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Human physiology is concerned with the way the human body works. It is the study of the functions of systems and organs. Organs consist of tissues which are formed of cells
40 % inside the cells -Intracellular fluid -Main cation is K+ -Main anion protein & phosphate
20% outside the cells -Extracellular fluid -Main cation is Na + -Main anion is Cl - & HCO3
4% plasma
Diffusion Passive- no energy Occurs through lipid bilayer or protein channels 2 types -Simple -Facilitated- needs carrier
Active transort Occurs against electrochemical gradiant Needs carrier, energy ATP, ATPase 2 types -Primary active e.g Na + - K + pump -Secondary active
Electric properties of the neuron 1- Nerve excitability the ability to respond to a stimulus ( a stimulus is a change in the environment) 2- nerve conductivity conduction of action potential along the length of nerve fiber Velocity of conduction is increased by increasing the diameter of nerve fiber & it is faster in myelinated nerve fibers
Nerve excitability
The ability to respond to a stimulus Threshold stimulus is the minimal stimulus needed to excite the nerve & produces action potential Types of membrane potential - resting membrane potential - action potential
Action potential
It is the rapid change in membrane potential following stimulation of the nerve by threshold stimulus. Phases& shap latent period is the interval between stimulus application & start of action potential. Depolarization Membrane potential decreases slowly from 90 mV to 65mv ( firing level) then become rapid until it overshoots the isopotential and reach + 35mV Repolarization membrane potential returns to resting level It starts rapidly then slows down and overshoots in opposite direction to form small prolonged hyperpolarization then RMP is reached gradually
Ionic basis of action potential Depolarization is produced by Na + inflow through voltage gated Na + channels Electric stimulation opens some voltage gated Na + channels, flow of Na + causes more depolarization & more opening of Na channels till membrane potential reach -65 mv ( firing level) ,then all Na channels are opened Repolarization is caused by K + outflow through voltage gated K + channels Hyperpolaization is caused by slow closure of K + channels Re-establishing of Na + & K + gradient after action potential by Na + - K + pump
Physiology of muscle
Muscles are divided into two types
Striated muscles skeletal& cardiac muscles Smooth muscles no striations 40% of the body is skeletal muscles, 10% is smooth and cardiac muscles
Skeletal muscles
Attached to bones Striated muscle 40% of the body Functions locomotion, breathing, posture, heat production, venous drainage
myofibrils
myosin filaments myosin molecules consisted of 2 heavy chains & 4 light chains forming helix & heads ( cross bridges) . Heads contains actin binding sites, ATP binding sites & a catalytic site that hydrolyses ATP. Actin filaments F- actin molecules forming helix & have active sites which combine with cross bridges of myosin (ADP). tropomyosin molecules strands cover the active sites of actin under resting condition. troponin troponin I for actin - troponin T for tropomycin tropnonin C for calcium Titin framework lining up the actin & myosin filaments
Electrical changes
-Resting membrane potential .. -90 mV -Action potential.. 2- 4 msec depolarization & repolarization precedes contraction by 2 msec -Action potential in muscle results from nerve impulse arriving at neuromuscular junction
Neuromuscular junction
It is the junction between motor neuron & muscle fiber (motor end plate MEP)
Myasthenia gravis - Autoimmune disease - antibodies against Ach receptors - weakness of skeletal muscles
Mechanical changes
(Excitation contraction coupling) it is the process by which an action potential initiates the contractile process. It involves 4 steps: 1- calcium release from sarcoplasmic reticulum. 2-activation of muscle proteins and sliding of actin over myosin 3- generation of tension 4- relaxation