Learning objective: to examine what enzymes are and
describe how they work. 16 th October Enzymes What are they? Why do we need them? Name some examples ? Enzymes Globular proteins that catalyse chemical reactions in living organisms Properties Enzymes Globular proteins that catalyse chemical reactions in living organisms Properties Specific Enzymes Globular proteins that catalyse chemical reactions in living organisms Properties Specific Increase rate of the reaction Enzymes Globular proteins that catalyse chemical reactions in living organisms Properties Specific Increase rate of the reaction Unchanged at the end of the reaction Enzymes Globular proteins that catalyse chemical reactions in living organisms Properties Specific Increase rate of the reaction Unchanged at the end of the reaction Need them Enzymes Globular proteins that catalyse chemical reactions in living organisms Properties Specific Increase rate of the reaction Unchanged at the end of the reaction Need them Reactions too slow to maintain life Cant increase temperatures/pressure in cells (fatal) Enzymes Are Proteins The enzyme binds to the substrates by its active site
The active site is a pocket formed by the folding of the protein where the substrates bind. Enzymes Are Proteins The enzyme binds to the substrates by its active site
The active site is a pocket formed by the folding of the protein where the substrates bind. Active site The active site involves a small number of key residues that actually bind the substrates
The rest of the protein structure is needed to maintain these residues in position How do enzymes work? An Example An Example Sucrose + H 2 O Glucose + Fructose An Example Sucrose + H 2 O Glucose + Fructose Substrates Products For a reaction to occur the sucrose and water would have to collide with enough energy to break and form bonds For a reaction to occur the sucrose and water would have to collide with enough energy to break and form bonds
This is the activation energy Sucrose + H 2 O Glucose + Fructose + + Substrates Products Energy Progress of reaction Energy Progress of reaction Substrates Energy Progress of reaction Substrates Products Energy Progress of reaction Substrates Products High energy intermediate Energy Progress of reaction Substrates Products High energy intermediate Activation energy The minimum amount of energy needed to start the reaction, leading to the formation of a high energy intermediate
= The Activation energy Energy Progress of reaction Substrates Products High energy intermediate Activation energy Enzymes reduce the height of the energy barrier Questions 1. Write a definition for the following: Active Site Substrate Products
2. Explain how the structure of the protein is linked to its ability to act as an enzyme?
3. How does heating a mixture increase the chance that a chemical reaction Will occur? Why cant this approach be used in cells?
4. Write a paragraph in your own words describing how enzymes act as catalysts by lowering activation energy. Read page 57-60 This powerpoint was kindly donated to www.worldofteaching.com
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