Biomaterials: Design and Applications Biomaterials: Design and Applications

S. Kanagaraj
kanagaraj@iitg.ernet.in
http://www.iitg.ernet.in/kanagaraj
27-12-2011
Scope and objecties
Studies on nonviable materials used in a
medical device intended to interact with
biological systems where the materials are
expected to perform with an appropriate host
response in a specific application response in a specific application
It is expected to give good exposure
pertaining to the field of biomaterials and
have broad understanding biomaterials
research.
It coers..
Introduction
Classes of materials used in medicine:
metals, polymers, FRPs, fabrics, nanocomposites, bioresorbable and bioerodable
materials, ceramics, glasses
Host reactions to biomaterials:
biocompatibility, implant associated infection
Testing of biomaterials: Testing of biomaterials:
in vitro assessment, in vivo assessment, blood materials interactions
Design of materials for biomedical application:
Cardiovascular, dental implants, orthopedic application, skin, ophthalmologic
applications, wound healing, sutures, biomedical and biosensors
Implantation techniques for soft tissue and hard tissue replacements
Problems and possible solutions in implant fixation
Failure analysis of medical devices and implants.
1ext and Reerence books
Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons. Biomaterials Science:
An Introduction to Materials in Medicine, Academic Press, 2004, USA
J.B. Park and J.D. Bronzino. Biomaterials: Principles and Applications. CRC Press. 2002. ISBN:
0849314917
Reference Books
T. M. Wright, and S. B. Goodman. Implant Wear in Total Joint Replacement: Clinical and Biologic
Issues, Material and Design Considerations. American Academy of Orthopaedic Surgeons, 2001.
T.S. Hin (Ed.) Engineering Materials for Biomedical Applications. World Scientific. 2004. ISBN T.S. Hin (Ed.) Engineering Materials for Biomedical Applications. World Scientific. 2004. ISBN
981-256-061-0
B. Rolando (Ed.) Integrated Biomaterials Science. Springer. 2002. ISBN: 0-306-46678-3
D.Shi, Introduction to Biomaterials, Tsinghua University press, 2005
DL. Wise, DJ. Trantolo, K Lewandrowski, JD. Gresser, M Cattaneo, MJ Yaszemski, Biomaterials
Engineering and Devices , Humana Press, New Jercy, 2000
JY Wong and JD Bronzion, Biomaterials, CRC press, 2007
R Barbucci , Integrated Biomaterials Science, Kluwer Academic Publishers, New York, 2002
G S Sawhney, Fundamentals of Biomedical Engineering, New Age International private Limited,
New Delhi, 2007
Peter A. Revell, Joint replacement technology, CRC Press New York 2008
Mark distribution
Mini project/Quiz/Assignments 20%
Mid semester- 30%
End semester-50%
List o Journals
American Society of Artificial Internal Organs Transactions
Annual reviews of Biomedical Engineering
Artificial Organs (Raven Press)
Bio-medical Materials and Engineering (ed. T. Yokobori, Pergamon Press)
Biomaterials (including Clinical Materials) (Elsevier)
Biomaterials, Artificial Cells and Artificial Organs - (Ed., T.M.S. Chang)
Biomaterials Forum (Society For Biomaterials)
Biomaterials: Processing, Testing and Manufacturing Technology (Butterworth)
Biomedical Materials (Elsevier)
Dental Materials
Drug Delivery Technology
International Journal of Artificial Organs (Wichtig Editore) International Journal of Artificial Organs (Wichtig Editore)
Journal of Bioactive and Compatible Polymers (Technomics)
Journal of Biomaterials Applications (Technomics)
Journal of Biomaterials Science: Polymer Edition (VSP Publishers)
Journal of Biomedical Materials Research (Wiley- Official Publication of the Society for
Biomaterials)
Journal of Biomedical Materials Research: Applied Biomaterials (Wiley)
Medical Device and Diagnostics Industry (Canon Publications)
Medical Device Research Report (AAMI)
Medical Device Technology (Astor Publishing Corporation)
Medical Plastics and Biomaterials (Canon Communications, Inc.)
Nanobiotechnology
Trends in Biomaterials & Artificial Organs (Society For Biomaterials And Artificial Organs
India)
Interrelation between Lngineering and medicine
Biologist
Engineer
Physician
Biomaterials
Disciplines inoled in
biomaterials science and
the path rom a need to a
manuactured medical
deice.
Need o studying Biomaterials
To select a material for a given use based on
considerations of cost and performance.
To understand the limits of materials and the
change of their properties with use. change of their properties with use.
To be able to create a new material that will have
desirable properties.
To be able to use the material for different
application.
1he Biomaterials and lealthcare Market in USA
USA market for biomaterials (2000) $ 9000 million
Cardiovascular devices (2002) $ 6000 million
Orthopedic musculoskeletal surgery $ 4700 million
Wound care $ 3700 million
In vitro diagnosis $ 10 000 million
Number of devices
Intraocular lenses (2003) 2, 500, 000
Contact lenses (2000) 30, 000, 000
Vascular grafts 300,000
Heart valves 100,000
Pacemakers 400,000
Breast prosthesis 250, 000
Catheters 200, 000, 000
Heat-lungs 300, 000
Hip prosthesis (2002) 250, 000
Knee prosthesis (2002) 250, 000
Dental prosthesis (2000) 910, 000
Dierent medical deices used
Ramakrishna et al. (2001), Composite Science and
Technology, 61, 1189
Various applications of different
polymer composite biomaterials
Shoulder joints
Spine disc
Elbow
Most requently used
replaceable joints
Hip joints
Knee joints
Finger joints
Ankle
\hat are the dierent types o joints
Some applications o synthetic materials and modiied natural
materials in medicine