THE DIGESTIVE SYSTEM FUNCTION OF THE DIGESTIVE SYSTEM 1. Ingestion Introduction of solid or liquid food into the stomach 2. Mastication The process by which food taken into the mouth is chewed by the teeth 3. Propulsion The movement of food from one end of the digestive tract to the other 4. Mixing Some contraction move the food back and forth within the digestive tract to mix it with digestives secretion and to help break into smaller pieces Function of .. 5. Secretion As food moves through the digestive tract, secretion are added to lubricate, liquefy, and digest the food 6. Digestion The breakdown of large organic molecules into their components parts 7. Absorption The movement of molecules out of the digestive tract and into the circulation or into the lymphatic system 8. Elimination The process by which the waste products of digestion are removed from the body REGULATION OF THE DIGESTIVE SYSTEM 1. Nervous Regulation Local, within the Enteric Nervous System (ENS) a. Enteric sensory neuron, detect chemical composition and mechanical changes b. Enteric motor neuron, stimulate or inhibit smooth muscle contraction and glandular secretion c. Enteric inter-neuron, connect the sensory and motor neuron d. Coordinate local reflexes General, through the Vagus nerve Control the reflexes activated by stimuli from the digestive tract, sight, smell, taste which stimulate the hunger sensation Parasymphathetic neuron excitation muscle contractin and blood supply Sympathetic neuron inhibit muscle contraction and blood supply. Regulation .. 2. Chemical Regulation GIT produce hormones: gastrin, secretin, etc. regulate other secretion Histamine (Paracrine chemicals) influence the nearby cells Oral Cavity .. Assignment 1. List the major regions og the digestive tract 2. Describe each of the processes involved in the normal functions of the digestive system 3. Outline the basic histological characteristic of the digestive tract 4. Describe the enteric plexus. In what layer of the digestive tract are the submucosal and myenteric plexuses found? 5. What are the nervous and chemical mechanism that regulate the digestive system? Oral cavity 1. Lips and Cheeks Help manipulate food within the mouth and hold it in place while teeth crush or tear it 2. Palate and Palatine Tonsils Prevents food from passing into the nasal cavity 3. Tongue Contain sensory organs for taste Moves food in the mouth, holds the food in place during mastication 4. Teeth Play an important role in mastication and speech The anterior are incisors, canines to cut and tear, premolars and molars crush and grind food 5. Mastication .. 5. Mastication Food taken into the mouth is chewed or masticated by the teeth Food are broken into smaller particles have larger total surface area efficiency of digestion Is reflex, which integrated in the medulla oblongata. Food stimulate sensory receptor activate reflex (muscle of mastication relax). The muscle are stretched as the mandible lowered, stretch activate reflex contraction of the mastication muscles. Once the mouth is closed, the food again stimulate reflex to relax the muscle, and the cycle is repeated. Cerebrum strongly influence the activity of mastication initiated and stopped consciously. Cerebrum control the intensity and movement 6. Salivary Gland Secretes saliva 1 1.5 L/day, contain salivary amylase. Breaks starch and polysaccharides maltose and isomaltose (sweet taste) Digest 3 5% carbohydrate (food spends very little time in the mouth) Saliva contain lysozyme prevent bacterial infection Assignment 1. What are the function of the lips and cheeks? What muscle forms the substance of the cheek? 2. List the functions of the tongue. Distinguish between intrinsic and extrinsic tongue muscles 3. List the muscle of mastication and actions they produces. Describe the mastication reflex 4. Explain the function of saliva PHARYNX The main function: transmit food 1. Nasopharynx 2. Oropharynx 3. Laryngopharynx Esophagus Extends between pharynx and the stomach, 25 cm long, lies in the mediastinum anterior to the vertebrae and posterior to trachea Transports food from pharynx to the stomach The upper esophageal sphincter and lower esophageal sphincter regulate the movement of material into and out the esophagus Numerous mucus gland produce a thick, lubricating mucus, facilitate the movement of material Swallowing (deglutition) Three phases: 1. Voluntary phase 2. Pharyngeal phase (a reflex) 3. Esophageal phase Voluntary phase Reflex Begin Bolus stimulates tactile receptors Pharyngeal phase (reflex) Tactile receptors N. V and IX Med. Oblongata N. V, IX, X, XI Soft palate elevates closes the passage between nasopharynx and oropharynx. The pharynx elevate and move the bolus Esophageal phase Inferior constrictor contract upper esophageal sphincter relax bolus enter the esophagus The bolus moves along esophagus by peristaltic Assignment 1. What are the three phases of deglutition? 