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THERAPIES
Palmoplantar Keratodermas
Keratolytics are the mainstay of therapy. Corticosteroid therapy Use of topical & oral retinoids has also been described.
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0.1%
5% q.s.
Antiproliferative actions.
Reduces hyperplastic tissue characteristic of psoriasis & palmoplantar keratodermas.
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METHOD OF ADMINISTRATION
Apply thin layer to affected skin areas once or twice daily.
Maximum daily dose is 15 gm applied, should be no more than 30% of body surface.
Treatment duration for longer than 3 weeks has not been evaluated.
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SPECIAL POPULATIONS
Paediatric use
Safety & efficacy of Momate-S has not been established in children below age of 12 years.
COMPARATIVE EFFICACY
Studies have indicated superiority of combination (mometasone furoate 0.1% + salicylic acid 5%) over mometasone furoate 0.1% alone. After 3 weeks improvements in total disease scores (65 to 75% with combination) compared to 61 to 68% with mometasone alone. Combination was superior to topical salicylic acid 5% alone, improvement in total disease signs scores after 21 days was 75% with the combination & 39% with salicylic acid alone. Combination was more effective than topical fluocinonide 0.05%.
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CONTRAINDICATIONS
Hypersensitivity to mometasone, salicylic acid or any component in this preparation. As with other topical glucocorticoids, contraindicated in patients with bacterial (e.g, pyodermas, syphilis, & tuberculosis), viral (e.g., herpes simplex, varicella, herpes zoster, warts, genital warts, warts), or fungal (dermatophytes and yeasts), & parasitical infections & in patients with perioral dermatitis, rosacea, acne vulgaris, & skin atrophy.
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ADVERSE REACTIONS
Less common (1/100-1/1000) Skin: Striae, secondary infection, papulous rosacea like dermatitis (chronic disease of facial skin), ecchymoses (skin discoloration), folliculitis. Rare (<1/1000)
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COMPETITION
Brand Name Company Composition Packing Price
Betnovate-S cream
GlaxoSmithkline
20 gm
17.19
Diprovate-MF Croslands Cream Dipsalic Ointment Dipsalic Lotion Lupiderm-S Cream Fulford Fulford Lupin
Betamethasone dipropionate 0.05%,10 gm 37.00 Salicylic acid 3%, Urea 10%, Lactic acid 3%; Sodium lactate 2% Clobetasol propionate 0.05 %, 10gm Salicylic acid 30mg per gm Clobetasol propionate 0.05 %,10 ml Salicylic acid 20 mg per gm Betamethasone (as dipropionate) 0.05% w/w, Salicylic acid 3% w/w
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COMPETITION
Brand Name Saltopic Ointment Orkid-S Ointment Keralin Ointment Clop-S Cream Lobate-S Ointment Company Systopic Indchemie East India Camlin Nicholas Composition Betamethasone dipropionate 0.64 mg, Salicylic acid 30 mg, per gm Halcinonide 0.1% w/w, Salicylic acid 6.0% w/w Packing 20 gm 10 gm Price 33.50 63.00 31.76 55.00 40.10
Hydrocortisone acetate 0.5%, 15 gm Salicylic acid 6%, Benzoic acid 12%, w/w Clobetasol propionate 0.05%, Salicylic acid 3% Clobetasol propionate 0.05%, Salicylic acid 3%, Urea 10%, Lactic acid 3%, Sodium lactate solution equivalent to lactic acid 2%
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20 gm 15 gm
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