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Bhuvanesh SK
2nd Sem Microbiology
DSBS Bangalore
Retrovirus replication
Index
General structure
Retrovirus replication
-Reverse transcription
-Integration
Conclusion
Questions??
Retroviral structure and genome
Retroviral Proteins
Type B (eccentric)
MMTV
Type C (central)
ALV,RSV
Type D (bar)
Lentivirus (cone)
HIV
Virus Replication
cytosine arabinoside
Three forms of provirus DNA are found
in all infected cells:
Steps in retroviral DNA integration
The two ends of viral DNA are
recognized, nicked and then joined
covalently to host DNA in random
locations at staggered nicks also
introduced by Integrase