Академический Документы
Профессиональный Документы
Культура Документы
http://saphir.physiome.fr/
SAPHIR:
"a Systems Approach for PHysiological Integration of Renal, cardiac, and respiratory functions"
oxygen delivery
muscles
thirst kidney
ADH control
circulatory dynamics
autonomic control
heart rate
SAPHIR (cont.)
Na, K, Cl, glucose, urea, blood pH, HCO3, CO2, O2, Ca++, Mg++, mannitol, blood hemoglobin, COP, phosphate, sulfate, NH4+
Ikeda, N., et al., "A model of overall regulation of body fluids". Annals of Biomedical Engineering, 1979. 7:135-166.
Outline
Guyton's 'engineering' approach to BP regulation Why regulate blood pressure? What are the problems for BP control? The hierarchy of pressure control systems. Relevant principles of Control Theory
2. (corollary of (1)): avoid interference/competition among the organs for blood supply e.g., in sympathectomized dogs, exercise leads to dramatic fall of BP in the brain..
4. Keep BP high enough to supply all organs (>80mmHg), but low enough to avoid damage to the vascular system
2. Provide appropriate short-term changes in the circulatory system in the face of the many acute stresses we encounter
entirely independent of blood volume changes (too slow)
must ensure adequate perfusion of all organs, but esp. the brain and the heart
depends on controlling strength of the heart, capacity of blood vessels, and total peripheral resistance (TPR)
2. The body's approach: a hierarchy of short- and medium-term damping and long-term control
short-term (seconds to minutes)
cardiovascular reflexes mediated by the nervous system
from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
10
Gain: (max-final)/(final-normal)
Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
11
Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
12
VIM: Blood viscosity PA: aortic pressure PPC: plasma COP RBF: Renal Blood Flow REK: percent of normal renal function CNE: third factor effect AHM: ADH multiplier AM: aldosterone multiplier
OUTPUTS NOD: rate of renal Na+ excretion VUD: rate of urine output
glomerular filtration
volume reabsorption
sodium excretion
CNE AHM AM
NOD VUD
Guyton, A.C., T.G. Coleman, and H.J. Granger, "Circulation: Overall regulation." Annual Reviews of Physiology, 1972. 34:13-44. 13
The Infinite-Gain feature of the kidney - blood volume - pressure regulator: The (acute) renal function curve
from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
14
The Infinite-Gain feature of the kidney - blood volume - pressure regulator: The (acute) renal function curve and Net sodium intake
from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
15
The Infinite-Gain feature of the kidney - blood volume - pressure regulator: The acute vs. chronic renal function curves
from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
16
from Guyton, A. C. (1980). Circulatory Physiology III. Arterial Pressure and Hypertension. Philadelphia, W.B. Saunders.
17
AQP2-3
18
19
http://saphir.ibisc.fr/
20