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MAIN OBJECTIVE To illustrate the renal response to fluid deprivation,water loading and isosmotic fluid expansion
To determine urine volume, flow rate, specific gravity and sodium concentration on all urine samples
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A.urine sample was collected and Discarded. Time of collection was noted
RATIONALE: This is done to ensure that the following urine samples are not contaminated by previous water or food intake
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B. First urine sample was taken which was labeled PRE INGESTION.
The sample was analyzed for: Volume and Flow Rate Specific Gravity Sodium Concentration RATIONALE: this specimen serves
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C.Immediately after the collection ,the subject rapidly drinks either: Glucose Water 0.9% NaCl None
RATIONALE The ingestion of fluid serve as INTERVENTION. Glucose,water and 0.9% Isotonic NaCl have different tonicities that would alter urine volume and sodium concentration
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This was subjected to specific gravity Urine volume Flow rate An aliquot of urine was prepared for Na concentration using the
It is the volume of plasma passing through the kidneys that has been totally 8 cleared of a solute
Inulin
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to Measure GFR
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Urine Flow Rate per minute (ml/min) Clearance (mL/min) Urine Plasma concentration of a concentration of a substance substance (mg/ml) 13 (mg/ml)
Renal Clearance =
For a given plasma Concentration, renal clearance of a substance increases as the urinary excretion increases.
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INULIN
Ideal substance that measure GFR Not clinically used Intravenous
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CREATININE
Used Clinically Endogenous End product of muscle metabolism 10 % Secreted in the Proximal Tubule Amount filtered=amount excreted
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Discuss the physiologic basis for the mathematical formula used for the computation of the creatinine clearance
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FICKS PRINCIPLE
Pxa
INPUT
OUTPUT
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VOLUME OF PLASMA FROM WHICH ALL THE CREATININE HAS BEEN REMOVED AND EXCRETED INTO THE URINE PER UNIT TIME.
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What is the relationship between Creatinine Clearance and Glomerular Filtration Rate GFR?
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GFR
Creatinine Clearance Describes how many Describes how many milliliters of Plasma milliliters of plasma passing into the passing through the Bowman capsule per kidneys that have unit time been totally cleared of a solute in a given Inulin Clearance is period of time accurate but expensive Overestimates GFR but is inexpensive
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