BIOINFORMATICS DEVELOPMENTS IN INDIA

Dr. T. Madhan Mohan Madhan.dbt@nic.in Director Department of Biotechnology New Delhi

http:www.btisnet.gov.in/www.dbtindia.gov.in

Agriculture Crop
Aquaculture Sericulture

Medical Human Resource Development

Diagnostics

Bioinformatics

Vaccines Infectious diseases Cancer and chronic diseases Stem Cell

Biofertilizer
Biopesticide

Societal Development Basic Sciences Biomaterial and

devices Bioengineering RNAi Nanobiotechnology

DBT

Genomics Bioresources Forestry

Plant

Programmes

Animal

Environment
Bioremediation Pollution abatement Conservation

Food & Nutrition Security

Biosafety guidelines, regulation and IPR

Medicinal & Aromatic plants Microbial Bioprospecting

Biofuel

Bioinformatics in India
Department of Biotechnology created in 1986 Bioinformatics programme started ever since Biotechnology Information System Network (BTISnet) in 1987 BTISnet today has 65 institutions and universities Emphasis on infrastructure creation and human resource development Biotechnology in India has greatly benefited from the capacity building in Bioinformatics Dedicated virtual private network connecting the major centres sharing of data as well as computing resources

Major Achievements: BTIS

First Distributed Science Network Sensitization of life scientists for use of computers Driven the better infrastructure for networking and visualization Improvement of Quality of research in modern Biology/Life Sciences

Structure of BTISnet Structure of BTISnet

Bose Instt. IISc. JNU MKU Uni. Of Pune

BI Services

CoE

I
D
Graphics
)
(5)

Sub DIC
HPU IICB IISR IITD IITK IVRI ILS MGIMS MSSRF NRBRI INDRI NIO NEHU PAU RGCB RRL STSIKKIM TMBHAG. TNAU TNVASU TBGRI DU UAS KU

C APEX BTIC E

DIC
Anna CCMB IARI IMT KAU MSU NBRC NII Pondicheery Univ. Univ. of Calcutta

ACTREC AMU AIIMS AAUI OBioinformatics R&D BHU BU BV BUT BISR BIT BCIL BPBC CARI CDRI CIFA CIMAP CPCRI CSRTI CSKKV YSPU DAVV EC GBPANT GNDU

Man power

Development

(10

(5 0

Bioinformatics Facilities in India

BIOGRID INDIA
Internet

MK Univ., Madurai

South Campus, DU, Delhi

IGIB, Delhi

Service Providers VPN Network

IMT, Chandigarh Deptt. Of Biotecdhnology, Delhi

Univ. of Pune

IIT, , Delhi

CDFD, Hyderabad

Router

IISc, Bangalore

NBRC, Gurgaon

NII, Delhi JNU, Delhi

MIRROR SITES
EMBnet (CDFD) PDB (IISc & University of Pune) GDB (IISc.) EBI Databases (Pune) Plant Genome Databases (JNU) Public domain Biotech Software (IMTECH)

Educational Activities of India in Bioinformatics Two forms of initiatives are in operational

Short-Term Training
Nationwide trainings and workshops Presently around 100 organised per year in seven defined areas More than 10000 trained so far

Long-Term Training
Advanced Diploma Courses in five universities M.Sc., M.Tech., Ph.D. courses in Bioinformatics

Job opportunities in Bioinformatics

Qualification
1) Post graduates and ,Doctorates

Experience
Formal Training and understanding market requirement of Bioinformatics

Job Title
Group leaders /

Sr. Executives /
Scientists/ Faculties

2) Bachelor degrees / 3 year diploma holders

Sound knowledge in Molecular Biology and programming

System Analyst Technical Asst./ Programmer /

3) Degree with one year course in computers

Good typing speed, Knowledge in molecular Biology and computer application

COs / DEOs

INTEGRATION OF BIOTECHNOLOGY DATABASES ON BTISNET

BioGrid Nodes/ Server [High Speed Network]

Medical Biotechnology Agricultural Biotechnology Medicinal or Aromatic Plants Animal Biotechnology Aquaculture & Marine Biotechnology Biodiversity Databases Mirror Sites on Major Databases Molecular Biology BTISNet Software package

1. 2. 3. 4. 5. 6.

