Академический Документы
Профессиональный Документы
Культура Документы
Infectious and Tropical Pediatric Division Department of Child Health Medical Faculty, University of Sumatera Utara
Transmission of CMV through the placenta barrier and infection of the fetus
Infected mother viraemia infection of placenta trophoblasts
Infection of the oropharynx Virus in amniotic fluid Infection of fetal endothelial cells
Fetal viraemia
- 5-17% of newborns with asymptomatic congenital CMV infection develop neurological sequelae (esp. hearing loss)
CHORIORETINITIS
Congenital CMV
Congenital CMV
Chorioretinitis
15%
12%
CMV IgG antibody sensitive and specific screen for past infection CMV IgM antibody variable sensitivity and specificity Antibody avidity testing can increase accuracy of detection of primary infection
CKS
50 40 30 20 10 0 0 5 10 15 20 25 30 35
Positive
Negative
Retest later
Problems
No proven means to prevent maternal infection will be normal
Use prenatal diagnosis, ~75% infected fetuses abort infected fetus Use antivirals to prevent No available antiviral or treat fetal infection
Phase lll randomized trial of ganciclovir for symptomatic congenital CMV infections involving the CNS
100 Neonates enrolled to receive 6 weeks of IV ganciclovir (6 mg/kg/dose q 12 hours) No significant difference in mortality (6% GCV, 12% untreated) Hearing Improvement was more likely in the GCV treated group at 6 and 12 mos (OR 4.31, 4.03)
29/46 (63%) GCV recipients experienced neutropenia, compared with 9/43 (21%) untreated control patients
Hygiene, especially
handwashing
The End