CHEE 440 1

Tablet Coating
Why coat tablets?




Types of coatings
sugar coating
film coating
press coating (compression coating)
CHEE 440 2
Sugar Coating
stages involved
sealing of tablet core


subcoating

smoothing

colouring

polishing

printing

CHEE 440 3
Film Coating
involves spraying a solution of polymer + pigments +
plasticizers onto a rotated, mixed tablet bed
forms a thin, uniform film on tablet surface

materials
polymers
solvents
plasticizers
colorants
CHEE 440 4
Film Formation
latex particles dispersed
in aqueous phase
formation of thin film with
water evaporation through film
continuous film
CHEE 440 5
Coating Process
coating pans

CHEE 440 6
Coating Process
fluid beds
CHEE 440 7
Important Processing Parameters
inlet and bed temperatures
relative humidity
atomization air pressure
liquid spray rate
droplet size
drying time
CHEE 440 8
Coating Problems
picking/chipping

roughness

sticking

film cracking/peeling

CHEE 440 9
Normal Coating
Description
Reconstitution
level
Average
weight
gain
Application examples
HPMC based
Aqueous
system
11% to 15% 2.5 %
HPMC based
Organic
solvent
system
5% 2.5%
HPMC based
Aqueous/
Organic
Solvent/
Hydro
Alcoholic
system
Aqueous 11%
Organic Solvent
5%
Hydro Alcoholic
9%
2.5%
PVA based
Aqueous
system
20% to 25% 2.5%
Amoxycilli n, Azithromycin, Atenolol,
Amlodipine, Amitriptyline, Ampicilin
Ciprofloxacin, Cephadroxil ,
Cimitidine, Calcium Tablets, Citrizine
, Chloroquine Phosphate,
Clarithromycin, Erythromycin,
Ferrous Fumarate, Famotidine,
Ferrous Sulphate, Ibuprofen,
Indapamine, Losartan Potassium,
Levamisole, Methyl-Dopa,
Metronidazole+Tinidazole,
Metronidazole, Methyl Coblamine,
Mefenamic Acid, Metoprolol Tartrate,
Norfloxacin, Nifidipine,
Norfloxacin+Tinidazole, Ofloxacin,
Paracetamol, Quinine Sulphate,
Roxythromycin, Secnidazole,
Sildenafil Citrate, Trimetazidine,
Tinidazole, Tinidazole-Doxycycline,
Tinidazole + Tetracycline, Verapamil
CHEE 440 10
Enteric-coated
coating resists dissolution or disruption in stomach
but not in intestines
used for drugs that are unstable, irritating to
stomach
CHEE 440 11
Enteric Coating
Description
Reconstitution
level
Average
weight
gain
Application ** examples
Organic Enteric
Coating system,
Cellulose Acetate
Phthalate based
5 % 8 %
Aqueous coating
system & Organic
enteric coating
system. Hydroxy
Propyl Methyl
Cellulose Phthalate
based system.
Organic: 5%
Aqueous: 10%
8 %
Methacrylic acid
copolymer type "C"
USP/NF based
system
Aqueous 20%
Hydro Alcoholic
10%
Organic System
10%
9%
Aspirin, Bisacodyl
Diclofenac Sodium
Doxylamine Succinate
Garlic Tablets, Omeprazol,
Pentaprazole,
Pentoxyfyline, Rabeprazol ,
Serrosipeptadise
CHEE 440 12
Press Coating
use of compression to form coat around a pre-
formed core



used mainly to separate chemically incompatible
materials
also dual release patterns possible