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Flaviviridae
8hepatitis C virus
$C%5
Retroviridae
Human T-cell lymphotropic
virus (HTLV type I)
RNA viruses
RNA viruses
@N( viruses
@N( viruses
Unsta"le @N(
genome
prone to
mutations
6enerates
genetic diversity
and escape
antiviral therapy
$an "e
oncogenic
8e.g.hepatitis $
virus H$75
Figure 3.17 The Biology of Cancer ( Garland Science 2007)
@etroviral replication
@etroviral replication
Human 2mmunodeAciency 7irus H27
H27 life cycle
See ani"ation at $tt/9??---.roc$e#$i!.co"?$o"e?$o"e.c4"
H27 genome
3 structural genes
gag 8group speciAc
antigen5 encodes matri!,
capsid, nucleocapsid
proteins
pol 8polymerase5 encodes
reverse transcriptase,
integrase, protease
env 8envelope5 encodes
surface - transmem"rane
proteins
6 regulatory genes
rev 8regulatory virus
protein5
tat 8transactivator5
nef 8negative regulatory
factor5
vif, vpr, vpu, env
8envelope5 encodes surface
- transmem"rane protein
8oure o4 .32 in4ection
"ntiretroviral or anti $/%
therapy
(ll approved anti)H27 drugs attempt to "loc# viral replication
within cells "y inhi"iting either @T or H27 protease.
Nucleoside analogues mimic H27 nucleosides preventing DN(
strand completion e.g. Bidovudine 8(BT5, dd2, dd$, tavudine
Non nucleoside @T inhi"itors 8NN@T25 e.g Delavirdine and
Nevirapine
<rotease inhi"itors "loc# active, catalytic site of H27 protease
Multidrug therapy
H((@T 8highly active antiretroviral therapy5 usually consists
of triple therapy including
0 % nucleoside analogues C ' protease inhi"itor
0 ' non nucleoside @T inhi"itor C '8%5 prot. inhi"itor
Flaviviridae
8hepatitis C virus
$C%5
Retroviridae
Human T-cell lymphotropic
virus (HTLV type I)
RNA viruses
RNA viruses
hepatitis $ virus
hepatitis $ virus
$C%
$C%
(Dects ?E of glo"al population
2nfects primarily hepatocytes
>&)F&E of infected individuals go on to develop hepatocellular
carcinoma 8H$$5
(t least ; genotypes #nown
.hat causes hepatocellular
.hat causes hepatocellular
carcinoma3
carcinoma3
,pstein)Barr virus
8,B75
DNA viruses
DNA viruses
E)%( Epstein )arr %irus
E)%( Epstein )arr %irus
most potent transforming agent,
widespread in all human populations
usually carried as an asymptomatic persistent
infection (latent).
virus sometimes associated with the
pathogenesis of certain types of lymphoid and
epithelial cancers, including
Burkitts lymphoma (BL),
Hodgkin disease and
Nasopharyngeal carcinoma (NPC).
Bur#itt4s Bur#itt4s
lymphoma lymphoma
Nasopharyngeal Nasopharyngeal
carcinoma carcinoma
Hodg#in4s Hodg#in4s
lymphoma lymphoma
C0#60D o4 /atient
are
=E2 ero/oiti!e
*P8 tiue tained 4or t$e
/reence o4 =E2 late
antigen.
,B7 genome and host cell transformation
,B7 genome and host cell transformation
=E2#encoded nuclear antigen 2 (=E*02)
latent "e"'rane /rotein 1 (B@P1)
"i"ic 8,C0 rece/tor
B@P2 "i"ic t$e E cell rece/tor
in vivo
in vivo
interactions "etween ,B7 and host
interactions "etween ,B7 and host
cells
cells