UTI is the common term for conditions in which there is growth of bacteria within the urinary tract Bacteriuria is presence of bacteria in bladder urine Growth of > 100.000 colony forming units significant AETIOLOGY Escherichia coli (80-90% acute UTI) (70-80% recurrent UTI) Proteus, Staphylococcus epidermidis & aureus, Enterococcus, Pseudomonas, Klebsiella. CLASSIFICATION 1. Clinical Problem -Non complicated UTI (Non obstructive) -Compilcated UTI (Obstructive) - Abnormality urinary tract - Abnormality immunology system - Renal impairment With or without symptom - Symptomatic Frequent syndrome Acute pyelonephritis Acute prostatitis -Asymptomatic PATHOGENESIS 1. Ascenderen (95%) 2. Hematogen (3%) 3. Lymphogen LABORATORY PYURIA A. urine sedimen, leucocytes 5/HPF B. urine leucocytes (non centrifuge) 2. BACTERIA IN URINE (non centrifuge) 2 bact/10 HPF or 5 bact/HPF 3. CHEMICAL TEST a. Nitrite test b. Methylen blue reductase test URINE SAMPLE LABORATORY 1. Perineal bag steril
2. Urine mid stream
3. Catheterization
4. Suprapubic aspiration INTERPRETATION OF THE RESULT URINE CULTURE Sample Colony Culture UTI Midstream >100.000 1 80% >100.000 2 96% Catheterization >100.000 1 95% Supra pubic > 1 bact Gr - 1 99% > 1000 bact Gr+ 1 99% DIAGNOSIS - SYMPTOMS
- PYURIA
- TRUE BACTERIURIA CLINICAL PRESENTATIONS - The symptoms of children with UTI depend on the level of the infections as well as the age of child - Neonatal : anorexia, lethargy, feeding difficults, body tenderness, hypothermia - Infants : non toxic - Childhood : classical symptoms
Management of Acute Symtomatic 1. Eliminate infection 2. Establish clinical and microbiological survailence to ensure 3. Prevent further infection ANTI BACTERIAL TREATMENT Depend : culture & resistensi test
1. Bactericid & Bacteriostatic 2. No side effect 3.After treatment increase therapeutic level 4. Easy 5. No resistance COMPLICATION - Evaluate ---- Anomaly. VUR and other obstruction
ren & CRF damage If + 1. Prophylactic antibiotic a. Complicated UTI, recurrence 3 X or more in one year ( 1-2 years) B. Uncomplicated UTI recurrence 3X or more in one year (3-6 months)
Drugs : Nitrofurantoin, cotrimoxazol Radiology : PIV, MSU, USG, Cyntigrahpy, Cistography, Tomography computer, after 4-6 weeks no infections. Urology intervention