2. List the processes involved in the last two phases, and describe how they are regulated? Stomach Anatomy of the stomach Extends from the opening of gastroesophageal to pyloric Histology of the stomach The wall consists of serosa, muscle layer, submucosa, simple columnar epithelium Rugae are the fold in the stomach when it is empty Gastric pits are the opening to the gastric gland contain mucous neck cells, chief cells, and endocrine cell Stomach .. Stomach Function Secretion of the Stomach 1. Mucus protects the stomach lining 2. Pepsinogen is converted to pepsin digest protein 3. HCl promote pepsin activity and kill microorganism 4. Intrinsic factor is necessary for absorption of vitamin B 12 5. The sight, smell, taste, or thought of food initiate cephalic phase. Nerve impulses from medulla stimulate HCl, pepsinogen, gastrin, and histamine secretion 6. Distention of stomach, which stimulate gastrin secretion and activates CNS and local reflexes that promote secretion, initiate gastric phase 7. Acidic chyme, which enters the duodenum and stimulate neuronal reflexes and secretion of hormones that inhibit gastric secretion, initiate the intestinal phase Stomach function HCl Production by Parietal Cells in the Gastric Glands of the Stomach The Cephalic Phase of Gastric Secretion REGULATION OF GASTRIC SECRETION The Gastric Phase of Gastric Secretion The Intestinal Phase of gastric Secretion Movement of the Stomach 1. The stomach stretches and relaxes to increase volume 2. Mixing waves mix the stomach contents with stomach secretion to form chyme 3. Peristaltic waves move the chyme into duodenum MOVEMENT OF THE STOMACH MOVEMENT OF THE STOMACH Stomach Emptying 1. The pyloric pump responsible for movement of chyme through the pyloric opening 2. Gastrin and stretching of the stomach stimulate stomach emptying 3. Chyme entering duodenum inhibit movement through the neural reflexes and the release of hormones
Assignment 1. Describe the parts of the stomach. List the layers of the stomach wall. How is the stomach different from the esophagus? 2. What are gastric pits and gastric glands? Name the different cell types in the stomach and the secretions they produce 3. Describe the three phases of regulation of the stomach scretion, and discuss the cause and result of each phase 4. How are gastric secretions inhibited? Why is this inhibition necessary? 5. Why does pressure in the stomach not greatly increase as the stomach fills? 6. What are two kinds of stomach movements? How are stomach movements regulated by hormones and nervous control? SMALL INTESTINE Divided into duodenum, jejunum, and ileum Its wall consists of external serosa, muscles (longitudinal and circular), submucosa, and simple columnar epithelium Circular fold, villi, and microvilli greatly increase the surface area of the intestinal lining Absorptive, goblet, and endocrine cells are in intestinal glands. Duodenal glands produce mucus Small intestine .. Secretion of the small intestine 1. Mucus protect against digestive enzymes and stomach acids 2. Digestive enzyme (disaccharidases and peptidases) are bound to intestinal wall 3. Chemical or tactile irritation, vagal stimulation, and secretin stimulate intestinal secretion Movement of the small intestine Segmental contraction mix intestinal contents. Peristaltic contraction move materials distally Stretch of smooth muscle, local reflexes, and the parasympathetic nervous system stimulate contractions. Distention of the cecum initiates a reflex that inhibit peristalsis Assignment 1. What are the function of the intestinal glands and duodenal glands? State the factors that stimulate secretion from the duodenal glands and from goblets cells. 2. List the enzymes of the small intestine wall and give their functions 3. What are the two kinds of movement of the small intestine? How are they regulated? 4. What is the function of the ileocecal sphincter? LIVER The functions of the liver 1. The liver produces bile, which contains bile salts that emulsify fats. Secretin increase bile production Function of the liver .. The function of the liver (continue) 2. The liver stores and processes nutrients, produces new molecules, and detoxifies molecules The function of the liver .. 3. Hepatic phagocytic cells phagocytize red blood cells, bacteria, and other debris 4. The liver produces blood components Control of Bile Secretion and Release GALLBLADDER 1. The gallbladder is a small sac on the inferior surface of the liver 2. The gallbladder stores and concentrates bile 3. Cholecystokinin stimulates gallbladder contraction PANCREAS 1. The pancreas is an endocrine and exocrine gland. Its exocrine function is the production of the digestive enzymes 2. The pancreas is divided into lobules that contain acini. The acini connect to a duct system the eventually forms the pancreatic duct, which empties into duodenum 3. Secretin stimulates the release of a watery bicarbonate solution that neutralize acidic chyme 4. Cholecystokinin and vagus nerve stimulate the release of digestive enzymes Bicarbonate ion production in the pancreas Control of Pancreatic secretion Assignment 1. Explain and give examples of the major functions of the liver 2. What stimulates bile secretion from the liver 3. What is the function of the gallbladder? What stimulates the release of bile from the gallbladder? 4. Describe the part of the pancreas responsible for endocrine and exocrine secretions. Diagram the duct system of the pancreas 5. Name the two kinds of exocrine secretions produced by the pancreas. What stimulates their production and what is their function? 