Академический Документы
Профессиональный Документы
Культура Документы
Qian Wang
Department of Chemistry and Biochemistry Nanocenter University of South Carolina
Nanomedicine, 2006, 137 Chem. Commun. 2007, 1453 Optics Commun. 2005, 366 TL, 2005, 1691; JACS, 2007, ASAP Bioconj. Chem, 2007, 852 Bioorg. Chem. 2008, in print See also: ACIE, 2002, 459; Chem. & Biol. 2002, 805 & 813; Biomacromolecules, 2003, 472; Bioconjugate Chem. 2003, 38; Biomacromolecules, 38 Chembiochem, 2003, 1348.
Chem. Commun. 2006, 3019; ACIE, 2005, 2420; Science, 2006, 312, 1631; Nature 2005, 434, 55; Micro & Nano Lett., 2006, 1; Langmuir, 2007, 6719; NanoBiotechnoloty, 2007, 31; Langmuir, 2007, 11157; Nano Lett, 2007, 7, 3729
CPMV
TYMV
mrsec.wisc.edu
Availability Stability and safety Well-defined structures Identical in size and shape Genetically programmable Robust chemistry
absorbance (a.u.)
-0.01 0 5 10 15 20 25 30
volume (mL)
Extraction
Plant homogenate 2 sq ft
Organic solvent 1-2 g particle (>97% pure) < $200 per gram
MS2/TMV: Francis
RCNMV: Franzen
TYMV: Wang
Bionanoparticles
targeting units
Biocomposite Materials
Qian Wang
Chem. Commun. (2006) 3019 NanoBiotechnology (2007) in print Angew. Chem. Int. Ed. (2005) 2420 Science (2006) 312, 1631 Nature (2005) 434, 55 Micro & Nano Lett. (2006) 1, 1
Cell Culture: Fibroblast cells Bone Marrow Stems cells Cardiac Myocytes
Conventional bioconjugation chemistry Genetic Modification Post-functionalization: Click Reaction In situ polymerization Surface coating via non-covalent interactions
Glu/Asp Virus
Arg
R1
NH NH2 x
NCS
H N S
H N R
Lys
AE
H N R O
Cys
HO y
X R R2 N (F) Cl N R1 O N
H N Y R R2 H N N N N R1 N CH R Reduction H N CH2 R
Tyr
NH R N R N R
O S O
AE =
S R O S O
N O O
H N
H 3C
CH3 N CH3
Y = -CO-, -SO2-
Finn and Johnson, Angew. Chem. Int. Ed. 2002, 41, 459; Andrew Lee: Nanomedicine, 2006, 137
OH HO AcHN O N O
OH O O N H H N O OH
O (H2N)60 S O N Tn-Antigen 60
+
(H2N)60 (SH)60
Tn-Antigen Cys-CPMV
VBCCys
O
VEFCys
(CH2CH2O)n CH3
DNAs
(CH2CH2O)n
Drugs
Polymer
HOOC
N
N
O C N H
COOH
Proteins
HOOC
COOH
MRI Ligands
O
O
NH
HN
NH
OH
HOOH
S
O
Fluorescent Dyes
O O
O NHAc
O
O
biotin
OH
Carbohydrates
JACS 2007, 7799; Nanomedicine, 2006, 137; Chem. Commun. 2007, 1453; Optics Commun. 2005, 366; Tetrahedron Lett. 2005, 1691; Bioconj. Chem. 2007, 853; Nanobiotechnology, 2007, accepted. See also: Angew. Chem. Int. Ed. 2002, 41, 459; Chem. & Biol. 2002, 9, 805 & 813; Biomacromolecules, 2003, 4, 472; Bioconjugate Chem. 2003, 14, 38; Nano Lett. 2003, 3, 883; Chembiochem, 2003, 4, 1348. 38
Mike Bruckman
Organic solvents
interface
BNPs
(A)
shaking crosslinking
organic polymer
(B)
Water Oil
Water Oil
crosslinking
40m
P4VP
Tao Li
1D assembly
surface recognition
Po l ym eriz atio n
2D assembly
Zhongwei Niu
Zhongwei
Zhongwei
Conductive Nanowires
Wang Group: Dr. Zhongwei Niu Dr. Cline le Droumaguet Dr. Jianhua ROng Michael Bruckman Siqi Li L. Andrew Lee Gagandeep Kaur Tao Li Kai Li Jerry Oxsher Laying, Eve, Sharmi, Lily Fang Xie (Ph.D.) Hannah Barnhill (Ph.D.) Brandon Cash (M.S.) Su Long (M.S.) Swat Kabisatpathy Dr. Seok-Joon Lee Dr. K. Sivakumar Dr. Srinivas Chitaboina Dr. Venkata S. Kotakadi Dr. Qingbing Zeng Dr. Kris Varazo Daiki Kyotani Lisa Alexander Preston Thompson Other Undergraduate Students
Acknowledgments
BNP Assembly: Prof. Tom Russell Yao Lin Dr. Alex Bker Jinbo He Dr. Andreas Fery Prof. Anna Balazs Prof. T. Dinsmore Dr. P. Thiyagarajan Dr. Byeongdu Lee Dr. Lin Yang Prof. Cathy Murphy Prof. Ken Shimizu Prof. J. Lavigne Prof. H. zur Loye Cell Study Prof. Yu-Li Wang Prof. J. Potts Prof. Z. Su Prof. S. Kistler Prof. E. Jabbari Protein Binding Study Prof. David Tirrell Prof. Lukasz Lebioda Virus Propagation: Prof. Theo Dreher Prof. Rick Nelson Prof. Vicki Vance Click Related Reaction: Prof. K. Barry Sharpless Prof. M.G. Finn Prof. Valery Fokin Prof. Greg Tew Prof. Todd Emrick Prof. Dan Reger Cyanine Dye Synthesis: Prof. He Tian Wenhai Zhan $$$ Alfred Sloan Foundation NSF-CAREER NSF-NER/NSF-DMR DOD-MURI / DOD-DURIP ARO-BCRP W. M. Keck Foundation USC Research Foundation USC NanoCenter SC EPSCoR Office & SCCC