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By G.S.JeraldJasper
Why Bioinformatics?
Study
Answer
Improve
accuracy.
converting
data to information.
Bioinformatics defined
Bioinformatics
Computational
biological systems at various levels of complexity atomic, metabolic, cellular and pathologic
Bioinformatics Data
DNA
sequences
Protein
Sequences
Protein/RNA
structures
Gene
expression
Biological Databases
Almost
databases.
Important databases
Text
Sequence
Protein
and CATH.
Database growth
Protein Structure
Protein Function
Phenotype (Symptoms)
Areas in Bioinformatics
Genomics Proteomics Protein
Structure Prediction
Phylogenetic
Genetic vs Genomics
Genetics
Genomics
is the study of
functions and interactions of all the genes in the genome, including their interactions with environmental factors.
in sequence data needle in a haystack as the needle is different from the haystack
However
genes are not different from the rest of the sequence data
This
Neural
being employed
Organism
Web Site
Yeast
13.5
6,241
Fruit Flies
180
13,601
Homo Sapiens
3,000
45,000
Proteomics
Proteome
proteins
More
especially biochemistry
Phylogenetics
The
taxonomical system reflects evolutionary relationships Phylogenetic tree reconstruction algorithms are also an area of research
Applications
Medical
Pharmacogenomics
Customized treatment
Gene Therapy
Bioweapons (??)
Other Applications..
Diagnosis
of Disease
Identification of genes which cause the disease will help detect disease at early stage.
Drug
Design
One of the goals of bioinformatics is to reduce the time and cost involved with it.
Computational methods can improves this
Target
identification
the molecule on which the germs relies for
Identifying
its survival Then we develop another molecule i.e. drug which will bind to the target So the germ will not be able to interact with the target. Proteins are the most common targets
For example HIV produces HIV protease which is a protein and which in turn eat other proteins This HIV protease has an active site where it binds to other molecules So HIV drug will go and bind with that active site