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glycine Thymidine synthesis Purines MAT dUMP Methionine Guanido AC THF Creatine Creatinine 5. 10 Methylene
glycine
Thymidine
synthesis
Purines
MAT
dUMP
Methionine
Guanido AC
THF
Creatine
Creatinine
5. 10
Methylene THF
SAMe
Pyruvate
mercury
SHMT
lead
serine
DMG
Tryptophan
Tyrosine
MTRR
DNA, RNA
B12
methylation
Protein, lipids
glycine
BHMT
Arginine
MTR
BH4
SAH
TMG
SAH
ALUM
Acetyl CoA
Ornithine
adenosine
oxaloacetate
ACAT
DHPR
NOS
MTHFR
AHCY
aspartate
UREA
5 Methyl
Homocysteine
citrate
LEAD
AMMONIA
THF
BH2
CBS
fumarate
Kreb’s
OTC
isocitrate
Cycle
VDR
cystathionine
succinate
α-ketoglutarate
Serotonin
Dopamine
NADH/FADH
MAO A
AMMONIA
SAMe
Cysteine + , α-ketobutyrate
NorEp
Citrulline + NO
HIAA
COMT
SAH
taurine
glutathione
Neuronal
Peroxynitrite
COMT
SAH
Damage
HVA
“When the need is for energy and not for
cysteine, homocysteine is metabolized to
Alpha-Ketobutyrate, NH3 and H2S.”
VMA
Microglial
Super Oxide
Text of Biochemistry with Clinical Correlations, Devlin 2002
Activation
cortisol
GST
SUOX
ACE
SOD
Angiotensin I
Angiotensin II
G6PDH
glutamate
gaba
0 BH4
2 BH4
1 BH4

Yasko Methylation Pathway

GAD

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