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Ag
(Yoes Prijatna Dachlan, 2010)
Ag
(Stewart,2004)
Ag receptor of B lymphocytes
Opsonization of bacteria
Opsonization of bacteria
Ag can bind in pockets or grooves or on extended surfaces in the binding sites of Abs
(Stevens, CD.,2010)
(Kuby, 2006)
(Kuby, 2006)
IgM
IgA
(Gabriel Virella, 2007, Med Immunol, 6th ed., p55) (Yoes Prijatna Dachlan, 2010)
(Kuby, 2006)
IMMUNOGLOBULIN SUPERFAMILY
B cell
CD80/CD86
CD40 D
CD28
CD40L
TCR
*
CD4
MHC Class II
ICAM-1 ICAM-3 LFA-3
LFA-1 CD2
mIg B
Signaling functions between Th B cell interaction A : TCR signal transduction B : Activation and proliferation of the B cell C : Co-stimulatory signals to the responding T cells D : Helps to drive B cells into cell cycle E : Receive signals from the T cells for division and differentiation
(Yoes Prijatna Dachlan,2010)
Mechanisms of Ab synthesis
Ehrlichs side chain hypothesis : is close to to the present view of clonal selection Dreyer & Bennett : one gene, one polypeptide dogma untenable Proved D & B hypothesis; somatic recombination
(Yoes Prijatna Dachlan, 2010)
(Janeways.ImmBiol., 2008)
(Janeways.ImmBiol., 2008)
(Stevens, CD.,2010)
Chromosome H M 22 16 2 6 14 12
Isotype switching