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Monitoring Organs 1895: first X-ray photograph: German physicist Wilhelm Roentgen. High energy electromagnetic waves pass through soft tissue (muscle), absorbed by denser bone. 1898: first X-rays of soft tissue (viewed without surgery): Walter Cannon developed stain w/ bismuth (nontoxic mineral opaque to X rays). Patient drank it, X rays unable to penetrate stained gastrointestinal organs = white image of organs. Today barium instead of bismuth. X Ray technology + computer technology. Example: computerized axial tomography (CAT) scan: X ray machine rotates around patient 100s of pictures from different angles. Images stored in computer w/ location and angle. Pictures reassembled thin cross-sectional views, organized for 3 d imaging. Organ viewed section by section. Accuracy: can detect 1 mm abrasions. Can distinguish between gases, liquids, solid tissues can identify tumours. Useful diagnostic tool head injuries (e.g. blood clots)
Usually, temp + = energy + = enzyme activity + Most human enzymes: efficiency peaks at 37 degs, drops as more energy is added. * enzymes = proteins when w/ high temp, change shape denatured = no longer active Enzymes function best within certain pH ranges. E.g. Pepsin = low pH (acidic environment of stomach). Amylase = neutral pH (mouth), Trypsin = basic environments (small intestine) Digestion in Simpler Organisms Protozoa: digest meals inside food vacuoles in cells Amoeba: single celled: engulfs food w/ phagocytosis: extends pseudopods to engulf food, vacuole formed inside cell. Vacuoles fuse w/ lysosome: vesicles containing hydrolytic enzymes: use water molecules to break down food. Hydra: digestive sac (gastrovascular cavity) w/ single opening. Encloses part of external environment, allows food storage and digestion. Digestive enzymes released, break down larger food molecules. Smaller molecules engulfed by cells lining cavity. Digestion continues in cytoplasm. Wastes remain, expelled from same opening. Digestion in More Complex Organisms Digestive tracts/ alimentary canals long tubes with 2 openings (mouth, anus) Moves along 1 direction Specialized regions: breakdown + absorption: stepwise process Food ingested through mouth muscular pharynx esophagus stomach/crop (depends on species) Animals w/o teeth have muscular gizzard(designed to break down food particles) intestine hydrolytic enzymes complete chemical digestion nutrients absorbed across lining of intestine into blood circulatory system cells of the body undigested wastes removed through anus. -
6.3 Ingestion
Saliva watery fluid produced by salivary glands amylase enzymes breaks down starches (complex carbohydrates) simpler lubricates food to be swallowed, dissolves food particles, makes it possible to taste Flavour: food particles dissolved in solution penetrate cells of taste buds on tongue and cheeks. Different types of receptors: special geometry: permit I.D. of flavours. Nerve cells for tastes stimulated receptor sites filled by chemical compounds w/ complementary shape. Digestive tract of humans (6.5 m to 9 m long) stores and breaks down organic molecules simpler components.
Teeth physical digestion incisors: 8 chisel shaped teeth at front: for cutting canine teeth: sharp, dagger-shaped, for tearing premolars: broad, flattened teeth, for grinding molars: broader, flattened cusps, for crushing wisdom teeth: 16-20 years of age. Often must be removed. 2 divisions: root and crown. Enamel crown (covers tooth w/ calcium compounds hardest substance in body). Inside Dentin (bonelike substance), part of root structure. Encases: pulp cavity (containing nerves and blood vessels) Tooth decay: bacteria living off nutrients that cling to teeth. Harmful microbes corrosive acids that erode tooths structure. Infections can spread to periodontal membrane anchors teeth to jawbone. Periodontal tissue can be destroyed, teeth loosen. Esophagus -
Food mouth stomach Bolus of food stretches walls, activates smooth muscles peristalsis (involuntary rhythmic contractions): moves food along gastrointestinal tract. Only times voluntary swallowing and egestion
Ulcers
Peptic ulcer (lesion): from destruction of the cell membrane by HCl and pepsin after protective mucous lining breaks down. Under thin layer of cells = rich capillary network. Acids irritate cells of stomach lining = increase in blood flow and acid secretions = more tissue burned = allergic reaction stronger = eventually blood vessels breakdown. Most linked to Heliobacter pylori bacterium. Other factors: diet, stress. Dr. Barry Marshall: Australian physician changed minds. Before: believed microbes unable to live in stomach. H. pylori can survive in harsh environment, only powerful antibiotics can kill. Research in U.S.: attempting to connect it with stomach cancer. Now: simple breath test for presence of H. pylori Frontiers of Technology: Ulcers and Lasers 1960: American physicist: Theodore Maiman: 1 laser. Medical applications: remove damaged tissues (stomach ulcers). Laser beam thinner than most scalpels, can seal small blood vessels. Reduces need for surgery. Endoscope : instrument fitted with light-emitting glass fibre positioned inside patients body. Can be used to view inside body. Tiny forceps, fitted in, extracts small pieces of tissue for biopsy.
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Protein Digestion protein digesting enzyme, trypsinogen from pancreas small intestine enzyme enterokinase converts trypsin breaks down long chain polypeptides shorter chain peptides. Second group, erepsins from pancreas/small intestine break bond between short chain peptides individual amino acids. Carbohydrate digestion amylase enzymes, continues digestion intermediate-size chains disaccharides. Small intestine disaccharide enzymes, disaccharidases monosaccharides Lipid digestion pancreas lipases: break down lipids. 2 types: 1) pancreatic lipase: most common, fats fatty acids + glycerol. 2) Phospholipase phospholipids Absorption: mostly in small, not large. Villi (long fingerlike tubes) increase SA (10fold increase). Cells of lining of each villus have microvilli (fine, threadlike extensions of membrane, further increase SA). Each villus capillary network, intertwining with lymph vessels lacteals (transport materials). Some nutrients absorbed diffusion, others actively transported. Carbohydrates + amino acids capillary networks. Fats lacteals.
E.g. Best internal temperature: 37 C, 0.1% blood sugar level, 7.35 blood pH. External environments change: air temperatures, foods, different demands on body from sports, etc. System of active balance has constant monitoring/feedback and special receptors sense info about blood sugar, body temperature, oxygen levels. E.g. homeostasis disrupted monitor sends signal to coordinating centre (brain) where normal limits are set info to appropriate regulator balance. E.g. Regulator adjustments: increase in heart rate during exercise, release of glucose (liver) to restore blood sugar levels. E.g. Regulation of blood sugar level. Chemical reactions ensure sugar concentration in blood appropriate level Relationship: insulin / glucagon. Increase in blood sugar level chemical receptors cause pancreas hormone insulin cells of liver and muscles (more permeable to glucose) liver excess glucose (not stored) glycogen (stored). Decrease in blood sugar level pancreas hormone glucagon conversion glycogen glucose body uses for immediate needs.
Homeostatic Control of Digestion Homeostatic controls before food is absorbed. Exerted by nervous and hormonal systems + nerves in stomach wall. Gastric secretions are produced before food in the stomach (when seeing food) + swallowing motions produce gastric juices. Hormones: e.g. secretin: released when acids small intestine with food absorbed in blood pancreas initiates release of substances raise pH of small intestine. e.g. Gastrin: (digestive hormone from stomach stimulates release of gastric juices to digest proteins): when partially digested proteins stomach. Also controlled: speed of digestive system processing food. Food stomach: nerves in stomach wall cause muscle contractions + secretion of gastric fluids. Large meal receptors more forceful stomach contractions + faster emptying. Fatty meal small intestine digestive hormone (enterogasterone) slows peristaltic movements = more time for fat digestion + absorption.