Prepared by: Ms.

Cherry Ann Guevarra-Garcia, RN MS Lecturer RA Gapuz Review Center

Drug Class: Alkylating Agents Meds: Busulfan, Chlorambucil, Cyclophosphamide

MOA: Alter DNA structure by misreading codes Side Effects: Bone marrow suppression Nsg. Consideration: Monitor for pancytopenia; Avoid trauma or bleeding

Drug Class: Antimetabolites Meds: Methotrexate, 5-fluorouracil, hydroxyurea MOA: Interfere with the synthesis of metabolites for RNA and DNA synthesis Side Effects: Bone marrow suppression, Renal toxicity Nsg Consideration: Methotrexate causes decreased folic acid = give Leucovorin calcium

Drug Class: Antitumor antibiotics Meds: Bleomycin, Doxorubicin, Dactinomycin MOA: Prevents RNA synthesis Side Effects: Nausea and vomiting, dental caries, cardiotoxicity Nsg Consideration: Oral hygiene, Fluid replacement

Breast cancers occur anywhere in the breast, but most are found in the upper outer quadrant, where most breast tissue is located. Generally, the lesions are nontender rather than painful, fixed rather than mobile, and hard with irregular borders rather than encapsulated and smooth.

Risk Factors: BRALESS

B- BRCA gene mutation R Radiation exposure A- Age greater than 50 L Late menopause (over 55y/o) E Early menarche (before 12 y/o) S- Sonless (nullipara)/ firstborn at 30 S Sick relatives (1st degree relatives)

Protective Factors: ADOBE

A Appropriate maternal age (20-30) D Doing BSE and mammography @ 50 O - Obesity B Breastfeeding/Pregnancy E Exercise

Breast-imaging technique that can detect nonpalpable lesions and assist in diagnosing palpable masses Procedure lasts about 20 minutes Do not use deodorant, perfumes, or powder before the procedure