pKa determination of drugs by spectrophotometry 2. Characterisation of drugs substance by IR. 3. Flame Photometry and Atomic Absorption Spectrophotometry. 4. Simultaneous determination of metal ions by spectrophotometry. 5. Solvent extraction of transition metal ions 6. Ion-exchange separation of cations and anions 7. Fluorimetric determination of vitamins and drugs 8. Method validation for linearity, accuracy and precision. 9. Characterization of drug substances by IR Spectroscopy. 10. High performance liquid chromatography. 11. Gas chromatography.
References
1. 2. 3. 4. 5. 6. 7. 8. Handbook of Instrumental Techniques for Analytical Chemistry, Frank Settle, published by Prentice Hall PTR, New Jersey, 1997. Specrochemical Analysis by Atomic Absorption and Emission, Lajunen L H J, Cambridge, UK : The Royal Society of Chemistry, 1992. Advances in Atomic Spectroscopy, Sneddon J, CT : JAI Press, Greenwich, 1992. CRC Handbook of Inductively Coupled Plasma Atomic Emission Spectrometry, Varma A, FL : CRC Press, Boca Raton, 1991. Multielement Detection Systems for Spectrochemical Analysis, Busch K W, Busch M A, Wiley, New York, 1990. Principles and Practice of X Ray Spectrometric Analysis, 2nd edition, Bertin, Eugene, Plenum Press, New York, 1975. An Introduction to X Ray Spectrometry, Jenkins, Ron, Heyden & Sons, London, 1974. Principles of Quantitative X Ray Fluorescence, Tertian R, Claisse F, Heyden, London, 1982.
UNIT-2
THE ATMOSPHERE
Composition of the atmosphere, Common air pollutants and their sources, Gases, vapours and particles, Air pollution and health, Sampling of air borne solids, Examination of airborne solids, Direct instrumental methods for gaseous pollutants, Sampling of gases and the atmosphere, Gas chromatography, Some chemical methods for determining trace gases, Some case studies of air pollution.
UNIT-3
THE HYDROSPHERE
The hydrological cycle and pollution, The oxygen balance in natural waters, Observations on sampling, Storage of samples and prevention of contamination, The analysis of water, Selected analytical methods for water quality control, pH measurement the glass electrode, Conductivity, Dissolved oxygen (DO), Biochemical oxygen demand (BOD), Chemical oxygen demand (COD), Methods for the determination of inorganic nitrogen, Determination of phosphate, Automation of colorimetric procedures, The determination of chloride by titrimetry (visual), Ion-selective electrodes, Ion chromatography, The determination of heavy metals, The importance of chemical species speciation, Trace organics in water total organic carbon (TOC), Determination of some individual compounds or groups of compounds in polluted water, Gas chromatography / mass spectrometry (GC / MS), The EPA survey procedure : priority pollutants.
UNIT-4
Introduction, The need for chemical analysis of solids and rocks, Available elements, Particles size distribution in solids, Soil analysis versus visual symptoms shown by plants, Sampling problems with rocks and soils, Subsampling, Dissolution for total element analysis, Some selected chemical methods in soil analysis, Flame atomic absorption spectroscopy, Flame emission spectroscopy, Other emission techniques, Identification of minerals, The nature of the biosphere, The need for analysis of zoological specimens, The merits of treating the biosphere as a whole, Sampling problems, Sample preparation problems, Sample dissolution, Analysis of plant tissues for N, P, K, Ca and Mg, Boron in plant tissue, Cobalt in plant tissue, Sulphur in plant tissue, Simultaneous multi-element analysis, The role of trace element in living systems, Trace element determinations on very small samples, Cold vapour and hydride generation systems in AAS.
REFERENCES
1) 2) 3) 4) 5) 6) 7) 8) Lain L. Marr, Malcolm S. Cresser, Environmental Chemical Analysis, Published by International Textbook Company, New York. Laitinen, H. A. and Harris, W. E., Chemical Analysis, 2dn Edition, McGraw-Hill, New York. Katz, M., Methods of Air Sampling and Analysis, 2ed Edition, American Public Health Association, Washington, DC. Israel, H. and Israel, G.W., Trace Elements in the Atmosphere. Ann Arbor, Michigan. Z. Marczenko, Spectrophotometric Determination of the Elements, Ellis Horwood, Chichester. Wilson, A.L., The Chemical Analysis of Water : General Principles and Techniques, The Society for Analytical Chemistry, London. Black, C.A., Methods of Soil Analysis, American Society of Agronomy, Madison, Wisconsin. Brooks, R.R., Geobotany and Biogeochemistry in Mineral Exploration, Harper and Row, New York.
12. 13.
