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DR I. K. OWUSU
What is Shock?
Shock is a physiologic state characterized by
perfusion, resulting in decreased oxygen delivery to the tissues. This creates an imbalance between oxygen delivery and oxygen consumption. Prolonged oxygen deprivation leads to cellular hypoxia and derangement of critical biochemical processes at the cellular level, which can progress to the systemic level and if untreated, to death.
low (eg cardiogenic shock) The common factor is failure of tissue oxygen delivery and/or utilisation
Epidemiology
Mortality
Effects of Shock
Cellular effects include cell
membrane ion pump dysfunction, intracellular edema, leakage of intracellular contents into the extracellular space, and inadequate regulation of intracellular pH Systemic effects include alterations in the serum pH, endothelial dysfunction, and stimulation of
Effects of Shock
contd
reversible, but rapidly become irreversible. The result is sequential cell death, end-organ damage, multi-system organ failure, and death. This highlights the importance of prompt recognition and reversal of shock
fluid leading to circulatory instability: Heamorrhage may be internal eg upper GIT bleeding, ruptured anuerysm or external .eg bleeding from laceration Fluid loss - e.g. diarrhea, vomiting, burns, third spacing, iatrogenic
Hypovolemic Shock
Hemorrhagic Shock
Parameter Blood loss (ml) Blood loss (%) I <750 <15% II 7501500 1530% III 15002000 3040% IV >2000 >40%
<100 Normal
>100 Decreased
>120 Decreased
>140 Decreased
1420
2030
3040
>35
>30 Normal
2030 Anxious
515 Confused
Negligible Lethargic
infection from certain bacteria that release a chemical mediators which affects the proper functioning of the blood vessels. Vascular tone is reduced leading to vasodilatation and pooling of blood into the vascular system.
there is sudden release of histamine and other chemical mediators in response to injection of a particular foreign substance, as in the case of an insect sting or certain medications. This leads to reduction in vascular tone, vasodilatation and pooling of
Cardiogenic Shock
This results from any circumstance that severely
Arrythmia
Pulmonary embolism Pericardial tamponade Cardio-depressant drugs (drugs with negative
Neurogenic shock
Manifested by fainting ,
occurs when the regulating capacity of the nervous system is impaired by severe pain, profound fright, or other overwhelming stimulus.
Clinical presentation
Depends upon the severity and speed of onset of
cause and the physiologic reserve of the host Systolic BP < 90 mmHg with features of reduced organ perfusion.
Clinical Presentation
Clinical presentation varies with type and cause,
but there are features in common Hypotension (SBP<90 mmHg) Tachycardia Tachypnea Cool, clammy skin (exceptions early septic shock, terminal shock) Oliguria Change in mental status Metabolic acidosis
Assessment
Should be rapid
relatives
Check immediately
Airway competence
Breathing
Circulation-pulse rate, rhythm, volume &
character
Specifically examine
Peripheral perfusion, including capillary refill
Blood pressure
JVP Check the trachea The Chest Conscious level Blood sugar
Chest X-ray
Arterial blood gas analysis Urgent biochemistry: BUE, glucose, Calcium FBC If sepsis is suspected, blood C/S
Treatment
Manage the emergency Determine the underlying cause Definitive management or support
and refer to Cardiologist for a possible pacing If the patient is not in cardiogenic shock, Give rapid IV fluid challenge (eg normal saline) If the BP remains low (<70 mmHg) despite adequate filling and treatment of immediate reversible causes, obtain central venous access start ionotropes (eg Dobutamine) Call your resident/specialist/consultant
Definitive Management
Hypovolemic Fluid resuscitate (blood or
crystalloid) and control ongoing loss Cardiogenic - Restore blood pressure (chemical and mechanical) and prevent ongoing cardiac death Vasodilatory/Dilatstributive Fluid resuscitate, pressors for maintenance, immediate antibiotic control for infection, etc.