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The Science
arrest % Surviving
CPR defibrillation
ROSC
CPR is over 50 years old, but recent changes have shown increases in survival
1961
Not the pH Not the oxygen content Its all about Coronary Perfusion Pressure !
24-hour Survivors
Kern, Ewy, Voorhees, Babbs, Tacker Resuscitation 1988; 16: 241-250 Paradis et al. JAMA 1990; 263:1106
n=1626 segments
250 200
150
100 50 0
10-20 20-30 30-40 40-50 50-60 60-70 70-80 80-90 90-100 100-110 110-120 R>120
180 150
120
No ROSC ROSC
90
60
30 0 10-20 20-30 30-40 40-50 50-60 60-70 70-80 80-90 90-100 100-110 110-120 >120
CPP, mm Hg
32
Survival: 100%
24
16
8
0
p=0.02
n=10
n=13
n=14
n=5
Ensure Total Chest Recoil with: 1) Lifting palm during compressions or 2) Using feedback device
Examples: Devices providing real-time feedback are available from several manufacturers
16 seconds
Single rescuer performing 30:2 with realistic 16 sec. interruption of chest compressions for MTM ventilations
160 Cerebral Perfusion Pressures No Cerebral Perfusion 5 sec 120 mmHg
80
Time (sec)
120 mmHg
80
CPR before defibrillation may increase survival (when CA not witnessed by EMS)
Influence of cardiopulmonary resuscitation prior to defibrillation in patients with out-of-hospital ventricular fibrillation
24% (155/639)
Defib first
42 months
30% (142/478)
36 months
p=0.04
probability of survival
p=0.006
10
12
14
4:55
ECG
5:00
5:05
5:10
Compressions
90%
p=0.003
64% 55%
10%
33.2 (n=10)
Valenzuela et al, Circ 2005 Wik et al, JAMA 2005 Abella et al, JAMA 2005 Aufderheide et al,Circ 2004
3. Minimize ventilations (8-10 bpm) 4. Use capnography & debriefing, consider CPR feedback tools 5. Ensure access to hypothermia and cardiac catheterization
The Metabolic Phase (~>10 minutes) Survival decreased Science searching for more successful treatments
2010
Bystander contacted 9-1-1
11.5% Survival to DC
14.4%
(OR 2.9)
CPR (2010) emphasizes: Circulation Airway Breathing CCR (Cardiocerebral Resuscitation) emphasizes: Circulation (uninterrupted compressions) Deemphasizes ventilation
Tucson version (2003) Cardiocerebral Resuscitation (Intubation delayed; Bag Valve Mask ventilation)
Analysis
Analysis
Analysis
If adequate bystander chest compressions are provided, EMS providers perform immediate rhythm analysis and shock if indicated
Survival after Bystander CPR for OHCA in Arizona (2005 to 2010) Compression Only CPR Advocated and Taught Survival to Hospital Discharge
35%
30% 25%
A. All OHCA
AOR 1.6 (95% CI, 1.08-2.35)
B. Witnessed/Shockable
P < 0.001
20%
15% 10%
33.7%
5%
0%
7.8%
Std-CPR
13.3%
COCPR
17.7%
Std-CPR COCPR
50%
40% 30% 20% 10% 0%
Rock and Walworth
Annals Emergency Med 2008
35/89 34/136
39/102
75/192
39%
38%
38%
Arizona
K.C. MO
Circulation 2009
2009
Randomized trial of EPINEPHrine versus no EPINEPHrine For EMS treated cardiac arrest NO BENEFIT IN SURVIVAL TO DISCHARGE FROM HOSPITAL!
Dont be fooled by agonal respirations Cycles of 200 uninterrupted compressions Early defib if good bystander CPR or EMS witnessed arrest
331A
4 cycles of 200 compressions/ defib Compressions cause passive ventilation Medical director sets airway/ ventilation options
331A
After 4 cycles of 200 uninterrupted compressions, add ventilations at 15:1 Indications for possible BLS field termination of CPR Arrest not witnessed by EMS, AND No ROSC/pulse prior to transport, AND No AED shock delivered prior to transport
3031A
EPINEPHrine every 3-5 minutes Antidysrhythmic if 2nd shock needed Medical director sets airway/ventilation options for agency Monitor capnography Avoid intubation during initial cycles of compressions
3031A
3031A
Treat reversible causes
Pneumothorax Hypovolemia
Appropriate medication
Antidysrhythmic Mg for torsades (rare) Calcium/bicarbonate in dialysis
Creates, implements and revises an action plan Communicates accurately and concisely while listening and encouraging feedback Receives, processes, verifies, and prioritizes information Reconciles incongruent information Demonstrates confidence, compassion, maturity, (respect for team members), and command presence Takes charge Maintains accountability for teams actions/outcomes Assesses situation and resources and modifies accordingly
Role of medications
Epinephrine (IIb)
Ideally within first minute
Antidysrhythmic (IIb)
For refractory VF/VT
Post-code
Debriefing QI Review Benchmarking (Cardiac Arrest Registry for Enhanced Survival CARES)
Role of Checklist Designed for Efficiency/ Uniformity Evidence-based Perfect practice makes perfect
Initial training/ Simulation Regular practice/ Simulation
Must Measure Outcomes PDSA Cycle (Continuous Improvement) Plan Do Study Act Small Tests of Change
Conclusion
Improved Dispatch/Bystander CPR High-quality uninterrupted compressions NASCAR Pit Crew Approach to Cardiac Arrest Transport to hypothermia/PPCI Center QI Measure Our Outcomes Celebrate Our Success !!
Thank You! Dr. Gordon Ewy (Univ. of Arizona) Dr. Benjamin Abella (Univ. of Pennsylvania) for providing several slides to this presentation