SEMESTER -3 (Inorganic Chemistry) Inorganic Pharmaceutical & Medicinal Chemistry CHE(I) 503
Unit 1. (a) Pharmacopocia and Monography Electrolytes, major physiological ions, physiological acid-base balance, acid base imbalance, electrolytes used for replacement therapy, electrolytes used in combination therapy. (b) Gastro-intestinal tract agents Acidifying agents, gastric antacids, protective and adsorbents, saline cathartics Antioxidants and buffers Unit 2 (a) Expectorants and Emetics- symptoms of respiratory disease, expectorants, antitussive and emetics. (b) Topical agents Protective, astringents and antimicrobials Units 3 (a) Trace elements- copper, iron, iodine, manganese, zinc, their compounds and their relevance. (b) Metals in medicine : Biomedical significance. Role of metal ions in drug design Platinum antitumor agents- discovery and development, synthesis. Unit 4 (a) Vanadium complexes oxovanadium(IV) complexes for diabetes treatment (b) Medicinal applications of metal complexes of N-Heterocyclic carbenes (NHC)NHC precursors and metal complexes pyridine based NHC precursors and metal complexes, NHC Rhodium complexes.
References : 1. A handbook of Inorganic Pharmaceutical Chemistry, Dr. K. G. Bothara, Nirali Prakashan. 2. Medicinal Inorganic Chemistry, American Chemical Society, Washington, DC 3. Medicinal Inorganic Chemistry : Orvig, C, Abrams, M. J. Eds.; Chemical Reviews Vol. 99, No.9, American Chemical Society, Washington, D.C. 1999. 4. Metallopharmaceuticals I & II, Clarke, M. J., Sadler, P., Eds., Springer, Verlag, New York, Inc., 1999. 5. Uses of Inorganic Chemistry in Medicine, Farrell, N., Ed., Springer-Verlag, New York, Inc.1999.
UNIT IV Chemistry of Lanthanides and Actinides Separations, spectral and magnetic properties, organometallic chemistry of lanthanides and actinides. Transuranium elements.
References
1. 2. 3. 4. 5. 7. 8. 9. 10. Structural methods in inorganic chemistry, E.A.V.Ebsworth, D.W.H. Rankin and S.Cardock Spectroscopic Identification of Organic Compounds R.M.Silverstein, G.C.Bassler and Morril. Physical Methods in Inorganic Chemistry R.S.Drago. Applications of absorption spectroscopy of organic compounds J.Dyer. Electron Spin Resonance Elementary Theory and Practical Applications Wertz and Bolton Green, M. L. H. Organometallic Compounds Chapman & Hall: U.K. (1968). Coates, G. E., Green, M. L. H. & Powell, P. Principles of Organometallic Chemistry Chapman and Hall: U.K. (1988). Organometallic Chemistry a Unified Approach by R.C.Mehrotra and A.Singh, Organometallic Chemistry of Transition Metals by Robert H.Crabtree.
CHE(I) 509
Advanced Industrial Inorganic Chemistry Unit 1 - Nanomaterials in Chemistry Introduction to nanomaterials and nanochemistry, classification of nanomaterials general methods of preparation and applications. Chemical and catalytic aspects of nanocrystals nanomaterials in catalysis, as adsorbents, as new chemical reagents. Unit 2 Smart materials Ceramics, alloys, gels and polymers. Piezoelectric materials, electrostrictive and magnetostrictive materials, rheological, thermoresponve, pH sensitive halochromic materials, electrochromic materials and smart gels. Unit 3 Chemical and Biofertilizers Chemical fertilizers, applications, adverse effects, Advantage of biofertilizers. Types of Mineral Fertilizers : Nitrogenous fertilizers, phosphatic and potassic fertilizers, NPK grades. Nitrogen biofertilizer : Rhizobium (symbiotic) Azetobactor (non symbiotic) Phosphorus biofertilizer : P.S. B. phosphate solubilizing bacteria..
Unit 4 Environmental Chemistry Types of water pollutants : organic, inorganic, radionucluds and their determination COD, BOD and industrial waste water treatment for solids, metals, dissolved organics and inorganics. Air pollutants CO,SOx, NOx, CFC, hydrocarbon and their monitoring. Disposal of hazardous wastes. References:
1. Nanoparticles, buildings blocks of nanotechnology, Rotello V. Kluwer Acad / ptenum publication, N.Y.2004 2. Nanoscale materials in chemistry- ed. By Klabunde K.J.John-wiley, N.Y. 2001 3. The chemistry of nanomaterials : Synthesis, properties and applications ed. By. C.N.R.Rao, A. Miiller and A.K.Cheetham, wiley-VCH ,2004 4. Nanotechnology, Richard Booker, Earl Boysen, Wiley 5. Environmental Chemistry, Akde,Wiley Eastern Ltd. 6. Environmental Chemistry, B. K. Sharma, H. Kaur, Goel Publishing House, Meerut. 7. Environmental Chemistry, B. K. Sharma, Goel Publishing House, Meerut
Unit-4 Prior art Search-1 Prior art Search-2 Requirement of IPRs in Pharmaceutical & Chemical industries and career development in IPR References: 1. Intellectual Property Rights, Anita Rao & Bhanoji Ra 2.. The Law Of Intellectual Property Rights, Shiv Sahai Singho 3. Intellectual Property Rights in the WTO and Developing Countries, Jayashree Watal
