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Composed of glands that secrete hormones into the circulatory system. Hormones are secreted in minute amounts into the interstitial space. Hormones eventually enter the circulatory system and arrive at specific target tissues.
Hormones are only active in the body for a certain time because they are destroyed and eliminated shortly after they are secreted. Half-life = length of time that it takes to eliminate half of the total amount of hormone that was secreted.
Water-soluble hormones have relatively short halflives because they are rapidly broken down by enzymes. These hormones normally have concentrations that increase and decrease rapidly in the blood. They generally regulate activities that have a quick onset and a short duration.
Lipid-soluble hormones are usually bound to protein carriers. The rate at which these hormones are broken down is greatly reduced. Therefore, these hormones have longer half-lives.
Pituitary Gland
Divided into a posterior and anterior portion. Posterior pituitary is also known as the neurohypophysis, because it is continuous with the brain. Anterior pituitary is also known as the adenohypophysis, because it acts more as a gland.
ADH is synthesized in the hypothalamus and transported to the posterior pituitary. ADH is then released into the circulatory system and carried to the primary target tissue in the kidney. ADH promotes water retention and reduces urine volume.
Thyroid hormones are transported in the blood in combination with plasma proteins. Approx. 70-75% of T3 & T4 are bound to thyroxinbinding globulin (TBG). 20-30% are bound to other plasma proteins. Therefore, high half-life.
Thyroid hormones diffuse through the target cell membrane. Bind to receptors in the nucleus. Thyroid hormones affect nearly every tissue in the body. Factors such as metabolism, growth, and maturation are affected.
Located atop the kidneys. Composed of an inner medulla and an outer cortex.
All hormones are steroids. Lipid soluble and are carried in the plasma by protein carriers. Three hormone types:
Mineralocorticoids (e.g. aldosterone) Glucocorticoids (e.g. cortisol) Androgens
Adrenocorticotropin-releasing hormone (ACTH) is necessary to maintain the sensory activity of the adrenal cortex. Corticotropin-releasing hormone (CRH) is released from the hypothalamus and stimulates the anterior pituitary to secrete ACTH.
Table 18.9 outlines the abnormalities associated with hypersecretion and hyposecretion of adrenal hormones.
Table 18.9 outlines the abnormalities associated with hypersecretion and hyposecretion of adrenal hormones. Predict 7
Predict 7
Cortisone, a drug similar to cortisol, is sometimes given to people who have severe allergies or extensive inflammation or who suffer from autoimmune diseases. Taking this substance chronically can damage the adrenal cortex. Explain how this damage can occur.
Table 18.9 outlines the abnormalities associated with hypersecretion and hyposecretion of adrenal hormones. Predict 7 Clinical Focus Stress (page 621; 633)
Effects of Aging
What happens to the endocrine system when we get old? Endocrine glands differ in how they respond to the aging process. Some experience a gradual decrease in secretion while others are not affected to a great degree.
Effects of Aging - Growth Hormone There is a decrease in growth hormone (GH). Decrease is greater in people who do not exercise. Decreases in GH may explain a gradual decrease in lean-body mass in these people.
Effects of Aging - Melatonin Melatonin decreases in aging people. May influence sleeping patterns. May also affect the patterns of other hormones like GH and testosterone.
Effects of Aging - Thyroid Hormone Decreases slightly with increasing age. Age-related damage to the thyroid gland may also occur.
Effects of Aging - Insulin There does not appear to be a age-related decrease in the ability to maintain blood glucose levels. However, there is an age-related tendency to develop Type II diabetes.
Hormonelike Substances
Autocrine chemical signals are released from cells in a local area and influence activity of the same cell type. Paracrine chemical signals are produced by a wide variety of tissues and secreted into tissue spaces.
Hormonelike Substances
Autocrine and paracrine signals are not like hormone signals. They are not secreted by endocrine glands. They act locally not systemically. They are also not completely understood
These products are released from injured cells. Responsible for initiating some of the symptoms of inflammation. Pain receptors are stimulated directly by prostaglandins.
Prostaglandins
Produced in all cells in the body except for red blood cells. Once prostaglandins enter the circulatory system, they are metabolized rapidly. They are synthesized from essential fatty acids (omega-3, omega-6). Ratio of omega-6:omega-3 seems to be important in the synthesis of prostaglandins.
Prostaglandins
Anti-inflammatory drugs like asprin inhibit prostaglandin synthesis. Prostaglandins can both intensify or diminish inflammation and increase or decrease the clotting tendency of the blood. In order for the body to remain healthy, these two potentials must be properly balanced.
Prostaglandins
In simple terms; prostaglandins derived from omega-6 fatty acids promote inflammation and blood clotting, while those derived from omega-3 fatty acids oppose those effects. Remember that both are needed to maintain health.
Prostaglandins
Evidence suggests that our diet can affect this balance. The Western diet is deficient in omega-3 fatty acids. An ideal omega-6:omega-3 ratio is between 1:1 and 4:1. A typical American diet is between 20:1 and 40:1!
Prostaglandins
Essential fatty acid deficiency and omega6:omega-3 imbalance is linked with the following serious health conditions:
Heart attack Lupus Obesity Cancer Insulin resistance Schizophrenia Depression Diabetes Arthritis Asthma Stroke Alzheimers Disease
Prostaglandins
Omega-3 sources:
Flaxseed oil Fish oil Flax seeds, hemp seeds Walnuts, walnut oil Salmon, herring, mackerel, sardines Soybeans, soybean oil
Prostaglandins
Omega-6 sources:
Corn oil Peanut oil Meat Poultry Safflower oil Sesame oil Sunflower oil