ZILELE MEDICAMENTULUI EDITIA A XX a IASI

19 -20

MAI

2011

VICTOR COJOCARU

STUPOARE, CONSTERNARE, REVOLTA, ANXIETATE, DEPRESIE, FRUSTRARE, RESEMNARE

Durerea apare odata cu primele vietati dotate cu

sisteme nervoase integrate si nu pare ca se va sfarsi decat odata cu disparitia omului.

Experienta durerii se inregistreaza si in timpul starilor

inconstiente dar greveaza mai ales experienta constienta, sculptand noua viata a omului ganditor.

RETEAUA CEREBRALA A DURERII

A. Vania Apkarian, Yamaya Sosa, Sreepadma Sonty, Robert M. Levy, R. Norman Harden, Todd B. Parrish, Darren R. Gitelman - Chronic Back Pain Is Associated with Decreased Prefrontal and Thalamic Gray Matter Density, The Journal of Neuroscience, Nov. 17, 2004 . 4(46):10410 10415

Baliki MN, Chiavlo DR, Geha PY, Levy RM, Harden RN,Parrish TB, Apkarian AV- Chronic Pain and the Emotional Brain: Specific Brain Activity Associated with Spontaneous Fluctuations of Intensity of Chronic Back Pain, The Journal of Neuroscience, Nov 22, 2006, 26(47): 12165-12173.

Baltki MN, Geha PY, Apkarian AV, Chialvo DR Beyond Feeling Chronic Pain Hurts the Brain, Disrupting the Default-Mode Network Dynamics The Journal of Neuroscience, Feb 2008, 28(6):1398 1403

EXTENSIA AFECTIVA A DURERII

SEMNAL NOCICEPTIV
(Spino-ponto-amigdalian, Spino-hipotalamic) (Spino-talamic, Spino-reticulat, Cordonul dorsal)

(Form. Reticulat, N parabrahial, Amigdala, Aria sup. motorie, Hipotalamus)

DECLANAREA ACTIVRII VEGETATIVE/ SOMATOMOTORII

SENZAIA NOCICEPTIV

(S1, S2, Anterior insula, Cingulat posterior)

EVALURI I SEMNIFICAII COGNITIVE 1) AGRESIUNE 2) AMENINARE

(7b, Cortex parietal post., Cortex cingulat anterior)

FAZA 1 AFECT

EXPRESIA DURERII
(Sistemul somatomotor i cel vegetativ)

(Arii corticale prefrontale)

1) BLOCARE 2) DIFICULTATE 3) NGRIJORARE PENTRU VIITOR

FAZA 2 AFECT

Bastian B, Jetten J, Fasoli FV -Cleansing the Soul by Hurting the Flesh: The Guilt-Reducing Effect of Pain. Psychological Science, March 2011; vol. 22, 3: pp. 334-335.

Eisenberg DP, Kohn PD, Baller EB, Bronstein JA, et al Seasonal Effects on Human Striatal Presynaptic Dopamine Synthesis, J Neurosci 2010, 30(44):14691-4.

Marjolein P.M. Kammers, Frdrique de Vignemont, Patrick Haggard - Cooling the Thermal Grill Illusion through Self-Touch, Current Biology, Vol 20(20) 26 October 2010, 1819-1822.

Rainville P, Duncan GH, Price DD, Carrier B, M. Catherine Bushnell Bushnell MC - Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex, Science 1997: Vol. 277 no. 5328 pp. 968-971

Ploghaus A, Charvy N ,Beckmann CF et al, Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network , The Journal of Neuroscience, 15 December 2001, 21(24): 9896-9903

DeWall CN, Macdonald G, Webster GD et al - Acetaminophen reduces social pain: behavioral and neural evidence, Psychol Sci. 2010 Jul;21(7):931-7