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Cardiac
Protection
By CJ Lau
15 July 2009
What are dietary
supplements?
a product (other than tobacco) that is
intended to supplement the diet which
contains one or more of the following dietary
ingredients: a vitamin, a mineral, a herb or
other botanical, an amino acid, a dietary
substance for use by man to supplement the
diet. It is intended for ingestion in pill,
capsule, tablet or liquid form, and should not
be used to replace a meal or diet.
In UK, the definition includes substances
such as garlic, ginseng, psyllium, enzymes,
fish oil and other ingredients.
Cardiac Protection
Supplements
Outline
Coenzyme Q10
Fish Oil
L- Carnitine
Antioxidant
Folic acid
Coenzyme Q10
(Ubiquinone)
Is a naturally occurring enzyme cofactor found in the
mitochondria of the body cells.
It is involved in electron transport and supports the
synthesis of adenosine triphosphate (ATP) in the
mitochondrial membrane
It is a fat-soluble antioxidant that helps to stabilise cell
membranes, preserving cellular integrity and function
It may be obtained from the diet or a food supplement,
but it is also produced endogenously
Coenzyme Q10
Meat and fatty fish products are the most
concentrated sources
smaller quantities are found in wholegrain
cereals, soya beans, nuts and vegetables,
particularly spinach and broccoli
no Dietary Reference Values or RDAs
have been established as it is not an
essential nutrient
Deficiency has been linked to chronic
heart failure, ischemic heart disease,
cardiomyopathy and hypertension
Coenzyme Q10
Coenzyme Q10 is sold in capsules and tablets in
strengths of 10–150 mg.
Doses used in studies investigating CVD have ranged
from 100 to 150 mg daily. Higher doses have been
used in angina (150–600 mg daily).
Safety in pregnancy has not been established.
Coenzyme Q10 seems to be safe and relatively well
tolerated in doses of up to 10–200 mg daily. There are
occasional reports of gastrointestinal discomfort,
dizziness and skin rash, but these tend to occur with
doses > 200 mg daily.
Drug Interaction