Mycology Review

Dr. David Engman

Mycoses: Fungal Diseases
Chronic, Relapsing
Rarely Contagious
Cell-Mediated Immunity
Delayed-Type Hypersensitivity
Tissue Tropism
Differences Between Fungi and Bacteria
Size (Yeast > 5 mm, Bacteria < 2 mm)
Mode of Reproduction
Cell Structure
nucleus
mitochondrion
endoplasmic reticulum
rigid cell wall (chitin vs murein)
polysaccharides (mannan, glucan) vs LPS
Mycology Basics
Yeasts vs. Molds
Dimorphism
Treatment
microtubules
membranes (sterols)
Diagnosis
Saborauds Agar
KOH
Dimorphism
Deuteromycetes (Fungi Imperfecta)
Yeast Forms
Mold Forms
Tinea Capitis
Tinea Corporis
Tinea Cruris
Tinea Pedis
Tinea Unguium
Superficial Fungal Infections
Superficial Fungal Infections
Superficial Fungal Infections
Superficial Fungal Infections
Superficial Fungal Infections
Superficial Fungal Infections
Sporotrichosis
Chromoblastomycosis
Mycetoma
Subcutaneous Fungal Infections
Subcutaneous Fungal Infections
Subcutaneous Fungal Infections
Subcutaneous Fungal Infections
Subcutaneous Fungal Infections
Subcutaneous Fungal Infections
Subcutaneous Fungal Infections
Histoplasmosis
Blastomycosis
Coccidioidomyocosis
Paracoccidioidomycosis
All are dimorphic
Systemic Fungal Infections
Histoplasmosis
Ohio and Mississippi River Valleys
Primary Pulmonary Infection
Grow Within Pulmonary Macrophages
TB-like Lesions
Histoplasmosis
Blastomycosis
Midwest and Eastern North America
Similar to Histo, but not in Macrophage
Pneumonia: Fungus Ball
Broad-Based Budding
Blastomycosis
Blastomycosis
Coccidioidomycosis
Southwest United States
Usually Self-Limiting
Coccidioidomycosis
Coccidioidomycosis
Paracoccidioidomycosis
South American Blastomycosis
Chronic Mucocutaneous Ulcers
Women Resistant - Estrogen Inhibits
Paracoccidioidomycosis
Cryptococcosis
Aspergillosis
Zygomycosis/Mucormycosis
Candidiasis
Opportunistic Fungal Infections
Cryptococcosis
Soil Contaminated with Pigeon Droppings
Encapsulated - Not Phagocytosed
Meningitis - Death
India Ink, Latex Agglutination, Brain Biopsy
Cryptococcosis
Aspergillosis
Branching Hyphae Seen on Silver Stain
Common Nosocomial in Immunocompromised
Aspergillosis
Mucormycosis
Absidia, Rhizopus, Mucor spp.
Diabetic Acidosis
Pulmonary or Rhinocerebral Disease
GI Disease in AIDS
Culture/Diagnosis Difficult
Mucormycosis
Candidiasis
Most Common Systemic Fungal Pathogen
Oral Thrush
Esophageal, Vaginal Infection Common
Colonization/Growth on Moist Skin
Germ Tube Test
Candidiasis
Candidiasis
Candidiasis
Fungal Word Association
Asteroid bodies
Broad-based budding
Copper sclerotic bodies
Diabetic Ketoacidosis
Germ Tube Test
Granulomata
Oral Thrush
Pigeon Droppings
Rose handlers disease
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding
Copper sclerotic bodies
Diabetic Ketoacidosis
Germ Tube Test
Granulomata
Oral Thrush
Pigeon Droppings
Rose handlers disease
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies
Diabetic Ketoacidosis
Germ Tube Test
Granulomata
Oral Thrush
Pigeon Droppings
Rose handlers disease
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies Chromo
Diabetic Ketoacidosis
Germ Tube Test
Granulomata
Oral Thrush
Pigeon Droppings
Rose handlers disease
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies Chromo
Diabetic Ketoacidosis Mucor
Germ Tube Test
Granulomata
Oral Thrush
Pigeon Droppings
Rose handlers disease
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies Chromo
Diabetic Ketoacidosis Mucor
Germ Tube Test Candida
Granulomata
Oral Thrush
Pigeon Droppings
Rose handlers disease
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies Chromo
Diabetic Ketoacidosis Mucor
Germ Tube Test Candida
Granulomata Histo (also Schisto, TB)
Oral Thrush
Pigeon Droppings
Rose handlers disease
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies Chromo
Diabetic Ketoacidosis Mucor
Germ Tube Test Candida
Granulomata Histo (also Schisto, TB)
Oral Thrush Candida
Pigeon Droppings
Rose handlers disease
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies Chromo
Diabetic Ketoacidosis Mucor
Germ Tube Test Candida
Granulomata Histo (also Schisto, TB)
Oral Thrush Candida
Pigeon Droppings Crypto
Rose handlers disease
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies Chromo
Diabetic Ketoacidosis Mucor
Germ Tube Test Candida
Granulomata Histo (also Schisto, TB)
Oral Thrush Candida
Pigeon Droppings Crypto
Rose handlers disease Sporothrix
Southwest United States
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies Chromo
Diabetic Ketoacidosis Mucor
Germ Tube Test Candida
Granulomata Histo (also Schisto, TB)
Oral Thrush Candida
Pigeon Droppings Crypto
Rose handlers disease Sporothrix
Southwest United States Coccidio
Woods lamp
Fungal Word Association
Asteroid bodies Sporothrix
Broad-based budding Blasto
Copper sclerotic bodies Chromo
Diabetic Ketoacidosis Mucor
Germ Tube Test Candida
Granulomata Histo (also Schisto, TB)
Oral Thrush Candida
Pigeon Droppings Crypto
Rose handlers disease Sporothrix
Southwest United States Coccidio
Woods lamp Tinea capitis