Unit II : Psychoactive drugs CNS depressant: A. General and local anaesthetics B. Sedative and hypnotics Antipsychotic drugs A. Antidepressant B. Neuroleptics Synthesis of the following Thiopental, amobarbital, diazepam, chlorozepan, alprazolam, glutethimide, nikethamide, procaine, lidocaine and dibucaine, Ibuprofin, meclofenate sodium, novalgin, pethidine Unit III: Antimalarial and Antituberculosis drugs Antimalarials: Modern chemotherapy of malaria, 4-amino and 8-amino quinolins, 9-amino acridine. Synthesis of mefloquines, chloroquine, primaquine and daraprim Mode of action of antimalarial agents SAR of antimalarial agents Anti tuberculosis: Synthesis of only the following drugs: Isoniazid (INH), Ethionamide, Ethambutol, DDS (Dapsone) Unit IV :Cardiovascular, diuretics and hypoglycemic agents Synthesis of amyl nitrate, diltiazim, atenolol, methyl dopa, tolbutamide, chloropropamide, glibenclamide, acetazolamide, chlorothiazide, furosemic and ethacrycnic acid Reference books: 1. Burgers medicinal chemistry and drug design (5/e) 1997, vol 1 to 5 edited by Manfred E.Woltt (John wiley and sons Mc. New york) 2. Principles of medicinal chemistry by William A. Foye (ied), lea and febiys (Philadelphia) 3. Principles of medicinal chemistry vol I & II (5/e) F.S.kadam, K.R. Mahadic ad K.G.Bohra (Nirali publication) 4. Medicinal chemistry by ashutosh kar 5. The organic chemistry of drug synthesis vol I, II and III (1980) ed by D. lednicer and L.A. mitscher (Johyn wiley and sons, New york) 6. Wilson and Gisvold text book of organic medicinal and pharmaceutical chemistry (5/e,1982) by Robert Doerge (J.B. lippincoff company, phaladophia/ Toppan co.Ltd, Tokyo) 7. Topics in medicinal chemistry vol I & II by rabinowitz Myerson (interscience 1968) 8. The pharmaceutical basis of theraperutics by Geoman and Gilman (Mcmillan co.)
Unit III: C13 NMR and Mass spectrometry C13 NMR: elementary ideas, instrumental problems ,chemical shift features of hydrocarbons, effect of substituent on chemical shifts olefinic, acetylenic, aromatic and carbonyl carbons, effects of coupling Mass spectrometry: theory, instrumentation, modes of ionization, types of detectors, modes of fragmentation. Different types of ions, molecular ions, isotopic peaks, factors controlling fragmentation, hyphenated mass spectroscopy techniques. Unit IV: Structural elucidation of drug molecules based on joint application of UV,IR, PMR, CMR and mass spectroscopy. Reference books: 1. Spectroscopic methods in organic chemistry, D.H.Williams and Tan fleming 2. Spectrometric identification of organic compounds, T.C.Morril R.M.Silverstein and G.Bassler, 6th edition, John Wiley and sons 3. Introduction to spectroscopy, D.L.Pavia, G.M.Lampman and G.S.Kriz, 3rd edn, Harcourt college publishers. 4. Organic spectroscopy by W.Kemp 5. Organic spectroscopy by P.S.Kalsi
1. Organic synthesis : the disconnection approach by stuart Warren (wiley student edition) 2. Organic chemistry- clayden, greeves, warren and wothers, (oxford press)
Unit III: Carbohydrates and nucleic acid Carbohydrates: classification and stereochemistry, biologically important hexose derivatives, nomenclature of disaccharides, structure and role of some homo and hetero polysaccharides, glucoconjugates : proteoglycans, glycoproteins and glycolipids Nucleic acid: compounds of nucleic acids, nomenclature of nucleotides, nucleosides, structure of DNA and structure of RNA Unit IV: Lipids Nomenclature, structure and physical properties of some naturally occurring fatty acids, triacelglycerol and waxes as sources of stored energy, insulation of water repellants, types of membrane lipids, introduction to glycerophospho lipids, galactolipids, sphingo lipids, phospholipids and sterols, bile acids. Reference books: 1. Principles of biochemistry Donald J.Voet, Judish G.Voet, charlotte w. pratt (John willey and sons) 2. Lehninger principles of biochemistry- David L.Nelson and Michael M.wx (Palgrave Macmillan / w.h. freeman company new york) 3. Biochemistry U.Satyanarayana Baro and allied P.Ltd., kolkata
References Books: 1. Burgers Medicinal Chemistry and Drug Discovery (5/e), 1997, Vol. 1, 2, 3, 4,5, Edited by ManFred E. Wolff (John Wiley & Sons, inc., New York). 2. Wilson and Gisvolds Text-book of Organic Medicinal and Pharmaceutical Chemistry (5/e, 1982) by Robert F. Doerge (J. B. Lippincott Company, Philadelphia/Toppan Co. Ltd., Tokyo). 3. Principles of Medicinal Chemistry, Vol. I & II (5/e), by S. S. Kadam, K. R. Mahadik, K. G. Bothra (Nirali Prakashan). 4. QSAR: quantitative structure-activity relationships in drug design by Jean-Luc Fauchre. ISBN:084515141X, 9780845151419 5. QSAR : Hansch analysis and related approaches By Hugo Kubinyi