You are on page 1of 20

Presented by Marina Ceban

1. Introduction
2. What is Alzheimers disease?

3. Characteristics
4. Causes 5. Diagnosis 6. The future of Alzheimers disease.

Alzheimer's disease (AD), also known in medical literature as Alzheimer disease, is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death. It was first described by German psychiatrist and neuro pathologist Alois Alzheimer in 1906 and was named after him.

Disrupts the message carrying transmitte rs

Destroys brain cells and nerves


Contains lower levels of message chemicals

Brain disease

The disease course is divided into four stages, with progressive patterns of cognitive and functional impairments.

Pre-dementia
Early stage. Moderate or Mild stage. Advanced/Severe stage.

Age

Family history

o Mild forgetfulness o Difficulty of

completing everyday tasks o Forgetting simple words o Getting lost

Forgetting names and recent events

Changing personalities

Problems with Speech

Sleeping more than usual

Alzheimer's disease is usually diagnosed clinically from the patient history, collateral history from relatives, and clinical observations, based on the presence of characteristic neurological and neuropsychological features and the absence of alternative conditions. Advanced medical imaging with computed tomography (CT) or magnetic resonance imaging (MRI), or positron emission tomography (PET) can be used to help exclude other cerebral pathology or subtypes of dementia.

PET scan of the brain of a person with AD showing a loss of function in the temporal lobe.

Tools to Diagnose Possible AD


General health

Past medical

problems
Difficulties carrying

out daily activities


Medical tests Memory tests Brain Scans

Nerve cells die in

regions of the brain Gaps develop in the temporal lobe and hippocampus The brain shrinks Protein fragments make tangles and plaques

Theories
Treatments

Possible Vaccine

Herpes simplex virus type 1 has also been proposed to play

a causative role in people carrying the susceptible versions of the apoE gene. Another hypothesis asserts that the disease may be caused by age-related myelin breakdown in the brain. Iron released during myelin breakdown is hypothesised to cause further damage. Homeostatic myelin repair processes contribute to the development of proteinaceous deposits such as beta-amyloid and tau. Oxidative stress and dys-homeostasis of biometal (biology) metabolism may be significant in the formation of the pathology

Supplements (Example are anitoxidants, Vitamins, melatonin, Ginkgo Biloba, and CoEnzyme Q10)

Treatment Cholinesterase inhibitors:

Donepezil (Aricept)
Galantamine (Razadyne) Rivastigmine (Exelon)

Immunotherapy (bapineuzumab)
Tricylic antidepressants

Early attempt (2002) Fights beta-amyloids Anxiolytics (short-acting) Lorazepam (Ativan) Oxazepam (Serax) Temazepam (Restoril) Zolpidem (Ambien) Triazolam (Halcion)

Alzheimers disease is a terminal disease which

despite being more than 100 years since its discovery has no known or effective cure.
As of now, if the people of the world neither get

treatment nor try to prevent it, it is estimated that by 2050, there will be about 50 million patients of alzheimers disease.

1.

2.

3.

4. 5. 6.

Wikipedia, the free Encyclopedia: http://en.wikipedia.org/wiki/Alzheimer's_disease#Other_hyp otheses Revista News medical online: http://www.newsmedical.net/health/Alzheimers-Disease-Symptoms(Romanian).aspx Cum se lupta cu boala Alzheimer, articol de ILARIA CARARE: http://www.formula-as.ro/2008/816/sanatate-35/cum-selupta-cu-boala-alzheimer-9496 http://www.doctissimo.fr/html/dossiers/alzheimer.htm Article sur la Maladie d'Alzheimer : causes, symptmes et volution:http://www.douglas.qc.ca/info/alzheimer :http://www.newsmedical.net/health/Alzheimers-Disease-Causes(Russian).aspx