In-house software development GeneScan, GenEvolve,

PROCOR PLHOST APSSP (Protein structure prediction), MHCBN PCR: s/w for setting PCR reactions LOOPSEARCH, CONFPLOT VirGen, CE, AVIS

1. 2. 3. 4. 5. 6. 7. 8.

7.

8.

Micro array analysis (Avadis), Genome annotation (Acuris), Oligonucleotide probe design (Sarani) BioSuite

JNU, Delhi IGIB, Delhi IMTECH, Chandigarh Devi Ahilya University Bose Institute, Kolkatta University of Pune, Pune Strand Genomics, Bangalore TCS, Hyderabad

These efforts needs to be strengthened with Human resource development

Integration of Bioinformatics & Biotechnology

Collaborative effort RFP (Request for Proposals) in following areas:
Parasitic diseases Agro-biotech Herbal medicine Clinical Data management

Major Research Areas in Bioinformatics

Gene Analysis
Research Activities [%]

Prot. Struc. Pred. Prot Design & Folding

15 %

2% 20 % 8%

Macr. Modelling Evol. Biol. Struc-Func Studies

8%

30 % 15 %

20 %

Mech. Of Diseases Mech. of Dis.

Data Mining Stud

Total number of Research Publications in last two years is 392

Phenotype

Genetical Genomics

Computational Genomics

Statistical Genomics

Functional Genomics

Functional Genomics ?
Genome sequence mRNA: Transcriptomics Protein: Proteomics Metabolites: Metabolomics

Forward Genetics

Phenotype

Reverse Genetics

Need of Tie ups between Wet & In-Silico Labs

Wet Lab Experiments(High throughput technologies)

In-Silico technologies

(Bioinformatics)

Knowledge Discoveries Products

Strategic alliance & Partnerships

IT Industries Software Expertise Hospitals for Clinical records

Academic & R&D Institution

BIOINFORAMTICS

Pharma Companies

Hardware Supplies
Biotech Companies

Health Care System

Bioinformatics Market

Global Bio-Informatics Market 1.2bn In 2004

Overall Market Size Projected to reach USD 1.7 bn by 2006

Indian Bioinformatics Market has touched USD22 Million in 2004 Indian Bioinformatics is growing at the rate of 40% per annum (Source: CII)

Areas of opportunity in India

Bioinformatics Vaccines, dignostics and therapeutics Biomedical devices, instruments and sensors Bioartificial organs using tissue engineering and stem cells Clinical trial and contract research Agriculuture disease and pest resistant, drought and salinity tolerant seeds and plants Biofertilisers and Biopesticides

Advantages for India

Strong IT capabilities R & D strength in Modern biology Highly trained manpower in biotechnology and Bioinformatics Rich Biodiversity Diverse ethnic population Strong Biotechnology Infrastructure Wide Networking of Institutions and Scientists. Industrial enterprise.

Invitation to InCoB2006-http://www.incob2006.in

International Conference on Bioinformatics (InCoB)

InCoB is the annual international conference of the Asia Pacific Bioinformatics Network (APBioNet). The main objective of the InCoB is to provide a platform for experts and budding bioinformaticians to discuss and exchange ideas and cards on the development of Bioinformatics in the Asia Pacific region.

Asia Pacific Bioinformatics Network (APBionNet)

The Asia Pacific Bioinformatics Network (APBioNet) is a non-profit, non-governmental, international organization. It focuses on the promotion of bioinformatics in the Asia Pacific Region. Since 1998, its mission has been to pioneer the growth and development of bioinformatics awareness, training, education, infrastructure, resources and research amongst member countries and economies. Its work includes the technical coordination and liaison with other international bodies such as the EMBnet.

Date and Venue (Tentative)

1. Date: Decembers 18th 20th, 2006

2. Venue: Ashoka Hotel, New Delhi

Organizing Institutes

Indian Institute of Technology www.iitd.ernet.in www.scfbio-iitd.res.in

Jawaharlal Nehru University www.jnu.ac.in

Concluding Remarks
India is well placed to take up global leadership in genome analysis as is in a unique position in terms of genetic resources has several ethnic population that are valuable in providing information about diseases predisposition and susceptibility, which in turn will help in drug discovery.

Welcome to InCoB2006 18-20th December 2006, New Delhi, India, Pl. visit www.incob2006.in Thank you.