Endometrial Cancer

By REBORN Faculty of Medicine UNTAN

The Points of Explanation

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3. 4. 5. 6. 7. 8. 9.

Definition of uterine Definition of endometrial cancer Cause and risk factors of endometrial cancer Stages of endometrial cancer The symptoms of endometrial cancer The diagnosis of endometrial cancer The treatment of endometrial cancer The side effects of endometrial cancer treatment The prevention of endometrial cancer

What Is Uterine?
Uterine is genitalia organ that consist of: body of uterine (corpus uteri), neck of uterine (canalis servicalis), mouth of uterine (cervic).

Anatomy of the Uterus

What Is Endometrial Cancer?

There are two types of uterine cancer, that are: 1. Endometrial cancer 2. Leiomiosarkoma Endometrial cancer is carcinoma of the lining of the uterus - is the most common gynecologic malignancy

Normal Uterus

Endometrial Cancer

Causes and Risk Factors of Endometrial Cancer

1. Estrogen hormone women ovum is not produced estrogen is produced overly thickening of endometrium cancerous cells

2. Obesity

obesity
fat

estrogen also be produced in fat

thickening of endometrium cancerous cell 3. Diabetes Melitus

4. Hypertension 5. Nulliparity, is women uncapability to get

birth a child that can live

6. Environment factor and diet 7. Genetic factor

Endometrial Cancer Staged

Stage I Stage II Stage III Stage IV

STAGE I
In stage I, cancer is found in the uterine fundus. Stage I is divided into stages IA, IB, and IC.

Stage IA

Stage IA: Cancer is in the endometrium only.

Stage IB

Stage IB: Cancer has spread into the inner half of the myometrium

Stage IC

Stage IC: Cancer has spread into the outer half of the myometrium.

Stage II
In stage II, cancer has spread from the uterus to the cervix, but has not spread outside the uterus. Stage II is divided into stages IIA and IIB:

Stage IIA

Stage IIA: Cancer has spread to the glands where the cervix and uterus meet.

Stage IIB

Stage IIB: Cancer has spread into the connective tissue of the cervix.

STAGE III
In stage III, cancer has spread beyond the uterus and cervix, but has not spread beyond the pelvis.

Stage IIIA

Stage IIIA: The cancer has spread to the serosa of the uterus or to the adnexa, or there are cancer cells in peritoneal fluid. The cancer has not spread to lymph nodes or distant sites

Stage IIIB

Stage IIIB: The cancer has spread to the vagina. The cancer has not spread to lymph nodes or distant sites.

Stage IIIC
Stage IIIC: The cancer can be any size, but has spread to lymph nodes near the uterus but not to distant sites.

STAGE IV
The cancer has spread to the mucosa of the urinary bladder or the rectum and/or has spread to lymph nodes in the groin, and/or has spread to distant organs.

Stage IVA and Stage IVB

Stage IVA Stage IVB

What are the Symptoms of Endometrial Cancer?

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Pain or a feeling of fullness in the pelvis area or lower abdomen Bleeding or dishcharge not related to menstruation (periods) Difficult or painful urination Pain during sexual intercourse Pain in the pelvic area Abnormal condition of menstruation that are, so much and so long

The Diagnosis of Endometrial Cancer

Complaint of Patient Pap test

Endometrium Biopsy
Dilation & Curretage Transvaginal Ultrasound

Pap Test
uterus

vagina

Take sample of cells from cervic

cervix

Sample of cells

Endometrium Biopsy

Dilation and Curretage

1 1 2

Tissue from the Uterine lining is scrapped and examined under a microscope for Cancer cells

Transvaginal Ultrasound
The goal is look for abnormalities in your uterine lining

TREATMENT

Based on the stage and the grade of the cancer The standard therapy is an abdominal hysterectomy Obtaining a specimen from the cancer for analysis of its estrogen and progesterone Radiation therapy Surgical operation to ovarium and uterus Chemotheraphy.

Side Effect of the Treatment

Anemia Anxiety and depression Appetite changes Bleeding Constipation Diarrhea Hair losses Insomnia

The Prevention of Endometrial Cancer

Primary prevention: Avoid the risk factors of endometrial cancer Secondary prevention: Clinic inspection through USG and endometrial citology inspection.

Thanks..