INDRANI RAJAN

832.326.8617 iranjanusa@gmail.com

Scientific Director
Conscientious, accomplished, innovative and detail-oriented scientist-Provide astute, well-founded research grounded in meta-analysis of data, strong logic and multimodal thinking. Effectively translate complex concepts for execution, collaborating with others to transfer skills and advance a wide range of biologic, medical and technical disciplines. Communicate in a succinct, unique, and coherent manner to inspire confidence in all parties served and build consensus. Broad industry knowledge and capability in combining a wide range of scientific skills from genetics, molecular biology to electrophysiology within biotechnology, pharmaceutical and contract research business sectors. Specialized capabilities include:

Contract Research Business Development In Vivo Pharmacology Rodent Pain Models Molecular Neuroscience and Genetics Biochemistry/Biotechnology Peer Reviewed Documentation Project Management Small Rodent Surgery Gene Therapy Slice Electrophysiology DNA/RNA Isolation and Manipulation Transgenic mouse models Gene Expression and Analysis Writing Patents and Manuscripts Protein Sequence Analysis Embryonic Stem Cell Technology Cell Culture assays Tactical Partnerships Teaching Team Facilitation Drug Discovery and Development Research Rodent Behavior

PROFESSIONAL EXPERIENCE
ALGOS PRECLINICAL SERVICES, Roseville, MN 55113 2011-2012 A 25-person, contract research company specializing in animal pain models and in vivo efficacy pharmacology. Pain models included bone cancer, bone fracture, arthritic and rheumatoid pain, inflammatory, fibromyalgia, neuropathic and diabetic models. Director Biology (2011-2012): Managed a team of 12 researchers focused on pain research and behavioral pharmacology. I directed and managed high throughput screening of client compounds for efficacy in behavioral endpoints in various pain models. In this position I had extensive client interactions and management of client deliverables and expectations along with team management. Hired 6 researchers to grow the team to 12 members in 3 months. Facilitated progress of 3 new pain models Put in place process for quality standards for assays with device calibrations and testing standards. Managed over 60 client and internal studies. Concurrently managed the move of the research team to a new facility beginning of 2012 and ran complete validation studies for the 2012 catalogue.

LEXICON PHARMACEUTICALS, INCORPORATED, The Woodlands, Texas 2000 2009 A 500-person, biopharmaceutical firm specializing in drug discovery from human genome functional proteomics analysis. Neuroscience portfolio included, affective and neurodegenerative disorders, cognitive enhancement, sensory recovery and pain programs. Principal Scientist (2005 2009): Led all initiatives and contributed directly to projects within neuroanatomy and neurophysiology lab, reporting directly to the V. P. of neuroscience and supervising 2 experimental scientists. Engaged in gene expression as correlating to behavior. Progressing projects and obtaining robust results expeditiously, using various techniques including single cell RT-PCR, delicate

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iranjanusa@gmail.com

rodent microsurgery and electrophysiology. Designed experiments, addressed ongoing questions, and gathered data from genetics to biomarker analysis for joint project meetings in which scientific collaboration ensued to further drug development with BMS. Researched in depth the genotype-phenotype correlation of over 150 novel genes. Successfully executed in situ hybridization or LacZ expression profile of 60 novel genes. Performed LTP analysis of 3 novel gene knockout mouse lines and synaptic neurotransmission analysis of 5 gene knockout mouse lines. Recorded auditory brainstem response of 15 gene knockout lines. Performed microsurgery of the middle ear for gene therapy rescue of a novel gene. Conducted successful translational biomarker assay development for 4 drug candidates. Advanced troubleshooting of a mouse neuropathic pain model. Pioneered patent applications for publication and first-in-man compounds for Lexicon clinical trials Furthered a major project, executing single-cell RT-PCR to identify crucial cell types of the striatum. Contributed 3 published papers, progressed 3 more papers and multiple patent applications, earning prestigious promotion as one of few principal scientists. Senior Scientist (2000 2005): Advanced sole revenue generating department, supervised 4 researchers and oversaw up to 40 projects simultaneously. Conducted quality control checks on strategy and processes of 6 other teams led by Ph.D scientists. Fulfilled goal of creating targeting vector needed to generate gene knockout mouse lines. Completed and delivered to alliance partners over 125 projects with knockout mice, within tight timelines, each $70K to $100K, totaling over $10M. Analyzed and reported phenotype findings in 50 projects, to drug discovery research committee. UNIVERSITY OF WASHINGTON, Seattle, Washington A University with over 1000 employees. 1998 2000

Senior Postdoctoral Fellow: Participated in a new field of study and generated a formal publication based on 2 years of careful research. COLD SPRING HARBOR LABORATORY, Cold Spring Harbor, New York 1996 1998 A prestigious, 1000-person private research firm and a home to 7 Nobel laureates. Postdoctoral Fellow: Participated in basic scientific research and input into various publications. Produced 5 peer reviewed research publications in 2 years.

EDUCATION/TRAINING Bachelor of Science, Chemistry, Botany, Zoology Bangalore University, Bangalore, India Master of Science, Zoology Bangalore University, Bangalore, India (University 5th Rank holder) Ph.D., Biological Sciences University of Iowa, Iowa City, Iowa ADDITIONAL COURSES/TRAINING/SELF-DEVELOPMENT Bachelor of Education, Teaching Certification Madurai Kamaraj University, Madurai, India

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iranjanusa@gmail.com

PROFESSIONAL/BUSINESS MEMBERSHIPS Society for Neuroscience, AAAS, LinkedIn FOREIGN LANGUAGES Hindi, Tamil SPECIAL SKILLS

A Detailed list of Technical and Computer Skills, Awards, Fellowships, Distinctions, Publications, Patents, Teaching Experience and Peer-Reviewed Research available upon request

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