INTRODUCTION TO THE ENDOCRINE SYSTEM

Prof. Dr. Ieva B Akbar, dr., AIF.

Hormone
Hormone Have Been !no"n S#n$e An$#en% %#me &'a% Make a C'em#$a( a Hormone) Hormone Are Se$re%ed b* a Ce(( or +ro,- of Ce(( Hormone Are Se$re%ed #n %o %'e B(ood Hormone Are Tran -or%ed %o a D# %an% Tar.e% Hormone A$% b* B#nd#n. %o Re$e-%or Hormone A$%#on M, % Be Term#na%ed

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#f#$a%#on Of Hormone

Mo % Hormone Are Pe-%#de or Pro%e#n Pe-%#de Hormone S*n%'e # , S%ora.e, and Re(ea e Po %/Tran (a%#ona( Mod#f#$a%#on of Pro'ormone Tran -or% #n %'e B(ood and Ha(f/0#fe of Pe-%#de Ce((,(ar Me$'an# m of A$%#on of Pe-%#de Hormone S%ero#d Hormone Are Der#ved from C'o(e %ero( S%ero#d Hormone S*n%'e # and Re(ea e Tran -or% #n %'e B(ood and Ha(f/0#fe of S%ero#d Hormone Ce((,(ar Me$'an# m of A$%#on of S%ero#d Hormone Am#ne Hormone Are Der#ved from One of T"o Am#no A$#d

Con%ro( Of Hormone Re(ea e

Hormone Can Be C(a #f#ed b* T'e#r Ref(e1 Pa%'"a* T'e Endo$r#ne Ce(( I %'e Sen or #n %'e S#m-(e % Endo$r#ne Ref(e1e Man* Endo$r#ne Ref(e1e Invo(ve %'e Nervo, S* %em Ne,ro'ormone Are Se$re%ed #n%o %'e B(ood b* Ne,ron T'e P#%,#%ar* +(and # A$%,a((* T"o F, ed +(and T'e Po %er#or P#%,#%ar* S%ore and Re(ea e T"o Ne,ro'ormone T'e An%er#or P#%,#%ar* Se$re%e S#1 Hormone Feedba$k 0oo- Are D#fferen% #n %'e H*-o%'a(am#$/P#%,#%ar* Pa%'"a* T'e H*-o%'a(am#$/H*-o-'* ea( Por%a( S* %em D#re$% Tro-'#$ Hormone De(#ver* An%er#or P#%,#%ar* Hormone Con%ro( +ro"%', Me%abo(# m, and Re-rod,$%#on

Hormone In%era$%#on
In S*ner.# m, %'e Effe$% of In%era$%#n. Hormone I More T'an Add#%#ve A Perm# #ve Hormone A((o" Ano%'er Hormone %o E1er% I% F,(( Effe$% An%a.on# %#$ Hormone Have O--o #n. Effe$%

Endo$r#ne Pa%'o(o.#e
H*-er e$re%#on E1a..era%e a Hormone2 Effe$% H*-o e$re%#on D#m#n# 'e or E(#m#na%e a Hormone2 Effe$% Re$e-%or or Se$ond Me en.er Prob(em Ca, e Abnorma( T# ,e Re -on #vene Do"n/Re.,(a%#on Re$e-%or an S#.na( Tran d,$%#on Abnorma(#%#e D#a.no # of Endo$r#ne Pa%'o(o.#e De-end on %'e Com-(e1#%* of %'e Ref(e1

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