6. What are the enzyme present in the pancratic juice? Explain the function of each. LARGE INTESTINE Secretion of large intestine 1. Mucus provides protection to the intestine lining 2. Epithelial cells secrete bicarbonate ions. Sodium is absorbed by active transport, and water is absorbed by osmosis 3. Microorganism are responsible for vitamin K production, gas production, and much of the bulk of feces Large intestine . Movement in the large intestine 1. Segmental movement mix the colons contents 2. Mass movement are strong peristaltic contraction that occur three to four time a day Large intestine . 3. Defecation is the elimination of feces. Reflex activity moves feces through the internal anal sphincter. Voluntary activity regulates movement through the external anal sphincter Reflexes in Colon and Rectum Assignment 1. Describe the part of the large intestine. What are teniae coli, haustra, and crypts 2. Explain the difference in structure between the internal anal sphincter and the external anal sphincter 3. Name the substances secreted and absorbed by the large intestine. What is the role of microorganism in the colon? 4. What kind of movement occur in the colon? Describe the defecation reflex. DIGESTION, ABSORPTION, and TRANSPORT 1. Digestion is the breakdown of organic molecules into their component parts 2. Absorption and transport are the mean by which molecules are moved from the lumen into the circulation 3. Transportation occurs by two different routes. Water, ions, and water-soluble products of digestion are transported to the liver through the hepatic portal system The product of lipid digestion are transported through the lymphatic system to the circulatory system CARBOHYDRATES 1. Carbohydrates consist starches, glycogen, sucrose, lactose, glucose, and fructose 2. Polysaccharides are broken down into monosaccharides by a number of different enzymes 3. Monosaccharides are take up by intestinal epithelial cells by active transport or by facilitated diffusion 4. Monosaccharides are carried to the liver where the nonglucose sugars are converted to glucose 5. Glucose is transported to the cells that require energy 6. Glucose enters the cells through facilitated diffusion 7. Insulin influences the rate of glucose transport Monosaccharide Transport LIPIDS 1. Lipids include triglycerides, phospholipids, steroids, and fat-soluble vitamins 2. Emulsification is the transformation of large lipid droplets into smaller droplets and is accomplished by bile salts 3. Lipase digest lipid molecules to form free fatty acids and glycerol 4. Micelles form around lipid digestion products and move to epithelial cells of small intestine, where the products pass into the cells by simple diffusion 5. Within the epithelial cells, free fatty acids are combined with glycerol to form triglyceride Lipids .. 6. Proteins coat triglycerides, phospholipids, and cholesterol to form chylomicrons 7. Chylomicrons enter the lacteals within the intestinal villi and are carried through the lymphatic system to the bloodstream 8. Triglyceride is stored in adipose tissue, converted into other molecules, or used as energy 9. Lipoproteins include chylomicrons, VLDL, LDL, and HDL 10. LDL transport cholesterol to cells, and HDL transport it from cells to the liver 11. LDL are taken into cells by receptor-mediated endocytosis which is controlled by a negative-feedback mechanism Lipid Transport Transport of LDL into Cells 1. Cells have pits on the surface, which contain LDL receptors 2. LDL binds to the LDL receptors in pits 3. The LDL, bound to LDL receptors, is taken into the cell by endocytosis PROTEINS 1. Pepsin in the stomach breaks protein into smaller polypdtide chains 2. Proteolytic enzymes from the pancreas produce small peptide chains 3. Peptidases, bound to the microvilli of the small intestine, break down peptides 4. Amino acids are absorbed by cotransport, which requires transport of sodium 5. Amino acids are transported to the liver, where the amino acids can be modified or released into the bloodstream 6. Amino acids are transported into cells under the stimulation of growth hormone and insulin 7. Amino acids are used as building blocks or for energy Amino Acid Transport WATER Water can move in either direction across the wall of the small intestine, depending on the osmotic gradients across the epithelium IONS 1. Sodium, potassium, calcium, magnesium, and phosphate are actively transported 2. Chloride ions move passively through the wall of duodenum and jejunum but actively transported from the ileum 3. Calcium ions are actively transported, but vitamin D is required for transport, and the transport is under hormonal control Fluid Volumes in the Digestive Tract Assignment 1. Describe the mechanism of absorption and the route of transport for water-soluble and lipid-soluble molecules 2. Describe the enzymatic digestion of carbohydrates, lipids, and proteins, and list the breakdown products of each. 3. Explain how fats are emulsified. Describe the role of micelles, chylomicrons, VLDLs, LDLs, HDLs in the absorption and transport of lipids in the body. 4. Explain how dipeptides and tripeptides enter intestinal epithelial cells 5. Describe the movement of water through the intestinal wall 6. When and where are various ions absorbed? EFFECT OF AGING ON THE DIGESTIVE SYSTEM The mucus layer, the connective tissue, the muscles, and the secretions all tend to decrease as a person ages. These changes make an older person more open to infection and toxic agents Assignment 1. What is the general effect of aging on digestive tract secretion? 2. What are the effect of the overall decline in the defenses of the digestive tract with advancing age?