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nimesulide
“as a promising
neuroprotectant in
brain ischemia”
ABSTRACT
Nimesulide are…
Non-steroidal inflammatory drugs
COX-2 inhibitor
Most prescribed
1.
Excitotoxic
2.Traumat
ic
3. Neuroinflammatory
brain damage
Development of " excitotoxicity " in
response to ongoing pain signals from
an injured nerve. Illustration by Donald
Bliss, adapted from: Richard Gracely,
Susan Lynch, and Gary Bennett, Painful
neuropathy: altered central processing
maintained dynamically by peripheral
Neuroprotective by nimesulide against
other types of brain injury
: Evidence from in vitro and in vivo studies
Excitotoxic Important
mechanism
Excessive Loss of
+ionotropic homeostasis
glutamic and cell
receptor death
Induction of COX-2
following
excitotoxic injury.
Increase
prostanoid
Neuroprotective by nimesulide against
other types of brain injury
: Evidence from in vitro and in vivo studies
Excitotoxic
In vitro cortico-hippocampal neuronal cultures
Exposed to excitotoxic concentration of glutamate
(50uM)for 24 h.
Nimesulide (1uM) completely prevented chromatin
condensation and apoptotic cell death
Neurotoxicity induced by amyloid betapeptide(Aβ1-
40)in SH-SY5Y
Reduced by nanomolar concentration of nimesulide
Excitotoxic
Scali et al demonstrated that nimesulide diminish
excitotoxic brain injury induced by quisqualic acid
injection into the nucleus basalis.
Strong attenuated of microglial raction