DISRUPTIVE INNOVATIONS

Disruptive Innovation:
Moving Beyond the Talk
Thomas Krohn Eli Lilly & Company

Case for Disruptive Innovation

Productivity Down, Costs Up

Future revenues under pressure

Unsustainable Business Model

Source: FDA.gov

The Far Side by Gary Larson

Drug Development

Innovation
Precompetitive
patent

Process
Competitive
$200 $100 $$300

Typical Cost/NME/Phase

Millions US$

3 Challenges
Incremental vs. Disruptive Precompetitive vs. Competitive Closed vs. Open

Incremental Improvement

Clinical Research Improvement

Good, but not sufficient

Disruptive Innovation
to S1'

Performance

to S2

S1
Disruptive Change

Time

Simpler, Faster, Cheaper? Who is being disrupted?

Precompetitive vs. Competitive

Precompetitive

patent

Competitive

Collaboration should and can exist across model

Closed vs. Open

Trial Planning & Design Example
Todays Closed Fortress Model: Internal product teams Advisors Third party organizations Competitive = Secret Reality Distant from practice Small number Slow and expensive Nave

Time to explore other models

Experiment Portfolio
Open Clinical Intelligence Network
Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI

Open Clinical Intelligence Network

Worldbank

Motivation
Commons Licensing
Crowd
2. Consume 3. Curate

Uncurated Data

Clinical Knowledge Generation

Curated Data

1. Collect

4. Connect

Public Data

Technology
ROAR

Open Clinical Intelligence Network

Commons Licensing
Timeline Geographic Network Diagram Scatter Plot Export API

Crowd
2. Consume 3. Curate

Search/Filter Annotate Correct Cross Link API

Uncurated Data

Clinical Knowledge Generation

Curated Data

Trial Site Publication Drug Disease Regulatory

1. Collect

4. Connect

Public Data

Social Share Collaborate External Data Gamification

Knowledge Generating System

Krohn & Crist Whitepaper

From data to insights

Experiment Portfolio
Open Clinical Intelligence Network
Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI

Protocol Design
Crowd-based feedback

Protocol Design

Experiment Portfolio
Open Clinical Intelligence Network
Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI

Protocol Design
Crowd-based feedback

Site Training & Experience

Credentials, Training, Historical Trials

Predictive Analytics
Kaggle style enrollment projections

Predictive Analytics

Were making data science a sport.

Experiment Portfolio
Open Clinical Intelligence Network
Trials, Labels, Sites, CTM Reqs, Stds of Care, OpenAPI

Protocol Design
Crowd-based feedback

Site Training & Experience

Credentials, Training, Historical Trials

Predictive Analytics
Kaggle style enrollment projections

Q&A Forum
Site to site sharing, clinical research topics

Q&A Forum

So What?
If...
Incremental improvement is a slow death, Competitive mindset is stopping collaboration, and, Closed model is part of the problem

Thencheck your assumptions:

Incremental vs. Disruptive Precompetitive vs. Competitive Closed vs. Open

Time to Engage!
The case is clear The opportunities are many The question is leadership

Tide is rising for disruptive change. Are you on board?

Thanks

Thomas Krohn krohnta@lilly.com Eli Lilly and Company www.lillycoi.com