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Damla Taykoz 2020110077 BioTech 580



1) Fenfluramine/phentermine (Fen-Phen)
Wyeth-Ayerst Laboratories now Pfizer It is estimated that as many as 6.5 million people took it to help fight obesity Recalled: 1997 (after 24 years on the market)

Financial damage: Awards to victims close to $14 billion, making it one of the most costly products liability cases in history.

Linda M. took both diet drugs for about 18 months

Cindy Cartwright took drug for 6 monts has had to have three of four heart valves replaced

2) Diethylstilbestrol (DES)

Maker: Multiple manufacturers Recalled: 1975 (after 37 years on the market) Financial damage:Each manufacturer paid out legal damages correlated with its respective market share.

3) Cerivastatin (Baycol)
Maker: Bayer

Recalled: 2001 (after four years on the market)

Financial damage:$1.2 billion

Baycol, prescribed to patients as a treatment for high cholesterol, is reportedly responsible for more than 100,000 deaths

4) Rofecoxib (Vioxx)
Maker: Merck Recalled: 2004 (after five years on the market) Financial damage: $6 billion

5) Valdecoxib (Bextra)
Maker: Pfizer Recalled: 2005 after one year on the market. Financial damage: Over $2 billion

Rofecoxib was approved by the Food and Drug Administration (FDA) on May 20, 1999 Vioxx is considered to be the largest drug recall in history, and one which elicited one of the greatest public outcries. Vioxx, prescribed to more than 20 million people as a pain reliever for arthritis, was found to be responsible for increased risk of heart attack and stroke.

6) Troglitazone (Rezulin)
Maker: Warner-Lambert Recalled: 2000 (after one year on the market)

Financial damage: Warner-Lambert grossed $2.1 billion in sales before recall

7) Phenylpropanolamine (PPA)
Maker: No principal manufacturer Recalled: in 2000 (at least 60 years on the market) Financial damage: untold millions

8) Thalidomide

Sources and References www.fda.org www.pubmed.com www.pfizer.com www.cumc.colombia.edu www.drugbank.ca http://www.agcs.allianz.com/ http://www.petroffassociates.com http://www.shifa.com.pk www.cnn.com www.bbc.co.uk www.nyu.edu http://science.education.nih.gov http://www.nanogenpharma.com www.cartoonstock.com http://www.heart-valve-surgery.com http://www.lawyersandsettlements.com https://www.facworld.com/ http://desinfo411.wordpress.com/des-timeline/ http://www.huffingtonpost.com/ http://www.drugbank.ca/drugs/DB00255 Bilim ve Teknikl Dergisi G E Mitchell and D R Mottram, Peripheral effects of fenfluramine, Br J Pharmacol. 1976 June; 57(2): 185189.